公开(公告)号：US20100305798A1

公开(公告)日：2010-12-02

申请号：US12788819

申请日：2010-05-27

申请人： Anthony Mark Phillips ,  Ming Lang Kuang ,  JungMe Park ,  Yi Murphey ,  Leonidas Kiliaris ,  Md Abul Masrur ,  Zhihang Chen

发明人： Anthony Mark Phillips ,  Ming Lang Kuang ,  JungMe Park ,  Yi Murphey ,  Leonidas Kiliaris ,  Md Abul Masrur ,  Zhihang Chen

IPC分类号： G06F19/00

CPC分类号： B60W50/085 ,  B60W40/09 ,  B60W2530/14 ,  B60W2550/141 ,  B60W2550/20 ,  Y02T10/56 ,  Y02T10/84

摘要： System and method for vehicle drive cycle determination and energy management is provided. Based on a number of inputs, the system can determine the type of road that the vehicle is likely to drive on as well as the level of traffic congestion that the vehicle is likely to experience. Using these determinations, setpoints for various degrees of freedom, such as engine speed and battery power, can be set to reduce energy usage in the vehicle.

摘要翻译： 提供车辆驱动循环确定和能量管理的系统和方法。 根据多个输入，系统可以确定车辆可能驾驶的道路类型以及车辆可能遇到的交通拥堵程度。 使用这些确定，可以设置各种自由度的设定点，例如发动机转速和电池功率，以减少车辆中的能源消耗。

公开(公告)号：US20120167288A1

公开(公告)日：2012-07-05

申请号：US12984576

申请日：2011-01-04

申请人： Yishuo Chen ,  Zhihang Chen

发明人： Yishuo Chen ,  Zhihang Chen

IPC分类号： A62B17/00 ,  A41D13/00 ,  A41D1/04

CPC分类号： A41D13/0058 ,  A62B17/005

摘要： A thermal vest having a front panel sized and shaped to substantially cover a front of a wearer's torso. A back panel is spaced apart from and opposes the front panel, the back panel being sized and shaped to cover a back of the wearer's torso. At least one pocket is on an interior of at least one of the panels, the pocket having an opening sized and shaped to receive a thermal pack. An insulative pad is selectably attached to the pocket, the insulative pad being selectably movable between a stowed position facially adjacent the pocket and a deployed, non-adjacent position away from the pocket. The insulative pad provides thermal insulation between the pocket and the wearer in the stowed position and is movable by the wearer to the deployed position when thermal insulation is not desired.

摘要翻译： 一种背心，其具有尺寸和形状以基本上覆盖穿戴者躯干前部的前面板。 后面板与前面板间隔开并与前面板相对，后面板的尺寸和形状设计成覆盖穿用者躯干的背部。 至少一个口袋位于至少一个面板的内部，口袋具有开口尺寸和形状以接收热包。 绝缘垫可选择地附接到口袋，绝缘垫可选择地在面向邻近口袋的收纳位置和远离口袋的展开的非相邻位置之间移动。 绝缘垫在收纳位置上在口袋和穿戴者之间提供热绝缘，并且当不希望进行绝热时，可由穿着者移动到展开位置。

公开(公告)号：US20140178300A1

公开(公告)日：2014-06-26

申请号：US14008715

申请日：2012-03-30

申请人： Martin Pomper ,  Zaver Bhujwalla ,  Zhihang Chen ,  Cong Li ,  Sridhar Nimmagadda ,  Marie-France Penet ,  Sangeeta Ray

发明人： Martin Pomper ,  Zaver Bhujwalla ,  Zhihang Chen ,  Cong Li ,  Sridhar Nimmagadda ,  Marie-France Penet ,  Sangeeta Ray

IPC分类号： A61K51/08 ,  A61K31/513 ,  A61K31/713 ,  A61K38/50

CPC分类号： A61K51/083 ,  A61K9/0019 ,  A61K31/513 ,  A61K31/713 ,  A61K38/50 ,  A61K47/556 ,  A61K47/59 ,  A61K47/60 ,  A61K47/64 ,  A61K47/645 ,  A61K47/65 ,  A61K47/6929 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/126 ,  A61K51/065 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/30 ,  C12N2320/32

摘要： The present invention provides targeted nanoplex molecules which carry multimodality imaging reporters together with target enzyme inhibitors such as siRNAs and target prodrug enzymes, that are useful for theranostic imaging of cells and diseases, including, for example, various cancers, and including metastatic prostate cancer. The nanoplex molecules of the present invention provide a platform technology toward many cancer subtypes and alternative therapeutic targets. Downregulation of specific pathways using targeted enzyme inhibitors further provides unique opportunities to target cancer cells selectively while sparing normal tissue. The nanoplex molecule platform described herein has the ability to deliver multiple siRNA enzyme inhibitors. Methods of diagnosis and treatment of various diseases are also included. The strategy described herein can be useful to down-regulate multi-drug resistance pathways, or repair enzymes with the goal of increasing the efficacy, safety, and efficiency of chemotherapeutic or irradiation therapies.

摘要翻译： 本发明提供了靶向的纳米复合物分子，其携带多靶区成像记录物与靶酶抑制剂如siRNA和靶前体药物酶，其可用于细胞和疾病（包括例如各种癌症，包括转移性前列腺癌）的静脉成像。 本发明的纳米复合物分子为许多癌症亚型和替代治疗靶标提供了平台技术。 使用靶向酶抑制剂的特异性途径的下调进一步提供了选择性靶向癌细胞同时保留正常组织的独特机会。 本文描述的纳米复合物分子平台具有递送多种siRNA酶抑制剂的能力。 还包括各种疾病的诊断和治疗方法。 本文描述的策略可用于下调多药耐药途径或修复酶，目的是提高化学治疗或照射疗法的功效，安全性和效率。

公开(公告)号：US10029023B2

公开(公告)日：2018-07-24

申请号：US14008715

申请日：2012-03-30

申请人： Martin Pomper ,  Zaver Bhujwalla ,  Zhihang Chen ,  Cong Li ,  Sridhar Nimmagadda ,  Marie-France Penet ,  Sangeeta Ray

发明人： Martin Pomper ,  Zaver Bhujwalla ,  Zhihang Chen ,  Cong Li ,  Sridhar Nimmagadda ,  Marie-France Penet ,  Sangeeta Ray

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B8/00 ,  A61K51/08 ,  A61K47/48 ,  A61K49/00 ,  A61K49/12 ,  A61K51/06 ,  A61K9/00 ,  C12N15/113 ,  A61K31/513 ,  A61K31/713 ,  A61K38/50

摘要： The present invention provides targeted nanoplex molecules which carry multimodality imaging reporters together with target enzyme inhibitors such as siRNAs and target prodrug enzymes, that are useful for theranostic imaging of cells and diseases, including, for example, various cancers, and including metastatic prostate cancer. The nanoplex molecules of the present invention provide a platform technology toward many cancer subtypes and alternative therapeutic targets. Downregulation of specific pathways using targeted enzyme inhibitors further provides unique opportunities to target cancer cells selectively while sparing normal tissue. The nanoplex molecule platform described herein has the ability to deliver multiple siRNA enzyme inhibitors. Methods of diagnosis and treatment of various diseases are also included. The strategy described herein can be useful to down-regulate multi-drug resistance pathways, or repair enzymes with the goal of increasing the efficacy, safety, and efficiency of chemotherapeutic or irradiation therapies.