公开(公告)号：US20100220903A1

公开(公告)日：2010-09-02

申请号：US12394381

申请日：2009-02-27

申请人： Andrzej May ,  Siavash Yazdanfar

发明人： Andrzej May ,  Siavash Yazdanfar

IPC分类号： G06K9/40 ,  G06K9/46 ,  G06K9/00

CPC分类号： G06K9/2018 ,  G01N21/6408 ,  G01N21/6456 ,  G06K9/00134

摘要： A method of fluorescence imaging is provided. The method provides for simultaneously acquiring image data at a plurality of phases and a plurality of frequencies from a region of interest, identifying at least one desired signal and at least one background signal in the acquired image data associated with the region of interest, constructing a digital filter based upon the at least one desired signal and the at least one background signal, wherein the digital filter is configured to enhance image contrast and applying the digital filter to the acquired image data associated with the region of interest to enhance image contrast in the acquired image data. Systems and computer programs that afford functionality of the type defined by this method are also provided.

摘要翻译： 提供荧光成像的方法。 该方法提供从感兴趣区域的多个相位和多个频率同时获取图像数据，识别所获取的与感兴趣区域相关联的图像数据中的至少一个期望信号和至少一个背景信号，构建一个 数字滤波器，其基于所述至少一个期望信号和所述至少一个背景信号，其中所述数字滤波器被配置为增强图像对比度并将所述数字滤波器应用于所获取的与所述感兴趣区域相关联的图像数据，以增强所述图像对比度 获取的图像数据。 还提供了提供由该方法定义的类型的功能的系统和计算机程序。

公开(公告)号：US08254650B2

公开(公告)日：2012-08-28

申请号：US12394381

申请日：2009-02-27

申请人： Andrzej May ,  Siavash Yazdanfar

发明人： Andrzej May ,  Siavash Yazdanfar

IPC分类号： G06K9/00

CPC分类号： G06K9/2018 ,  G01N21/6408 ,  G01N21/6456 ,  G06K9/00134

摘要： A method of fluorescence imaging is provided. The method provides for simultaneously acquiring image data at a plurality of phases and a plurality of frequencies from a region of interest, identifying at least one desired signal and at least one background signal in the acquired image data associated with the region of interest, constructing a digital filter based upon the at least one desired signal and the at least one background signal, wherein the digital filter is configured to enhance image contrast and applying the digital filter to the acquired image data associated with the region of interest to enhance image contrast in the acquired image data. Systems and computer programs that afford functionality of the type defined by this method are also provided.

摘要翻译： 提供荧光成像的方法。 该方法提供从感兴趣区域的多个相位和多个频率同时获取图像数据，识别所获取的与感兴趣区域相关联的图像数据中的至少一个期望信号和至少一个背景信号，构建一个 数字滤波器，其基于所述至少一个期望信号和所述至少一个背景信号，其中所述数字滤波器被配置为增强图像对比度并将所述数字滤波器应用于所获取的与所述感兴趣区域相关联的图像数据，以增强所述图像对比度 获取的图像数据。 还提供了提供由该方法定义的类型的功能的系统和计算机程序。

公开(公告)号：US20090267703A1

公开(公告)日：2009-10-29

申请号：US12108009

申请日：2008-04-23

申请人： Andrzej May ,  Siavash Yazdanfar

发明人： Andrzej May ,  Siavash Yazdanfar

IPC分类号： H03H7/38

CPC分类号： H03H7/40

摘要： A system including a driving source that supplies an alternating current (AC) electrical signal is provided. At least one electro-optical device is coupled as an electrical load of the driving source. The system further includes an apparatus configured to provide a dynamically adaptable electrical impedance matching between the driving source and the electro-optical load over a frequency range.

摘要翻译： 提供一种包括提供交流（AC）电信号的驱动源的系统。 至少一个电光装置作为驱动源的电负载耦合。 该系统还包括被配置为在频率范围内提供驱动源和电光负载之间的动态适应性电阻抗匹配的装置。

公开(公告)号：US20120128264A1

公开(公告)日：2012-05-24

申请号：US12952359

申请日：2010-11-23

申请人： Siavash Yazdanfar ,  Floribertus Heukensfeldt Jansen ,  Stephen Lomnes ,  Xinghua Wang

发明人： Siavash Yazdanfar ,  Floribertus Heukensfeldt Jansen ,  Stephen Lomnes ,  Xinghua Wang

IPC分类号： G06K9/40 ,  G01J1/58

CPC分类号： A61B5/0059 ,  A61B5/0064

摘要： A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.

摘要翻译： 提供了一种增强荧光成像对比度的方法。 该方法包括提供用于照亮与扫描步骤相对应的一个或多个区域的图案化照明源，使用多个扫描步骤扫描对象的表面的至少一部分，获取对应于两个或更多个扫描步骤的图像帧，扣除 来自对应于两个或更多个扫描步骤的图像帧的背景荧光，以形成一个或多个经处理的图像帧，以及使用一个或多个处理后的图像帧重建图像。

公开(公告)号：US20110043916A1

公开(公告)日：2011-02-24

申请号：US12543785

申请日：2009-08-19

申请人： Xinghua Wang ,  Mark Marshall Meyers ,  Siavash Yazdanfar

发明人： Xinghua Wang ,  Mark Marshall Meyers ,  Siavash Yazdanfar

IPC分类号： G02B23/24 ,  G02B27/42

CPC分类号： G02B23/243

摘要： A wide angle hybrid refractive-diffractive endoscope objective is provided. The objective comprises a negative meniscus lens having a first surface and a second surface; a stop adjacent to the negative meniscus lens; a positive lens adjacent to the negative lens and having a first surface and a second surface; and a hybrid refractive-diffractive element adjacent to the positive lens and having a first surface and a second surface, wherein one of the first surface, or the second surface comprises a diffractive surface, wherein the objective has an effective focal length in a range from about 0.8 mm to about 1.6 mm.

摘要翻译： 提供广角混合折射衍射内窥镜目的。 该目的包括具有第一表面和第二表面的负凹凸透镜; 靠近负弯月透镜的止动件; 与透镜相邻并具有第一表面和第二表面的正透镜; 以及与所述正透镜相邻并且具有第一表面和第二表面的混合折射衍射元件，其中所述第一表面或所述第二表面中的一个包括衍射表面，其中所述物镜具有在以下范围内的有效焦距： 约0.8mm至约1.6mm。

公开(公告)号：US07824034B2

公开(公告)日：2010-11-02

申请号：US11857581

申请日：2007-09-19

申请人： Frederick Wilson Wheeler ,  Siavash Yazdanfar

发明人： Frederick Wilson Wheeler ,  Siavash Yazdanfar

IPC分类号： A61B3/14 ,  A61B3/00 ,  A61B3/10

CPC分类号： A61B3/1216 ,  A61B3/14

摘要： An iris imaging system is provided. The iris imaging system includes at least one light source configured to illuminate an iris at a spectrum of light. The iris imaging system also includes at least one image capturing device including at least one of an indium-gallium-arsenide, lead sulphide, and lead selenide based detector and configured to capture an image of the iris via light reflected from the iris at the spectrum. The device is further configured to provide a signal representing one or more features of the iris in response to the light reflected from the iris.

摘要翻译： 提供虹膜成像系统。 虹膜成像系统包括至少一个被配置为以光谱照射虹膜的光源。 虹膜成像系统还包括至少一个图像捕获装置，其包括砷化铟镓，硫化铅和基于硒化铅的检测器中的至少一种，并被配置为通过光谱从光谱反射的光线捕获虹膜的图像 。 该装置还被配置为响应于从虹膜反射的光来提供表示虹膜的一个或多个特征的信号。

公开(公告)号：US07821720B2

公开(公告)日：2010-10-26

申请号：US12125512

申请日：2008-05-22

申请人： Xinghua Wang ,  Siavash Yazdanfar

发明人： Xinghua Wang ,  Siavash Yazdanfar

IPC分类号： G02B21/02 ,  A61B1/00

CPC分类号： G02B23/243

摘要： An endoscope objective lens for collecting combined bright field (white light) and fluorescence images includes a negative lens group, a stop, and a positive lens group. The lens has a combination of large entrance pupil diameter (≧0.4 mm) for efficiently collecting weak fluorescence light, large ratio between the entrance pupil diameter and the maximum outside diameter (Dentrance/Dmax larger than 0.2), large field of view (FFOV≧120°) and favorably corrected spherical, lateral chromatic and Petzval field curvature for both visible and near infrared wavelengths.

摘要翻译： 用于收集组合亮场（白光）和荧光图像的内窥镜物镜包括负透镜组，光阑和正透镜组。 透镜具有大的入射光瞳直径（≥0.4mm）的组合，用于有效地收集弱荧光，入射光瞳直径和最大外径之间的大比（Dentrance / Dmax大于0.2），大视场（FFOV≥ 120°），并且对于可见光和近红外波长都有良好校正的球面，横向色度和Petzval场曲率。

公开(公告)号：US20100110572A1

公开(公告)日：2010-05-06

申请号：US12263673

申请日：2008-11-03

申请人： Siavash Yazdanfar ,  Vernon Thomas Jensen ,  Stephen Johnson Lomnes

发明人： Siavash Yazdanfar ,  Vernon Thomas Jensen ,  Stephen Johnson Lomnes

IPC分类号： G02B5/22

CPC分类号： G02B5/189 ,  G02B5/20 ,  G02B5/201 ,  G02B7/006 ,  G02B26/008 ,  G02B26/0875

摘要： Provided herein are devices, systems, and methods for multimodal optical imaging. The devices include a filter assembly that is capable of rotary action during real time image acquisition. The systems include such filter assemblies, which are detachable or integrated in the systems. The methods include techniques for capturing image targets using multiple light sources such as white light and fluorescent light.

公开(公告)号：US20090244521A1

公开(公告)日：2009-10-01

申请号：US12059819

申请日：2008-03-31

申请人： Siavash Yazdanfar ,  Thomas W. Karpen

发明人： Siavash Yazdanfar ,  Thomas W. Karpen

IPC分类号： G01N21/00

CPC分类号： G01N21/6456 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2021/6493

摘要： A technique is provided for multi-mode optical imaging. The technique includes directing a visible light and an excitation light towards a specimen. The excitation light is configured to induce luminescence in the specimen. The technique also includes detecting visible light scattered or reflected from the specimen and luminescent light emitted via luminescence simultaneously via a single detector.

摘要翻译： 提供了一种多模光学成像技术。 该技术包括将可见光和激发光引向样本。 激发光被配置为在样品中诱导发光。 该技术还包括通过单个检测器同时检测从样品散射或反射的可见光和通过发光发射的发光。

公开(公告)号：US20070025917A1

公开(公告)日：2007-02-01

申请号：US11189892

申请日：2005-07-26

申请人： Peifang Tian ,  Robert Filkins ,  Siavash Yazdanfar ,  Stephen Lomnes ,  Andrew Healey ,  Pavel Fomitchov

发明人： Peifang Tian ,  Robert Filkins ,  Siavash Yazdanfar ,  Stephen Lomnes ,  Andrew Healey ,  Pavel Fomitchov

IPC分类号： A61K49/00 ,  A61K38/44

CPC分类号： A61K41/0028 ,  A61K49/0013 ,  C12Y113/12007

摘要： Methods and compositions for detecting and localizing light from a subject are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the subject. Also disclosed are methods for locating a target in a subject, such as by detecting light emission from a target site.

摘要翻译： 公开了用于检测和定位来自受试者的光的方法和组合物。 还公开了用于将光发射定位到选定区域以及用于跟踪受试者内的实体的方法。 还公开了用于在对象中定位目标物的方法，例如通过检测来自目标部位的光发射。