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公开(公告)号：US20140141474A1
公开(公告)日：2014-05-22
申请号：US14127365
申请日：2012-06-25
摘要： A method for the production of natural L-cysteine by fermentation in a production fermenter in which a microorganism strain is cultured in a fermentation medium, characterized in that the fraction of the compounds L-cysteine, L-cystine and thiazolidine in the fermentation medium is controlled in a targeted manner by an iron concentration of a maximum of 8 mg/l in the fermentation medium.
摘要翻译： 在发酵培养基中培养微生物菌株的生产发酵罐中通过发酵生产天然L-半胱氨酸的方法，其特征在于发酵培养基中L-半胱氨酸，L-胱氨酸和噻唑烷化合物的分数为 通过在发酵培养基中最大浓度为8mg / l的铁浓度以目标方式进行控制。
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公开(公告)号：US08802399B2
公开(公告)日：2014-08-12
申请号：US14127365
申请日：2012-06-25
摘要： A method for the production of natural L-cysteine by fermentation in a production fermenter in which a microorganism strain is cultured in a fermentation medium, characterized in that the fraction of the compounds L-cysteine, L-cystine and thiazolidine in the fermentation medium is controlled in a targeted manner by an iron concentration of a maximum of 8 mg/l in the fermentation medium.
摘要翻译： 在发酵培养基中培养微生物菌株的生产发酵罐中通过发酵生产天然L-半胱氨酸的方法，其特征在于发酵培养基中L-半胱氨酸，L-胱氨酸和噻唑烷化合物的分数为 通过在发酵培养基中最大浓度为8mg / l的铁浓度以目标方式进行控制。
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3.发明授权Method for producing L-cystine by fermentation under controlled oxygen saturation 有权在受控氧饱和度下通过发酵生产L-胱氨酸的方法公开(公告)号：US09074230B2
公开(公告)日：2015-07-07
申请号：US14116049
申请日：2012-05-04
IPC分类号： C12P13/12
CPC分类号： C12P13/12
摘要： The invention relates to a method for producing L-cystine by fermenting a microorganism strain in a fermentation medium, in which method L-cystine is precipitated in an amount of at least 70% relative to the total cysteine, characterized in that the O2 saturation of the fermentation medium is kept at least at 1% and at most at 40±3% during the formation of L-cystine.
摘要翻译： 本发明涉及通过在发酵培养基中发酵微生物菌株来生产L-胱氨酸的方法，其中L-胱氨酸相对于总半胱氨酸以至少70％的量沉淀，其特征在于，O 2饱和度 发酵培养基在L-胱氨酸的形成过程中保持在至少1％，最多为40±3％。
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公开(公告)号：US20080076158A1
公开(公告)日：2008-03-27
申请号：US11859350
申请日：2007-09-21
CPC分类号： C12P21/02 , C07K14/56 , C07K16/36 , C07K16/40 , C07K2317/55 , C12N9/1074 , C12Y204/01019
摘要： The present invention relates to a process for producing a heterologous protein by means of an E. coli strain in a fermentation medium, in which an E. coli strain which has a mutation in the lpp gene or in the promoter region of the lpp gene, and contains a gene coding for a heterologous protein which is functionally linked to a signal sequence coding for a signal peptide, is fermented on an industrial scale in the fermentation medium, with the E. coli strain secreting the heterologous protein into the fermentation medium, and the protein being removed from the fermentation medium, wherein the heterologous protein comprises more than 70 amino acids.
摘要翻译： 本发明涉及在发酵培养基中通过大肠杆菌菌株生产异源蛋白的方法，其中在lpp基因中或在lpp基因的启动子区域具有突变的大肠杆菌菌株， 并且包含编码与编码信号肽的信号序列功能性相关的异源蛋白质的基因，在发酵培养基中以工业规模发酵，将分泌异源蛋白质的大肠杆菌菌株发酵到发酵培养基中，以及 所述蛋白质从所述发酵培养基中除去，其中所述异源蛋白质包含超过70个氨基酸。
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5.发明申请METHOD FOR PRODUCING L-CYSTINE BY FERMENTATION UNDER CONTROLLED OXYGEN SATURATION 有权通过控制氧气饱和下发酵生产L-儿茶素的方法公开(公告)号：US20140080186A1
公开(公告)日：2014-03-20
申请号：US14116049
申请日：2012-05-04
IPC分类号： C12P13/12
CPC分类号： C12P13/12
摘要： The invention relates to a method for producing L-cystine by fermenting a microorganism strain in a fermentation medium, in which method L-cystine is precipitated in an amount of at least 70% relative to the total cysteine, characterized in that the O2 saturation of the fermentation medium is kept at least at 1% and at most at 40±3% during the formation of L-cystine.
摘要翻译： 本发明涉及通过在发酵培养基中发酵微生物菌株来生产L-胱氨酸的方法，其中L-胱氨酸相对于总半胱氨酸以至少70％的量沉淀，其特征在于，O 2饱和度 发酵培养基在L-胱氨酸的形成过程中保持在至少1％，最多为40±3％。
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6.发明申请公开(公告)号：US20070042475A1
公开(公告)日：2007-02-22
申请号：US11504288
申请日：2006-08-15
CPC分类号： C12P7/62
摘要： A method for the production of a chiral compound of the formula (I), R1 being identical or different and being H or an organic radical, where a biotransformation composition comprising a compound of the formula (II), an oxidoreductase, a redox cofactor and a cosubstrate are reacted forming the chiral compound of the formula (I) which is subsequently isolated.
摘要翻译： 制备式（I）的手性化合物的方法相同或不同，为H或有机基团，其中包含式（II）化合物的生物转化组合物， ，氧化还原酶，氧化还原辅因子和顺碱反应，形成随后分离的式（I）的手性化合物。
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