公开(公告)号：US06740639B1

公开(公告)日：2004-05-25

申请号：US09537088

申请日：2000-03-29

申请人： Anil Kumar Dwivedi ,  Madhu Khanna ,  Wahajul Haq ,  Ram Raghubir ,  Sudhir Srivastava ,  Puvvada Sri Ramchandra Murthy ,  Onkar Prasad Asthana ,  Jagdishwar Sahay Srivastava ,  Satyawan Singh

发明人： Anil Kumar Dwivedi ,  Madhu Khanna ,  Wahajul Haq ,  Ram Raghubir ,  Sudhir Srivastava ,  Puvvada Sri Ramchandra Murthy ,  Onkar Prasad Asthana ,  Jagdishwar Sahay Srivastava ,  Satyawan Singh

IPC分类号： A61K3808

CPC分类号： B82Y5/00 ,  A61K9/2018 ,  A61K9/7023 ,  A61K38/08 ,  A61K47/6949

摘要： The invention provides novel inclusion complexes of highly potent opioid peptide of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopropylamide with cyclodextrin, pharmaceutical preparations containing these inclusion complexes of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopropylamide with cyclodextrin derivatives, the complexes being better soluble in water and having improved biopharmaceutical properties such as lesser toxicity, better analgesic action and non-addiction properties.

摘要翻译： 本发明提供L-赖氨酸-D-丙氨酰 - 甘氨酰-N-甲基苯丙氨酰 - 甘氨酰 - 异丙基酰胺与环糊精的高效阿片样物质的新型包合物，其含有L-酪氨酰-D-丙氨酰 - 甘氨酰-N - 甲基苯丙氨酰 - 甘氨酰 - 异丙基酰胺与环糊精衍生物，该配合物更好地溶于水，并具有改善的生物药物性质，例如毒性较小，更好的镇痛作用和非成瘾性质。

公开(公告)号：US20110077294A1

公开(公告)日：2011-03-31

申请号：US12376909

申请日：2007-08-02

申请人： Ram Pratap ,  Himanshu Singh ,  Alok Kumar Verma ,  Amar Bahadur Singh ,  Priti Priti Tiwari Tiwari ,  Mukesh Srivastava ,  Arvind Kumar Srivastava ,  Anil Kumar Dwivedi ,  Satyawan Singh ,  Pratima Pnahma Svivastva Srivastava ,  Shio Kumar Singh ,  Chandishwar Nath ,  Ram Raghubir

发明人： Ram Pratap ,  Himanshu Singh ,  Alok Kumar Verma ,  Amar Bahadur Singh ,  Priti Priti Tiwari Tiwari ,  Mukesh Srivastava ,  Arvind Kumar Srivastava ,  Anil Kumar Dwivedi ,  Satyawan Singh ,  Pratima Pnahma Svivastva Srivastava ,  Shio Kumar Singh ,  Chandishwar Nath ,  Ram Raghubir

IPC分类号： A61K31/352 ,  C07D311/60 ,  A61P3/10 ,  A61P3/06

CPC分类号： C07D311/30

摘要： The present invention provides an optically active compound of general formula (I) and salts thereof: wherein R′ is selected from a group consisting of t-butyl amine, n-butylamine, iso-butylamine, iso-propyl amine, 4-phenyl-piperazine-1-ylamine, 4-(2-methoxyphenyl)-piperazin-1-ylamine, and 3,4-dimethoxy phenethyl amine; wherein R1, R2 and R3 are selected from the group consisting of hydrogen, methyl or iso pentenyl; R4, R5 and R6 are selected from the group consisting of Oil, O-alkyl, O-benzyl, O-substituted phenyl or combination thereof.

摘要翻译： 本发明提供通式（I）的光学活性化合物及其盐：其中R'选自叔丁胺，正丁胺，异丁胺，异丙基胺，4-苯基 - 哌嗪-1-基胺，4-（2-甲氧基苯基） - 哌嗪-1-基胺和3,4-二甲氧基苯乙胺; 其中R1，R2和R3选自氢，甲基或异戊烯基; R4，R5和R6选自油，O-烷基，O-苄基，O-取代的苯基或其组合。

公开(公告)号：US07959954B2

公开(公告)日：2011-06-14

申请号：US11519327

申请日：2006-09-11

申请人： Vijai Lakshmi ,  Ajet Saxena ,  Rajesh Kumar ,  Raghwendra Pal ,  Satyawan Singh ,  Arvind Kumar Srivastava ,  Preeti Tiwari ,  Deepak Raina ,  Anil Kumar Rastogi ,  Mahendra Nath Srivastava ,  Ramesh Chandra ,  Anju Puri ,  Ram Raghubir ,  Poonam Gupta ,  Narender Tadigoppula ,  Brijendra Kumar Tripathi ,  Sudhir Srivastava

发明人： Vijai Lakshmi ,  Ajet Saxena ,  Rajesh Kumar ,  Raghwendra Pal ,  Satyawan Singh ,  Arvind Kumar Srivastava ,  Preeti Tiwari ,  Deepak Raina ,  Anil Kumar Rastogi ,  Mahendra Nath Srivastava ,  Ramesh Chandra ,  Anju Puri ,  Ram Raghubir ,  Poonam Gupta ,  Narender Tadigoppula ,  Brijendra Kumar Tripathi ,  Sudhir Srivastava

IPC分类号： A61K36/00 ,  A61K38/00

CPC分类号： A61K36/58 ,  C07D493/18

摘要： A bioactive fraction obtained from Xylocarpus that is useful for the treatment of diabetes and dyslipidemia. This fraction can be provided in a pharmaceutical composition that is useful as antidiabetic and antidyslipidemic agent, or can be used in a method of treating diabetes and dyslipidemia in a subject. Also, a process for the preparation of bioactive fraction from Xylocarpus. Isomeric xyloccensins and the preparation of such compounds. Also, pharmaceutical compositions comprising a therapeutically effective amount of such isomeric xyloccensins optionally along with one or more pharmaceutically acceptable carriers, additives, lubricant and diluents and the use of such pharmaceutical compositions in a method for treating dyslipidemia.

摘要翻译： 从Xylocarpus得到的可用于治疗糖尿病和血脂异常的生物活性成分。 该级分可以提供在可用作抗糖尿病和抗脂肪代谢剂的药物组合物中，或可用于治疗受试者的糖尿病和血脂异常的方法。 另外，从Xylocarpus制备生物活性成分的方法。 异构体的含氯木酚和这些化合物的制备。 此外，药物组合物包含治疗有效量的这种异构的木糖蛋白，任选地与一种或多种药学上可接受的载体，添加剂，润滑剂和稀释剂一起使用，以及这些药物组合物在治疗血脂异常的方法中的用途。

公开(公告)号：US20070178179A1

公开(公告)日：2007-08-02

申请号：US11519327

申请日：2006-09-11

申请人： Vijai Lakshmi ,  Ajet Saxena ,  Rajesh Kumar ,  Raghwendra Pal ,  Satyawan Singh ,  Arvind Srivastava ,  Preeti Tiwari ,  Deepak Raina ,  Anil Rastogi ,  Mahendra Srivastava ,  Ramesh Chandra ,  Anju Puri ,  Ram Raghubir ,  Poonam Gupta ,  Narender Tadigoppula ,  Brijendra Tripathi ,  Sudhir Srivastava

发明人： Vijai Lakshmi ,  Ajet Saxena ,  Rajesh Kumar ,  Raghwendra Pal ,  Satyawan Singh ,  Arvind Srivastava ,  Preeti Tiwari ,  Deepak Raina ,  Anil Rastogi ,  Mahendra Srivastava ,  Ramesh Chandra ,  Anju Puri ,  Ram Raghubir ,  Poonam Gupta ,  Narender Tadigoppula ,  Brijendra Tripathi ,  Sudhir Srivastava

IPC分类号： A61K36/185

CPC分类号： A61K36/58 ,  C07D493/18

摘要： A bioactive fraction obtained from Xylocarpus that is useful for the treatment of diabetes and dyslipidemia. This fraction can be provided in a pharmaceutical composition that is useful as antidiabetic and antidyslipidemic agent, or can be used in a method of treating diabetes and dyslipidemia in a subject. Also, a process for the preparation of bioactive fraction from Xylocarpus. Novel isomeric xyloccensins and the preparation of such compounds. Also, pharmaceutical compositions comprising a therapeutically effective amount of such novel isomeric xyloccensins optionally along with one or more pharmaceutically acceptable carriers, additives, lubricant and diluents and the use of such pharmaceutical compositions in a method for treating dyslipidemia.

摘要翻译： 从Xylocarpus得到的可用于治疗糖尿病和血脂异常的生物活性成分。 该级分可以提供在可用作抗糖尿病和抗脂肪代谢剂的药物组合物中，或可用于治疗受试者的糖尿病和血脂异常的方法。 另外，从Xylocarpus制备生物活性成分的方法。 新型异构体的木糖蛋白和这些化合物的制备。 此外，药物组合物包含治疗有效量的这种新型异构的木糖蛋白，任选地与一种或多种药学上可接受的载体，添加剂，润滑剂和稀释剂一起使用，以及这些药物组合物在治疗血脂异常的方法中的用途。

公开(公告)号：US20060142303A1

公开(公告)日：2006-06-29

申请号：US11018923

申请日：2004-12-22

申请人： Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Tripathi ,  Arvind Srivastava

发明人： Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Tripathi ,  Arvind Srivastava

IPC分类号： A61K31/496 ,  A61K31/426

CPC分类号： C07D295/092 ,  C07D277/34 ,  C07D317/54 ,  C07D417/12

摘要： The present invention provides novel substituted chalcone derivatives which exhibit anti-hyperglycemic and anti-dyslipedemic activity. The invention also provides a method for treating type II diabetes and associated hyperlipidemic conditions in a mammal by administering the compounds of the present invention and compositions containing these derivatives.

摘要翻译： 本发明提供了具有抗高血糖和抗血脂异常活性的新型取代查耳酮衍生物。 本发明还提供了通过施用本发明的化合物和含有这些衍生物的组合物来治疗哺乳动物II型糖尿病和相关高脂血症的方法。

公开(公告)号：US07635779B2

公开(公告)日：2009-12-22

申请号：US11052833

申请日：2005-02-09

申请人： Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Kumar Tripathi ,  Arvind Kumar Srivastava

发明人： Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Kumar Tripathi ,  Arvind Kumar Srivastava

IPC分类号： C07D311/30

CPC分类号： C07D417/12 ,  C07D311/30

摘要： The present invention provides novel substituted flavone derivatives which exhibit anti-hyperglycemic and antidyslipedemic activity. The invention also provides a method for controlling type II diabetes and associated hyperlipidemic conditions in a mammal by administering compound of the present invention and compositions containing these derivatives.

摘要翻译： 本发明提供了具有抗高血糖和抗血脂活性的新型取代黄酮衍生物。 本发明还提供了一种通过施用本发明的化合物和含有这些衍生物的组合物来控制哺乳动物II型糖尿病和相关高脂血症的方法。

公开(公告)号：US20060178373A1

公开(公告)日：2006-08-10

申请号：US11052833

申请日：2005-02-09

申请人： Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Tripathi ,  Arvind Srivastava

发明人： Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Tripathi ,  Arvind Srivastava

IPC分类号： A61K31/496 ,  A61K31/427 ,  A61K31/353 ,  C07D417/02 ,  C07D405/02

CPC分类号： C07D417/12 ,  C07D311/30

摘要： The present invention provides novel substituted flavone derivatives which exhibit anti-hyperglycemic and antidyslipedemic activity. The invention also provides a method for controlling type II diabetes and associated hyperlipidemic conditions in a mammal by administering compound of the present invention and compositions containing these derivatives.

公开(公告)号：US07807712B2

公开(公告)日：2010-10-05

申请号：US11018923

申请日：2004-12-22

申请人： Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Kumar Tripathi ,  Arvind Kumar Srivastava

发明人： Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Kumar Tripathi ,  Arvind Kumar Srivastava

IPC分类号： A61K31/36 ,  A61K31/427 ,  A61K31/085 ,  C07D317/06 ,  C07C49/105 ,  C07C49/11 ,  A61P3/10 ,  A61P9/10

CPC分类号： C07D295/092 ,  C07D277/34 ,  C07D317/54 ,  C07D417/12

摘要： The present invention provides appropriately substituted chalcones, such as, for example, represented by the structural formula as shown herein below Wherein R1, R2 and R3 are selected from the group consisting of H, OH, O-alkyl, O-phenyl and O-substituted phenyl; B represents Ar—Z—O or RO; where Z is an alkane having up to 5 carbon atoms; R is substituted propanol amino, wherein substituted amino groups are selected from the group consisting of t-butyl, n-butyl, i-butyl, i-propyl, 4-phenyl piperazine-1-yl, 4-(2-methoxyphenyl)-piperazin-1-yl and 3,4-dimethoxy phenethyl; and Ar is thiazolidine-dione methylene phenoxy. The compounds prepared have been demonstrated to exhibit significant antidiabetic effect in various animal models indicating potential for further exploitation.

摘要翻译： 本发明提供适当取代的查尔酮，例如由如下文所示的结构式表示，其中R1，R2和R3选自H，OH，O-烷基，O-苯基和O- 取代的苯基; B表示Ar-Z-O或RO; 其中Z是具有至多5个碳原子的烷烃; R是取代的丙醇氨基，其中取代的氨基选自叔丁基，正丁基，异丁基，异丙基，4-苯基哌嗪-1-基，4-（2-甲氧基苯基） - 哌嗪-1-基和3,4-二甲氧基苯乙基; Ar是噻唑烷二酮亚甲基苯氧基。 已经证明所制备的化合物在各种动物模型中表现出显着的抗糖尿病作用，表明有可能进一步开发。