-
公开(公告)号：US5919458A
公开(公告)日：1999-07-06
申请号：US477081
申请日：1995-06-07
IPC分类号： A61K39/00 , A61K39/21 , A61P31/18 , C07K14/16 , C12N7/00 , C12N7/04 , C12N15/867 , C12N15/86
CPC分类号： C12N15/86 , A61K39/12 , A61K39/21 , C07K14/005 , C12N7/00 , A61K39/00 , C12N2740/16021 , C12N2740/16023 , C12N2740/16052 , C12N2740/16062 , C12N2740/16122 , C12N2740/16222 , Y10S530/826
摘要： This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described.
-
公开(公告)号：US5861282A
公开(公告)日：1999-01-19
申请号：US117981
申请日：1993-09-07
IPC分类号： A61K39/00 , A61K39/21 , A61P31/18 , C07K14/16 , C12N7/00 , C12N7/04 , C12N15/867 , C12N5/10 , C07K14/155 , C12N15/63 , C12P21/02
CPC分类号： C12N15/86 , A61K39/12 , A61K39/21 , C07K14/005 , C12N7/00 , A61K39/00 , C12N2740/16021 , C12N2740/16023 , C12N2740/16052 , C12N2740/16062 , C12N2740/16122 , C12N2740/16222 , Y10S530/826
摘要： This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described.
摘要翻译： 本发明涉及包含对基因组RNA包装至关重要的核苷酸序列改变的突变型HIV基因组的构建物和通过在哺乳动物细胞中表达这些构建体而产生的非感染性，免疫原性HIV颗粒。 还包括稳定产生非传染性，免疫原性HIV颗粒的细胞系。 进一步描述预防和治疗疫苗，诊断试剂和相关方法。
-
搜索结果
2 条记录 (耗时 0.02 秒)
