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公开(公告)号：US20110251215A9
公开(公告)日：2011-10-13
申请号：US12692078
申请日：2010-01-22
申请人： Andrew Paul Combs , Richard B. Sparks , Eddy Wai Tsun Yue , Hao Feng , Michael Jason Bower , Wenyu Zhu
发明人： Andrew Paul Combs , Richard B. Sparks , Eddy Wai Tsun Yue , Hao Feng , Michael Jason Bower , Wenyu Zhu
IPC分类号： A61K31/4985 , A61P37/06 , A61P35/00 , C07D498/02 , C07D487/22
CPC分类号： C07D487/22 , C07D471/22
摘要： The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
摘要翻译： 本发明涉及式I的大环化合物或其药学上可接受的盐或其季铵盐，其中提供了组成成分，以及它们的组合物和使用方法，其是用于治疗JAK的JAK / ALK抑制剂 / ALK相关疾病，包括例如炎性和自身免疫性疾病，以及癌症。
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公开(公告)号：US08765727B2
公开(公告)日：2014-07-01
申请号：US12692078
申请日：2010-01-22
申请人： Andrew Paul Combs , Richard B. Sparks , Eddy Wai Tsun Yue , Hao Feng , Michael Jason Bower , Wenyu Zhu
发明人： Andrew Paul Combs , Richard B. Sparks , Eddy Wai Tsun Yue , Hao Feng , Michael Jason Bower , Wenyu Zhu
IPC分类号： A61K31/33 , C07D487/00
CPC分类号： C07D487/22 , C07D471/22
摘要： The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
摘要翻译： 本发明涉及式I的大环化合物或其药学上可接受的盐或其季铵盐，其中提供了组成成分，以及它们的组合物和使用方法，其是用于治疗JAK的JAK / ALK抑制剂 / ALK相关疾病，包括例如炎性和自身免疫性疾病，以及癌症。
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公开(公告)号：US20100190804A1
公开(公告)日：2010-07-29
申请号：US12692078
申请日：2010-01-22
申请人： Andrew Paul Combs , Richard B. Sparks , Eddy Wai Tsun Yue , Hao Feng , Michael Jason Bower , Wenyu Zhu
发明人： Andrew Paul Combs , Richard B. Sparks , Eddy Wai Tsun Yue , Hao Feng , Michael Jason Bower , Wenyu Zhu
IPC分类号： A61K31/4985 , C07D498/02 , C07D487/22 , A61P35/00 , A61P37/06
CPC分类号： C07D487/22 , C07D471/22
摘要： The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
摘要翻译： 本发明涉及式I的大环化合物或其药学上可接受的盐或其季铵盐，其中提供了组成成分，以及它们的组合物和使用方法，其是用于治疗JAK的JAK / ALK抑制剂 / ALK相关疾病，包括例如炎性和自身免疫性疾病，以及癌症。
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公开(公告)号：US07141596B2
公开(公告)日：2006-11-28
申请号：US10960344
申请日：2004-10-07
申请人： Andrew P. Combs , Eddy Wai Tsun Yue , Michael J. Bower , Wenyu Zhu , Matthew L. Crawley , Richard B. Sparks , James R. Pruitt , Amy Takvorian
发明人： Andrew P. Combs , Eddy Wai Tsun Yue , Michael J. Bower , Wenyu Zhu , Matthew L. Crawley , Richard B. Sparks , James R. Pruitt , Amy Takvorian
IPC分类号： A61K41/425 , A61K31/4439 , C07D275/02 , C07D239/24 , C07D417/04
CPC分类号： C07D275/03 , C07D417/10 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07F9/6539
摘要： The present invention provides compounds that can modulate the activity of a target protein, such as a phosphatase, that selectively binds phosphorylated peptides or proteins. The present compounds can be useful in treating diseases or disorders, including, for example, diabetes and obesity, that are connected directly or indirectly to the activity of the target protein.
摘要翻译： 本发明提供可以调节选择性结合磷酸化肽或蛋白质的靶蛋白（例如磷酸酶）的活性的化合物。 本发明化合物可用于治疗与靶蛋白的活性直接或间接连接的疾病或病症，包括例如糖尿病和肥胖症。
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5.发明授权N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase 有权N-羟基脒基杂环作为吲哚胺2,3-双加氧酶的调节剂公开(公告)号：US08507541B2
公开(公告)日：2013-08-13
申请号：US13050143
申请日：2011-03-17
IPC分类号： A61K31/42 , C07D261/04 , C07D261/14 , C07D261/06
CPC分类号： C07D261/18 , C07D261/20 , C07D307/68 , C07D333/70
摘要： The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
摘要翻译： 本发明涉及作为吲哚胺2,3-双加氧酶（IDO）的调节剂的N-羟基脒基化合物及其组合物和药物方法。
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公开(公告)号：US08377976B2
公开(公告)日：2013-02-19
申请号：US13070069
申请日：2011-03-23
IPC分类号： A61K31/425 , A61K31/42
CPC分类号： C07D413/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D417/04
摘要： The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
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7.发明申请N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE 审中-公开作为吲哚胺2,3-二氧化物的调节剂的N-羟基甲酰胺公开(公告)号：US20080214546A1
公开(公告)日：2008-09-04
申请号：US11856982
申请日：2007-09-18
IPC分类号： A61K31/5377 , C07D261/12 , A61K31/42 , C12N9/99 , A61P31/12 , A61P37/00 , A61P35/00 , C12N9/04 , C07D413/04
CPC分类号： C07D261/18 , C07D261/20 , C07D307/68 , C07D333/70
摘要： The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
摘要翻译： 本发明涉及作为吲哚胺2,3-双加氧酶（IDO）的调节剂的N-羟基脒基化合物及其组合物和药物方法。
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公开(公告)号：US20110172279A1
公开(公告)日：2011-07-14
申请号：US13070069
申请日：2011-03-23
IPC分类号： A61K31/427 , C07D417/04 , C12N9/99 , A61P35/00 , A61P27/12 , A61P37/06 , A61P35/02 , C07D261/18 , A61K31/42 , C07D277/56 , A61K31/426 , C07D261/20 , A61K31/423
CPC分类号： C07D413/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D417/04
摘要： The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
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公开(公告)号：US20080125470A1
公开(公告)日：2008-05-29
申请号：US11856967
申请日：2007-09-18
IPC分类号： A61K31/426 , A61P35/00 , C07D261/06 , A61K31/41 , C07D249/04 , A61K31/42 , C07D277/20
CPC分类号： C07D413/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D417/04
摘要： The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
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10.发明申请公开(公告)号：US20080146624A1
公开(公告)日：2008-06-19
申请号：US11857006
申请日：2007-09-18
申请人： Andrew P. Combs , Eddy Wai Tsun Yue
发明人： Andrew P. Combs , Eddy Wai Tsun Yue
IPC分类号： A61K31/41 , A61K35/00 , C07D261/06 , A61K31/42 , C07D333/06 , C07D277/02 , A61K31/426 , C07D307/02 , C07D285/08 , A61K31/38 , A61K31/34
CPC分类号： C07D263/32 , C07D261/08 , C07D263/34 , C07D271/08 , C07D277/28 , C07D285/06 , C07D307/52 , C07D333/20
摘要： The present invention is directed to amidino heterocyclic compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
摘要翻译： 本发明涉及作为吲哚胺2,3-双加氧酶（IDO）的调节剂的脒基杂环化合物，以及其组合物和药物方法。
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