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    Stackable repeating frame with integrated cell sensing connection
    1.
    发明授权
    Stackable repeating frame with integrated cell sensing connection 失效
    具有集成单元感应连接的可堆叠重复框架

    公开(公告)号：US08460815B2

    公开(公告)日：2013-06-11

    申请号：US12789938

    申请日：2010-05-28

    申请人： Andrew P. Oury ,  Kathleen M. Campbell ,  Andres V. Mituta

    发明人： Andrew P. Oury ,  Kathleen M. Campbell ,  Andres V. Mituta

    IPC分类号： H01M10/50 ,  H01M2/24

    CPC分类号： H01M10/0413 ,  H01M2/18 ,  H01M2/24 ,  H01M2/34 ,  H01M10/0525 ,  H01M10/48 ,  H01M10/613 ,  H01M10/647 ,  H01M10/6551 ,  H01M2200/103

    摘要： A module for a battery pack includes a cooling frame and a spacer frame. At least one of the first and second surfaces of the cooling frame is adapted to transfer heat to a coolant flow. A first battery cell having first and second electrically conductive tabs abuts a cooling frame member first surface. A second end of the cooling frame member includes a connection terminal for electrically connecting to the first electrically conductive tab. A spacer frame member first surface abuts the first battery cell, and a second surface abuts a second battery cell. A first end of the spacer frame member includes a connection terminal for electrically connecting to the second electrically conductive tab of the first battery cell and the first electrically conductive tab of the second battery cell.

    摘要翻译： 电池组的模块包括冷却框架和间隔框架。 冷却框架的第一和第二表面中的至少一个适于将热量传递到冷却剂流。 具有第一和第二导电突片的第一电池单元抵靠冷却框架构件第一表面。 冷却框架构件的第二端包括用于电连接到第一导电突片的连接端子。 间隔框架构件第一表面邻接第一电池单元，第二表面邻接第二电池单元。 间隔框架构件的第一端包括用于电连接到第一电池单元的第二导电凸片和第二电池单元的第一导电凸片的连接端子。

    STACKABLE REPEATING FRAME WITH INTEGRATED CELL SENSING CONNECTION
    2.
    发明申请
    STACKABLE REPEATING FRAME WITH INTEGRATED CELL SENSING CONNECTION 失效
    具有集成细胞感测连接的可堆叠重复框架

    公开(公告)号：US20110293983A1

    公开(公告)日：2011-12-01

    申请号：US12789938

    申请日：2010-05-28

    申请人： Andrew P. Oury ,  Kathleen M. Campbell ,  Andres V. Mituta

    发明人： Andrew P. Oury ,  Kathleen M. Campbell ,  Andres V. Mituta

    IPC分类号： H01M10/50

    CPC分类号： H01M10/0413 ,  H01M2/18 ,  H01M2/24 ,  H01M2/34 ,  H01M10/0525 ,  H01M10/48 ,  H01M10/613 ,  H01M10/647 ,  H01M10/6551 ,  H01M2200/103

    摘要： A module for a battery pack includes a cooling frame and a spacer frame. At least one of the first and second surfaces of the cooling frame is adapted to transfer heat to a coolant flow. A first battery cell having first and second electrically conductive tabs abuts a cooling frame member first surface. A second end of the cooling frame member includes a connection terminal for electrically connecting to the first electrically conductive tab. A spacer frame member first surface abuts the first battery cell, and a second surface abuts a second battery cell. A first end of the spacer frame member includes a connection terminal for electrically connecting to the second electrically conductive tab of the first battery cell and the first electrically conductive tab of the second battery cell.

    摘要翻译： 电池组的模块包括冷却框架和间隔框架。 冷却框架的第一和第二表面中的至少一个适于将热量传递到冷却剂流。 具有第一和第二导电突片的第一电池单元抵靠冷却框架构件第一表面。 冷却框架构件的第二端包括用于电连接到第一导电突片的连接端子。 间隔框架构件第一表面邻接第一电池单元，第二表面邻接第二电池单元。 间隔框架构件的第一端包括用于电连接到第一电池单元的第二导电凸片和第二电池单元的第一导电凸片的连接端子。

    Materials and methods for preparing protein-polymer conjugates
    5.
    发明授权
    Materials and methods for preparing protein-polymer conjugates 有权
    制备蛋白质 - 聚合物共轭物的材料和方法

    公开(公告)号：US09040664B2

    公开(公告)日：2015-05-26

    申请号：US10553570

    申请日：2004-04-08

    申请人： Kenneth Hinds ,  Danny Lewis ,  Paul Schmidt ,  Kathleen M. Campbell

    发明人： Kenneth Hinds ,  Danny Lewis ,  Paul Schmidt ,  Kathleen M. Campbell

    IPC分类号： A61K38/00 ,  C07K14/62 ,  A61K47/48 ,  A61K9/50 ,  A61K38/28

    CPC分类号： A61K47/60 ,  A61K9/5031 ,  A61K38/28 ,  C07K14/62

    摘要： The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.

    摘要翻译： 本发明涉及用于快速且有效地制备包括胰岛素 - 聚合物缀合物的蛋白质 - 聚合物缀合物的单步方法。 根据本发明的方法，蛋白质和亲水性聚合物在至少一种有机溶剂和至少一种金属螯合剂的存在下，在促进蛋白质和聚合物的缀合物形成的条件下接触。 因此，本发明涉及在残基PheB1上的聚（乙二醇）选择的蛋白质如胰岛素的位点特异性修饰。 本发明还提供了用于将缀合物包封在可生物降解的聚合物中的药物制剂。