公开(公告)号：US20050026939A1

公开(公告)日：2005-02-03

申请号：US10901574

申请日：2004-07-29

申请人： Anima Ghosal ,  Wei Tong ,  Swapan Chowdhury ,  Shmuel Zbaida ,  Mark Wirth ,  Kevin Alton ,  James Patrick ,  Craig Boyle ,  Andrew Stamford

发明人： Anima Ghosal ,  Wei Tong ,  Swapan Chowdhury ,  Shmuel Zbaida ,  Mark Wirth ,  Kevin Alton ,  James Patrick ,  Craig Boyle ,  Andrew Stamford

IPC分类号： C07D473/06 ,  A61K31/522 ,  C07D473/02

CPC分类号： C07D473/06

摘要： The present invention is directed to a metabolite of a xanthine Phosphodiesterase type 5 inhibitor having the following structure derivatives, and formulations thereof, and processes for preparing the same. Further disclosed are methods of treating a physiological disorder, symptom or disease in a patient, comprising administering to the patient an effective amount of the above compound, wherein the physiological disorder, symptom or disease is a urogenital, cardiovascular, cerebrovascular or peripheral vascular disorder, angina pectoris, hypertension, restenosis post angioplasty, endarterectomy, stent introduction, cerebral stroke, a respiratory tract disorder such as an allergic condition associated with atopy, pulmonary hypertension, an ischemic heart disorder, impaired glucose tolerance, diabetes and its related complication, insulin resistance syndrome, hyperglycemia, polycystic ovarian syndrome, a glomerular disorder, renal insufficiency, nephritis, a tubular interstitial disorder, an autoimmune disorder, glaucoma, intestinal motility, cachexia or cancer.

摘要翻译： 本发明涉及具有以下结构衍生物的黄嘌呤磷酸二酯酶5型抑制剂的代谢物及其制剂及其制备方法。 进一步公开的是治疗患者的生理障碍，症状或疾病的方法，包括向患者施用有效量的上述化合物，其中所述生理障碍，症状或疾病是泌尿生殖系统，心血管，脑血管或外周血管疾病， 心绞痛，高血压，血管成形术后再狭窄，内膜切除术，支架引入，脑中风，呼吸道疾病如与过敏相关的过敏性疾病，肺动脉高压，缺血性心脏病，糖耐量异常，糖尿病及其相关并发症，胰岛素抵抗 综合征，高血糖症，多囊卵巢综合征，肾小球疾病，肾功能不全，肾炎，管状间质性疾病，自身免疫性疾病，青光眼，肠蠕动，恶病质或癌症。

公开(公告)号：US20050192648A1

公开(公告)日：2005-09-01

申请号：US11094769

申请日：2005-03-31

申请人： Matthijs Killian ,  Bas van Dijk ,  Andreas Buechner ,  Joerg Pesch ,  Marc Majoral ,  John Parker ,  James Patrick ,  Ernst Von Wallenberg

发明人： Matthijs Killian ,  Bas van Dijk ,  Andreas Buechner ,  Joerg Pesch ,  Marc Majoral ,  John Parker ,  James Patrick ,  Ernst Von Wallenberg

IPC分类号： A61F11/04 ,  A61N1/18

CPC分类号： A61N1/36036 ,  A61N1/0541 ,  H04R2225/43

摘要： An embodiment of the present invention takes masking effects into consideration when determining stimulations signals for neural stimulation. These masking effects may be modeled using user-specific models determined by taking measurements for an implant system of an implant recipient. Or, the model may correspond to a group of individuals sharing a common characteristic or the population as a whole. These models may be, for example, psycho-physical or electrophysiological models.

摘要翻译： 当确定用于神经刺激的刺激信号时，本发明的实施例考虑到掩蔽效应。 可以使用通过对植入物接收者的植入物系统进行测量而确定的用户特定模型来建模这些掩蔽效应。 或者，该模型可能对应于一组共享特征或整体人口的个体。 这些模型可能是例如心理物理或电生理模型。

公开(公告)号：US20060227986A1

公开(公告)日：2006-10-12

申请号：US10526190

申请日：2003-09-02

申请人： Brett Swanson ,  Peter Blamey ,  Hugh McDermott ,  James Patrick

发明人： Brett Swanson ,  Peter Blamey ,  Hugh McDermott ,  James Patrick

IPC分类号： H04R25/00

CPC分类号： G11C27/02 ,  A61N1/36038 ,  G11C27/024 ,  H04R25/606

摘要： A method and apparatus for detecting an envelope of an audio signal, and a method and apparatus for enhancing the pitch cue of an audio signal perceived by a cochlear implant patient where the audio signal is processed and input to an implant device of the recipient. The methods and apparatuses use techniques such as filtering, rectifying, detecting peak values, sampling, resetting, comparing and multiplying various signals to detect the envelope or enhance the pitch cue of the audio signal.

摘要翻译： 用于检测音频信号的包络的方法和装置，以及用于增强由人工耳蜗患者感知的音频信号的音调提示的方法和装置，其中音频信号被处理并输入到接收者的植入装置。 方法和装置使用诸如过滤，整流，检测峰值，采样，复位，比较和乘法各种信号以检测包络或增强音频信号的音调提示的技术。

公开(公告)号：US07114204B2

公开(公告)日：2006-10-03

申请号：US11036413

申请日：2005-01-14

申请人： James Patrick

发明人： James Patrick

IPC分类号： A61G7/14 ,  A61G1/044 ,  A47C27/08

CPC分类号： A61G7/1021 ,  A61G7/002 ,  A61G7/103 ,  A61G7/1034 ,  A61G7/1046 ,  A61G2200/32

摘要： A patient transfer apparatus including an inflatable mattress, alternatively with a rigid top board with a patient restraint system on which a patient can be placed, when patient immobilization is required. A portable cart is included with a chamber for storage of a plurality of mattresses. The cart also has a gas/air blower and power supply system for empowering the blower. The power system includes provision for drawing power from line AC/DC, and has a rechargeable battery and charger for maintaining the battery by connecting the supply to the line AC/DC. The mattress has a perforated bottom surface for exit of air to provide an air cushion, and is constructed with a white top surface and a dark bottom surface for optimum recognition of contamination, and identification of the bottom surface which must be placed downward. The cart is coated with an antimicrobial substance to minimize the risk of contaminants.

摘要翻译： 一种患者转移装置，包括可充气床垫，或者当需要患者固定时，具有带有患者约束系统的刚性顶板，患者可以放置在患者身上。 便携式推车包括有用于存储多个床垫的室。 推车还有一个气/气鼓风机和供电系统，以鼓励鼓风机。 电力系统包括用于从AC / DC线获取电力的功能，并且具有用于通过将电源连接到AC / DC线来维持电池的可充电电池和充电器。 床垫具有穿孔的底面，用于排出空气以提供气垫，并且构造有白色顶部表面和黑色底部表面，以最佳地识别污染物，以及识别必须向下放置的底部表面。 手推车涂有抗菌物质，以尽量减少污染物的风险。

公开(公告)号：US20060156468A1

公开(公告)日：2006-07-20

申请号：US11036413

申请日：2005-01-14

申请人： James Patrick

发明人： James Patrick

IPC分类号： A61G7/10 ,  A47C27/08

CPC分类号： A61G7/1021 ,  A61G7/002 ,  A61G7/103 ,  A61G7/1034 ,  A61G7/1046 ,  A61G2200/32

摘要： A patient transfer apparatus including an inflatable mattress, alternatively with a rigid top board with a patient restraint system on which a patient can be placed, when patient immobilization is required. A portable cart is included with a chamber for storage of a plurality of mattresses. The cart also has a gas/air blower and power supply system for empowering the blower. The power system includes provision for drawing power from line AC/DC, and has a rechargeable battery and charger for maintaining the battery by connecting the supply to the line AC/DC. The mattress has a perforated bottom surface for exit of air to provide an air cushion, and is constructed with a white top surface and a dark bottom surface for optimum recognition of contamination, and identification of the bottom surface which must be placed downward. The cart is coated with an antimicrobial substance to minimize the risk of contaminants.

公开(公告)号：US09026205B2

公开(公告)日：2015-05-05

申请号：US12440815

申请日：2007-05-25

申请人： Paul Carter ,  James Patrick

发明人： Paul Carter ,  James Patrick

IPC分类号： A61N1/00 ,  A61N1/36 ,  A61N1/05 ,  A61F11/00

CPC分类号： A61N1/36032 ,  A61F11/00 ,  A61N1/0541 ,  A61N1/36036

摘要： An implantable apparatus for delivering electrical stimuli to a user, the apparatus including at least a stimulator adapted to generate stimulation signals, an electrode array, said array including a plurality of electrodes for delivering said stimulation signals; and a plurality of release sites for pharmaceutical agents, said release sites being positioned at locations along said array, said release sites being controlled such that said agents can be operatively delivered at selected ones of said locations.

摘要翻译： 一种用于向用户传送电刺激的可植入装置，所述装置至少包括适于产生刺激信号的刺激器，电极阵列，所述阵列包括用于传送所述刺激信号的多个电极; 以及用于药剂的多个释放位点，所述释放位置位于所述阵列的位置处，所述释放位点被控制，使得所述试剂可在所述位置中的选定位置可操作地递送。

公开(公告)号：US20070203557A1

公开(公告)日：2007-08-30

申请号：US11711116

申请日：2007-02-27

申请人： Bruce Gantz ,  James Patrick ,  John Parker

发明人： Bruce Gantz ,  James Patrick ,  John Parker

IPC分类号： A61N1/05

CPC分类号： A61N1/0541 ,  A61F11/004 ,  A61N1/36036

摘要： An electrode array (30) which is able to be inserted to a desired depth within the cochlea to provide useful percepts for the recipient which will also preferably not cause damage to the sensitive structures of the cochlea. The electrode array (30) is insertable through an opening in the cochlea and into at least the basal region of the cochlea and comprises an elongate carrier (31) having a proximal end, a distal end, and a plurality of electrodes (32) supported by the carrier at respective spaced locations thereon in a region between the proximal end and the distal end. A stabilising collar (35) extends outwardly from the elongate carrier (31) at or adjacent a proximal end thereof and has an abutment surface adapted to abut a portion of the cochlea surface around the cochleostomy and at least substantially prevent movement of the carrier (31) following completion of insertion of the array (30) into the cochlea.

摘要翻译： 一种电极阵列（30），其能够插入到耳蜗内的期望深度以便为受体提供有用的感知，其也优选不会对耳蜗的敏感结构造成损害。 电极阵列（30）可插入穿过耳蜗中的开口并进入耳蜗的至少基部区域，并且包括细长载体（31），其具有近端，远端和多个电极（32），其被支撑 通过所述载体在所述近端和所述远端之间的区域中的相应的间隔位置处。 稳定环（35）在其近端处或邻近其处从细长载体（31）向外延伸，并且具有适于邻近耳蜗造口术周围的耳蜗表面的一部分的邻接表面，并且至少基本上防止载体（31 ）完成将阵列（30）插入耳蜗之后。

公开(公告)号：US20050004627A1

公开(公告)日：2005-01-06

申请号：US10493675

申请日：2002-10-25

申请人： Peter Gibson ,  Thomas Lenarz ,  Minoo Lenarz ,  Miro Mackiewicz ,  John Parker ,  James Patrick

发明人： Peter Gibson ,  Thomas Lenarz ,  Minoo Lenarz ,  Miro Mackiewicz ,  John Parker ,  James Patrick

IPC分类号： A61F11/04 ,  A61N1/05

CPC分类号： A61N1/0529 ,  A61F11/04 ,  A61N1/0541 ,  A61N1/36036

摘要： An electrode array (10) that is implantable within the inferior colliculus of the midbrain and/or other appropriate regions of the brain of an implantee and adapted to provide electrical stimulation thereto. The electrode array (10) an elongate member (11) having a plurality of electrodes (12) mounted thereon in a longitudinal array. A delivery cannula (30) for delivering the electrode array (10) comprised of two half-pipes (31) is also described.

摘要翻译： 电极阵列（10），其可植入在植入物的脑的中脑和/或其它适当区域的下丘丘内，并适于对其施加电刺激。 电极阵列（10）具有以纵向阵列安装在其上的多个电极（12）的细长构件（11）。 还描述了用于输送由两个半管（31）组成的电极阵列（10）的输送插管（30）。

公开(公告)号：US20100256697A1

公开(公告)日：2010-10-07

申请号：US12440815

申请日：2007-05-25

申请人： Paul Carter ,  James Patrick

发明人： Paul Carter ,  James Patrick

IPC分类号： A61N1/00 ,  A61M37/00

CPC分类号： A61N1/36032 ,  A61F11/00 ,  A61N1/0541 ,  A61N1/36036

摘要： An implantable apparatus for delivering electrical stimuli to a user, the apparatus including at least a stimulator adapted to generate stimulation signals, an electrode array, said array including a plurality of electrodes for delivering said stimulation signals; and a plurality of release sites for pharmaceutical agents, said release sites being positioned at locations along said array, said release sites being controlled such that said agents can be operatively delivered at selected ones of said locations.

摘要翻译： 一种用于向用户传送电刺激的可植入装置，所述装置至少包括适于产生刺激信号的刺激器，电极阵列，所述阵列包括用于传送所述刺激信号的多个电极; 以及用于药剂的多个释放位点，所述释放位置位于所述阵列的位置处，所述释放位点被控制，使得所述试剂可在所述位置中的选定位置可操作地递送。

公开(公告)号：US20080051853A1

公开(公告)日：2008-02-28

申请号：US11857253

申请日：2007-09-18

申请人： John Parker ,  James Patrick

发明人： John Parker ,  James Patrick

IPC分类号： A61N1/18

CPC分类号： A61N1/0541 ,  A61N1/36036

摘要： A method and device are disclosed for neural stimulation with improved power consumption and/or effectiveness. The stimulus generator is arranged, for example via a look up table, to recognise proposed stimuli which will be masked by earlier or simultaneous stimuli. Such masked stimuli are either deleted, or replaced by another stimulus.

摘要翻译： 公开了用于具有改善的功率消耗和/或有效性的神经刺激的方法和装置。 刺激发生器例如经由查找表布置以识别将被较早或同时刺激掩蔽的所提出的刺激。 这种掩蔽的刺激被删除，或被另一种刺激所取代。