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公开(公告)号：US20110144667A1
公开(公告)日：2011-06-16
申请号：US12877919
申请日：2010-09-08
申请人： Anthony Richard Horton , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Joseph F. Ferraro
发明人： Anthony Richard Horton , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Joseph F. Ferraro
IPC分类号： A61B17/08
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2210/0076 , A61F2220/0008 , A61F2220/0075 , A61F2230/0004 , A61F2250/0018 , A61F2310/00389 , A61K31/20 , A61L31/10 , A61L31/14 , A61L31/148
摘要： A hernia patch supporting tissue in-growth conforms to a tissue wall upon surgical installation and fixation within a patient. The hernia patch can include a base and positioning straps. The base is formed of two layers that are affixed to each other around the perimeter of the patch, for example by stitching. A stabilizing washer is provided between the two layers, and the stitch is provided peripherally around the stabilizing washer, keeping the washer free-floating between the layers. The base, positioning straps, and stabilizing washer are formed of a structure that does not separate the layers of the implant or form a space in the form of a pocket, and promotes more uniform and confluent tissue incorporation or in-growth after implantation. The hernia patch may further include a hydrolysable bioabsorbable cross-linked coating of a fatty acid based material, such as an omega-3 fatty acid based material.
摘要翻译： 支撑组织生长的疝补片在外科手术安装和固定在患者体内时符合组织壁。 疝补片可以包括基部和定位带。 底座由两层相互贴合，例如通过拼接而在贴片的周边彼此固定。 在两层之间设有一个稳定的垫圈，并且在周向围绕稳定垫圈设置线圈，保持垫片在层之间自由浮动。 基部，定位带和稳定垫圈由不分离植入物层或形成袋状空间的结构形成，并且在植入后促进更均匀和汇合的组织结合或生长。 疝补片可以进一步包括基于脂肪酸的材料如ω-3脂肪酸基材料的可水解生物可吸收的交联涂层。
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公开(公告)号：US09801982B2
公开(公告)日：2017-10-31
申请号：US12075223
申请日：2008-03-10
CPC分类号： A61L31/10 , A61F2/0063 , A61F2/06 , A61F2250/0067 , A61L31/145
摘要： A barrier device is formed of a barrier component that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. The barrier component can be a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The barrier device can have anchoring locations to provide an area on the barrier device to interface with an anchoring mechanism. The anchoring locations can include openings and/or anchor elements. The barrier device can also include truss structures that provide additional strength to the barrier component. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
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公开(公告)号：US20080206305A1
公开(公告)日：2008-08-28
申请号：US12075223
申请日：2008-03-10
CPC分类号： A61L31/10 , A61F2/0063 , A61F2/06 , A61F2250/0067 , A61L31/145
摘要： A barrier device is formed of a barrier component that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. The barrier component can be a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The barrier device can have anchoring locations to provide an area on the barrier device to interface with an anchoring mechanism. The anchoring locations can include openings and/or anchor elements. The barrier device can also include truss structures that provide additional strength to the barrier component. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译： 屏障装置由能够表现出抗炎性质，非炎症性质和/或粘合限制性能的屏障组分形成，并且对损伤的组织产生调节的愈合作用。 阻隔组分可以是至少部分由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 阻挡装置可以具有锚定位置以在阻挡装置上提供与锚定机构相接合的区域。 锚固位置可以包括开口和/或锚定元件。 阻挡装置还可以包括为屏障部件提供附加强度的桁架结构。 阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。
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4.发明授权公开(公告)号：US09592324B2
公开(公告)日：2017-03-14
申请号：US11980155
申请日：2007-10-30
CPC分类号： A61L31/14 , A61F2/0063 , A61L31/08
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译： 阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。 如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 底层结构可以是手术网的形式。 阻挡装置还设置有加强部分或部分，以帮助阻挡装置紧固以用于植入目的，并且禁止或基本上减少过度拉伸和撕裂的发生。 阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。
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5.发明授权Barrier layer with underlying medical device and one or more reinforcing support structures 有权具有底层医疗装置和一个或多个加强支撑结构的阻隔层公开(公告)号：US09492596B2
公开(公告)日：2016-11-15
申请号：US11701799
申请日：2007-02-02
CPC分类号： A61L31/145 , A61F2/0063 , A61F2/82 , A61F2002/0086 , A61F2002/009 , A61L31/16 , A61L2300/41 , A61L2300/606
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with anchoring reinforcements to aid with the fastening of the barrier device for implantation purposes and reinforcing truss sections or portions that prohibit or substantially reduce the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译： 阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。 如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 底层结构可以是手术网的形式。 隔离装置还设置有锚固加强件，以帮助阻挡装置的固定用于植入目的，并且加强桁架部分或部分，其禁止或基本上减少过度拉伸和撕裂的发生。 阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。
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6.发明申请Barrier layer with underlying medical device and one or more reinforcing support structures 有权具有底层医疗装置和一个或多个加强支撑结构的阻隔层公开(公告)号：US20080109017A1
公开(公告)日：2008-05-08
申请号：US11701799
申请日：2007-02-02
IPC分类号： A61F2/02
CPC分类号： A61L31/145 , A61F2/0063 , A61F2/82 , A61F2002/0086 , A61F2002/009 , A61L31/16 , A61L2300/41 , A61L2300/606
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with anchoring reinforcements to aid with the fastening of the barrier device for implantation purposes and reinforcing truss sections or portions that prohibit or substantially reduce the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译： 阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。 如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 底层结构可以是手术网的形式。 隔离装置还设置有锚固加强件，以帮助阻挡装置的固定用于植入目的，并且加强桁架部分或部分，其禁止或基本上减少过度拉伸和撕裂的发生。 阻挡装置可植入患者体内用于短期或长期应用，并且可包括治疗剂的受控释放。
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公开(公告)号：US08574627B2
公开(公告)日：2013-11-05
申请号：US11978840
申请日：2007-10-30
申请人： Paul Martakos , Steve A. Herweck , Jocelyn Prowse , Anthony Richard Horton , Keith M. Faucher , Joseph Ferraro
发明人： Paul Martakos , Steve A. Herweck , Jocelyn Prowse , Anthony Richard Horton , Keith M. Faucher , Joseph Ferraro
CPC分类号： A61L31/14 , A61F2/0063 , A61L31/08
摘要： A surgical mesh is formed of a biocompatible mesh structure with a coating that provides anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a implantation in a patient. The coating is generally formed of a fish oil, can include vitamin E, and may be at least partially cured. In addition, the coating can include a therapeutic agent component, such as a drug or other therapeutic agent.
摘要翻译： 外科手术网由具有涂层的生物相容性网状结构形成，所述涂层提供用于患者植入的抗炎，非炎症和抗粘附功能。 涂层通常由鱼油形成，可以包括维生素E，并且可以至少部分固化。 此外，涂层可以包括治疗剂成分，例如药物或其它治疗剂。
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公开(公告)号：US20080118550A1
公开(公告)日：2008-05-22
申请号：US11978840
申请日：2007-10-30
申请人： Paul Martakos , Steve A. Herweck , Jocelyn Prowse , Anthony Richard Horton , Keith M. Faucher , Joseph Ferraro
发明人： Paul Martakos , Steve A. Herweck , Jocelyn Prowse , Anthony Richard Horton , Keith M. Faucher , Joseph Ferraro
IPC分类号： A61K35/60
CPC分类号： A61L31/14 , A61F2/0063 , A61L31/08
摘要： A surgical mesh is formed of a biocompatible mesh structure with a coating that provides anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a implantation in a patient. The coating is generally formed of a fish oil, can include vitamin E, and may be at least partially cured. In addition, the coating can include a therapeutic agent component, such as a drug or other therapeutic agent.
摘要翻译： 外科手术网由具有涂层的生物相容性网状结构形成，所述涂层提供用于患者植入的抗炎，非炎症和抗粘附功能。 涂层通常由鱼油形成，可以包括维生素E，并且可以至少部分固化。 此外，涂层可以包括治疗剂成分，例如药物或其它治疗剂。
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