公开(公告)号：US07446243B2

公开(公告)日：2008-11-04

申请号：US10647114

申请日：2003-08-25

申请人： Anil Kumar Gupta ,  Suman Preet Singh Khanuja ,  Madan Mohan Gupta ,  Ajit Kumar Shasany ,  Neeraj Jain ,  Ram Kishor Verma ,  Mahendra Pandurang Darokar ,  Guru Das Bagchi ,  Sushil Kumar

发明人： Anil Kumar Gupta ,  Suman Preet Singh Khanuja ,  Madan Mohan Gupta ,  Ajit Kumar Shasany ,  Neeraj Jain ,  Ram Kishor Verma ,  Mahendra Pandurang Darokar ,  Guru Das Bagchi ,  Sushil Kumar

IPC分类号： A01H5/00

CPC分类号： A01H6/38 ,  A01H5/02

摘要： The present invention relates to a cultivar of Phyllanthus amarus ‘CIM-Jeevan’, producing high amount of herb, phyllanthin and hypophyllanthin, wherein said cultivar is developed through γ-irradiation of superior germplasm, the said plant produces high amount of herbage yield ranging between 1.0-1.15 kg per sqm fresh total plant herb, possesses high vegetative erect growth with a height ranging between 60 to 65 cm, produces phyllanthin ranging between 0.70-0.77% in dry herb, produces hypophyllanthin ranging between 0.32-0.37% in dry herb, and shows seed germination of about 90%.

摘要翻译： 本发明涉及一种栽培品种，其中生产大量草本植物，叶绿素和叶绿素，其中所述栽培种通过优质种质的γ-照射而发育，所述植物产生大量的草本产量， 每平方米新鲜总草药1.0-1.15公斤，高度植物性直立生长，高度在60至65厘米之间，产生干草中0.1-0.77％的叶绿素，在干草中产生0.32-0.37％的叶绿素， 并显示种子发芽率约90％。

公开(公告)号：US07375260B2

公开(公告)日：2008-05-20

申请号：US11334333

申请日：2006-01-18

申请人： Suman Preet Singh Khanuja ,  Shilpi Paul ,  Ajit Kumar Shasany ,  Anil Kumar Gupta ,  Mahendra Pandurang Darokar ,  Madan Mohan Gupta ,  Ram Kishor Verma ,  Govind Ram ,  Anuraddha Kumar ,  Raj Kishori Lal ,  Ravi Prakash Bansal ,  Anil Kumar Singh ,  Rajendra Singh Bhakuni ,  Sudeep Tandon

发明人： Suman Preet Singh Khanuja ,  Shilpi Paul ,  Ajit Kumar Shasany ,  Anil Kumar Gupta ,  Mahendra Pandurang Darokar ,  Madan Mohan Gupta ,  Ram Kishor Verma ,  Govind Ram ,  Anuraddha Kumar ,  Raj Kishori Lal ,  Ravi Prakash Bansal ,  Anil Kumar Singh ,  Rajendra Singh Bhakuni ,  Sudeep Tandon

IPC分类号： A01H5/00

CPC分类号： A01H6/14 ,  A01H5/02

摘要： The present invention is related to the development of a novel, distinct high herb and artemisinin yielding genotype of Artemisia annua obtained through systematic marker assisted breeding followed by selection of uniform population in a methodical way wherein the genotype is distinct, uniform and stably maintainable by continuous rouging of off types in the population using DNA marker at early seedling stage from nursery itself and suitable for commercial cultivation.

摘要翻译： 本发明涉及通过系统标记辅助育种获得的一种新颖，不同的高草药和青蒿素产生的​​青蒿素基因型的发展，随后以有条理的方式选择均匀群体，其中基因型是不同的，均匀的并且可持续地通过连续的维持 在幼苗本身早期苗期使用DNA标记对群体中的种类进行粗糙化，适合商业种植。

公开(公告)号：US06393763B1

公开(公告)日：2002-05-28

申请号：US09538892

申请日：2000-03-30

申请人： Sushil Kumar ,  Shiv Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishor Verma ,  Dharam Chand Jain ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Suman Preet Singh Khanuja

发明人： Sushil Kumar ,  Shiv Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishor Verma ,  Dharam Chand Jain ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Suman Preet Singh Khanuja

IPC分类号： A01B7900

CPC分类号： A01H3/00

摘要： The invention provides a method for maximization of artemisinin yield of the plant Artemisia annua, said method comprising sowing seeds of Artemisia annua plant on raised bed nursery during second and third week of December and maintaining the moisture throughout; transplanting seedlings thus obtained bearing at least 5-15 leaves into the main field fertilized with fertilizer, preferably NPK @ 80,40,40 kg/ha to achieve a population density of 50,000 to 200,000 per ha followed by light irrigation in the second week of March and irrigation every fortnight thereafter; harvesting the crop four times by cutting the plant tops leaving 75-100 cm part of plant for further regeneration, the said harvests are performed in a manner that the first harvest is done in fourth week of May, second harvest in third week of July, third harvest in second week of September and fourth harvest in third week of October of each year; and at each harvesting time care is taken to care at least one green branch, and extracting artemisinin from the plant tissue immediately after each harvest.

摘要翻译： 本发明提供了一种使青蒿植物青蒿素产量最大化的方法，所述方法包括在12月的第二和第三周在秧苗上播种蒿种子，并保持水分; 将由此获得的至少5-15叶的幼苗移植到用肥料施肥的主田中，优选为80,40,40kg / ha的NPK，以实现每公顷50,000至20万的人口密度，然后在第二周进行轻度灌溉 三月份之后每两周灌溉一次; 通过切割植物顶部将作物收割四次，留下75-100cm部分的植物进行进一步再生，所述收获的进行方式是在5月的第4周进行第一次收获，在7月的第3周进行第二次收获， 9月第二周第三次收获，每年10月第三周收获第四季; 并且在每个收获时间处理至少一个绿色分支，并且在每次收获后立即从植物组织中提取青蒿素。

公开(公告)号：US07527814B2

公开(公告)日：2009-05-05

申请号：US11699764

申请日：2007-01-30

申请人： Anil Kumar Singh ,  Suman Preet Singh Khanuja ,  Sudeep Tandon ,  Alok Kalra ,  Deeptanjali Sahoo ,  Atul Prakash Kahol ,  Madan Mohan Gupta ,  Ram Kishor Verma ,  Arun Kumar Kukreja ,  Mansoor Alam ,  Guru Das Bagachi ,  Ravi Prakash Bansal ,  Mahendra Pandurang Darokar ,  Anil Kumar Gupta

发明人： Anil Kumar Singh ,  Suman Preet Singh Khanuja ,  Sudeep Tandon ,  Alok Kalra ,  Deeptanjali Sahoo ,  Atul Prakash Kahol ,  Madan Mohan Gupta ,  Ram Kishor Verma ,  Arun Kumar Kukreja ,  Mansoor Alam ,  Guru Das Bagachi ,  Ravi Prakash Bansal ,  Mahendra Pandurang Darokar ,  Anil Kumar Gupta

IPC分类号： A61K36/00

CPC分类号： A01N65/22 ,  A01N65/00 ,  B01D11/0288 ,  Y02A40/143 ,  A01N2300/00

摘要： The invention provides a simple method for isolation of calliterpenone (16α,17 dihydroxy-3-oxo phyllocladane), a phyllocladane diterpenoid with the plant growth regulating properties, from plant genus Callicarpa.

摘要翻译： 本发明提供了一种用于从植物属Callicarpa分离具有植物生长调节性质的叶绿素二烯酮（16α，17二羟基-3-氧基十二烷）的简单方法。

公开(公告)号：US07235262B2

公开(公告)日：2007-06-26

申请号：US10822790

申请日：2004-04-13

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K35/22

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

摘要翻译： 本发明涉及一种新型药物组合物，其包含有效量的来自牛尿馏分的生物活性级分作为生物利用度促进剂和选自抗癌化合物，抗生素，药物，治疗和营养药物，离子和类似分子的药学上可接受的添加剂 到生活系统。

公开(公告)号：US06896907B2

公开(公告)日：2005-05-24

申请号：US10135763

申请日：2002-05-01

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K35/22 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  A61K35/24 ,  A61K35/23

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

摘要翻译： 本发明涉及一种新型药物组合物，其包含有效量的来自牛尿馏分的生物活性级分作为生物利用度促进剂和选自抗癌化合物，抗生素，药物，治疗和营养药物，离子和类似分子的药学上可接受的添加剂 到生活系统。

公开(公告)号：US06676974B2

公开(公告)日：2004-01-13

申请号：US10105794

申请日：2002-03-26

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Madan Mohan Gupta ,  Arvind Kumar Tripathy ,  Monika Singh ,  Janak Raj Bahl ,  Raj Kishori Lal ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Madan Mohan Gupta ,  Arvind Kumar Tripathy ,  Monika Singh ,  Janak Raj Bahl ,  Raj Kishori Lal ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Sushil Kumar

IPC分类号： A01N5906

CPC分类号： A61K36/899 ,  Y02A50/473

摘要： The present invention relates a hexane bioactive fraction and obtained from the roots of an aromatic plant named Vetiveria zizanioides commonly found in India for inhibiting the growth of drug resistant bacterial infections in humans and animals; also relates to a pharmaceutical composition comprising the bioactive extract with other additives for inhibiting the growth of drug resistant bacterial infections in humans and animals and a process for the isolation of said bioactive extract

摘要翻译： 本发明涉及己烷生物活性级分，其获自在印度通常发现的名为Vetiveria zizanioides的芳香植物的根，用于抑制人和动物中耐药细菌感染的生长; 还涉及一种药物组合物，其包含生物活性提取物与用于抑制人和动物中耐药细菌感染生长的其它添加剂和分离所述生物活性提取物的方法

公开(公告)号：US06410059B1

公开(公告)日：2002-06-25

申请号：US09726307

申请日：2000-12-01

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K3522

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： A pharmaceutical composition comprising an antibiotic and cow urine distillate in an amount effective to enhance antimicrobial effect of the antibiotic is disclosed. The antibiotic can be an antifungal agent. The antibiotic can be a quinolone or a fluoroquinolone. The antifungal agent can be azoles, clotrimazole, mystatin or amphotericin.

摘要翻译： 公开了一种药物组合物，其包含抗生素和牛尿液馏出物，其量有效提高抗生素的抗微生物作用。 抗生素可以是抗真菌剂。 抗生素可以是喹诺酮或氟喹诺酮类。 抗真菌剂可以是唑类，克霉唑，丝裂霉素或两性霉素。

公开(公告)号：US06858588B2

公开(公告)日：2005-02-22

申请号：US10403814

申请日：2003-03-31

申请人： Suman Preet Singh Khanuja ,  Jai Shanker Arya ,  Ranganathan Santha Kumar Tiruppadiripuliyur ,  Dharmendra Saikia ,  Harpreet Kaur ,  Monika Singh ,  Subhash Chandra Gupta ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Santosh Kumar Srivastava ,  Madan Mohan Gupta ,  Subash Chandra Verma ,  Anirban Pal

发明人： Suman Preet Singh Khanuja ,  Jai Shanker Arya ,  Ranganathan Santha Kumar Tiruppadiripuliyur ,  Dharmendra Saikia ,  Harpreet Kaur ,  Monika Singh ,  Subhash Chandra Gupta ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Santosh Kumar Srivastava ,  Madan Mohan Gupta ,  Subash Chandra Verma ,  Anirban Pal

IPC分类号： A61K31/704 ,  A61K45/06 ,  C07H15/06 ,  A61K31/70 ,  A61K31/7028 ,  C07C255/32 ,  C07H15/00

CPC分类号： C07H15/06 ,  A61K31/704 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (−) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.

摘要翻译： 本发明涉及名为NIAZIRIDIN的式I的新型腈糖苷及其类似物及其衍生物。 本发明还涉及一种通过生物活性指导的分离来自pod the的荚果分离下述式I的新型腈糖苷的方法，其命名为NIAZIRIDIN及其衍生物和类似物。 本发明特别涉及下述命名为NIAZIRIDIN及其衍生物和类似物的式I的新型腈糖苷增强常用抗生素如利福平，四环素和氨苄青霉素对革兰氏阳性（+）和（ - ）细菌的生物活性的生物增强活性。 生物分子还通过胃肠膜增强药物，维生素和营养素的吸收，增加其生物利用度。 因此，尼日吉林可以与药物和营养物联合使用，导致药物相关毒性降低，降低成本和化疗持续时间。

公开(公告)号：US07473768B2

公开(公告)日：2009-01-06

申请号：US10813160

申请日：2004-03-31

申请人： Suman Preet Singh Khanuja ,  Shilpi Paul ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Ashutosh Kumar Shukla ,  Madan Mohan Gupta ,  Anuruddha Kumar

发明人： Suman Preet Singh Khanuja ,  Shilpi Paul ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Ashutosh Kumar Shukla ,  Madan Mohan Gupta ,  Anuruddha Kumar

IPC分类号： C07H21/04 ,  C12Q1/68

CPC分类号： C12Q1/6895 ,  A01H1/04 ,  C07H21/04 ,  C12Q2600/13 ,  C12Q2600/156

摘要： The present invention relates to a pair of primers with forward primer of SEQ ID NO. 1 having sequence of CCAAGCTTGCTGAACGCATCGG, and reverse primer of SEQ ID No. 2 having sequence of CCAAGCTTGCCACGCAGGATTATC, and a screening method for early identification of plants Artemisia annua having high content of artemisinin and thereby helping generation of plant population with further high content of artemisinin.

摘要翻译： 本发明涉及具有SEQ ID NO：1的正向引物的一对引物。 1具有CCAAGCTTGCTGAACGCATCGG的序列，以及具有CCAAGCTTGCCACGCAGGATTATC序列的SEQ ID No.2的反向引物，以及用于早期鉴定具有高含量的青蒿素的植物艾蒿的筛选方法，从而帮助产生具有更高含量的青蒿素的植物群体。