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公开(公告)号：US08530624B2
公开(公告)日：2013-09-10
申请号：US12584802
申请日：2009-09-11
IPC分类号： C07K14/00 , C07K14/435 , C07K14/46 , C07K14/47 , C07K14/475
CPC分类号： C07K14/70578
摘要： The present invention relates to novel osteoprotegerin variant proteins (GYPs) that demonstrate reduced binding affinity for their ligand TRAIL when compared to wild-type osteoprotegerin. Nucleic acids which encode these GYPs are also provided. Recombinant vectors and host cells expressing these GYPs are also encompassed as are methods of producing recombinant GYPs. The present invention also relates to compositions comprising these GYPs, and to methods of treating bone diseases characterised by increased bone turnover and/or loss. The GYPs of the invention are useful for preventing bone resorption and may be used to treat any condition resulting in abnormal bone turnover or bone loss such as osteoporosis, hypercalcemia, Paget's disease of bone, multiple myeloma, bone cancer and bone loss due to rheumatoid arthritis or osteomyelitis, and the like.
摘要翻译： 本发明涉及当与野生型骨保护素相比时，其表现出对其配体TRAIL的结合亲和力降低的新型骨保护蛋白变体蛋白（GYP）。 还提供了编码这些GYP的核酸。 重组载体和表达这些GYP的宿主细胞也包括在生产重组GYP的方法中。 本发明还涉及包含这些GYP的组合物，以及治疗以增加的骨转换和/或损失为特征的骨疾病的方法。 本发明的GYP可用于预防骨吸收，并且可用于治疗导致异常骨周转或骨丢失的任何病症，例如骨质疏松症，高钙血症，骨的佩吉特氏病，多发性骨髓瘤，骨癌和类风湿性关节炎引起的骨丢失 或骨髓炎等。
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公开(公告)号：US20100144600A1
公开(公告)日：2010-06-10
申请号：US12584802
申请日：2009-09-11
CPC分类号： C07K14/70578
摘要： The present invention relates to novel osteoprotegerin variant proteins (OVPs) that demonstrate reduce binding affinity for their ligand TRAIL when compared to wild-type osteoprotegerin. Nucleic acids which encode these OVPs are also provided. Recombinant vectors and host cells expressing these OVPs are also encompassed as are methods of producing recombinant OVPs. The present invention also relates to compositions comprising these OVPs, and to methods of treating bone diseases characterised by increased bone turnover and/or loss. The OVPs of the invention are useful for preventing bone resorption and may be used to treat any condition resulting in abnormal bone turnover or bone loss such as osteoporosis, hypercalcemia, Paget's disease of bone, multiple myeloma, bone cancer and bone loss due to rheumatoid arthritis or osteomyelitis, and the like.
摘要翻译： 本发明涉及当与野生型骨保护素相比时，其表现出降低其配体TRAIL的结合亲和力的新型骨保护蛋白变体蛋白（OVP）。 还提供了编码这些OVP的核酸。 重组载体和表达这些OVP的宿主细胞也包括在生产重组OVP的方法中。 本发明还涉及包含这些OVP的组合物，以及治疗以增加的骨转换和/或损失为特征的骨疾病的方法。 本发明的OVP可用于预防骨吸收，并且可用于治疗导致异常骨转换或骨丢失的任何病症，例如骨质疏松症，高钙血症，骨多普勒骨髓瘤，骨癌和由类风湿性关节炎引起的骨丢失 或骨髓炎等。
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公开(公告)号：US07612169B2
公开(公告)日：2009-11-03
申请号：US11303169
申请日：2005-12-13
CPC分类号： C07K14/70578
摘要： The present invention relates to novel osteoprotegerin variant proteins (OVPs) that demonstrate reduced binding affinity for their ligand TRAIL when compared to wild-type osteoprotegerin. Nucleic acids which encode these OVPs are also provided. Recombinant vectors and host cells expressing these OVPs are also encompassed as are methods of producing recombinant OVPs. The present invention also relates to compositions comprising these OVPs, and to methods of treating bone diseases characterised by increased bone turnover and/or loss. The OVPs of the invention are useful for preventing bone resorption and may be used to treat any condition resulting in abnormal bone turnover or bone loss such as osteoporosis, hypercalcemia, Paget's disease of bone, multiple myeloma, bone cancer and bone loss due to rheumatoid arthritis or osteomyelitis, and the like.
摘要翻译： 本发明涉及当与野生型骨保护素相比时，其表现出对其配体TRAIL的结合亲和力降低的新型骨保护蛋白变体蛋白（OVPs）。 还提供了编码这些OVP的核酸。 重组载体和表达这些OVP的宿主细胞也包括在生产重组OVP的方法中。 本发明还涉及包含这些OVP的组合物，以及治疗以增加的骨转换和/或损失为特征的骨疾病的方法。 本发明的OVP可用于预防骨吸收，并且可用于治疗导致异常骨转换或骨丢失的任何病症，例如骨质疏松症，高钙血症，骨多普勒骨髓瘤，骨癌和由类风湿性关节炎引起的骨丢失 或骨髓炎等。
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公开(公告)号：US20060189528A1
公开(公告)日：2006-08-24
申请号：US11303169
申请日：2005-12-13
CPC分类号： C07K14/70578
摘要： The present invention relates to novel osteoprotegerin variant proteins (OVPs) that demonstrate reduce binding affinity for their ligand TRAIL when compared to wild-type osteoprotegerin. Nucleic acids which encode these OVPs are also provided. Recombinant vectors and host cells expressing these OVPs are also encompassed as are methods of producing recombinant OVPs. The present invention also relates to compositions comprising these OVPs, and to methods of treating bone diseases characterised by increased bone turnover and/or loss. The OVPs of the invention are useful for preventing bone resorption and may be used to treat any condition resulting in abnormal bone turnover or bone loss such as osteoporosis, hypercalcemia, Paget's disease of bone, multiple myeloma, bone cancer and bone loss due to rheumatoid arthritis or osteomyelitis, and the like.
摘要翻译： 本发明涉及当与野生型骨保护素相比时，其表现出降低其配体TRAIL的结合亲和力的新型骨保护蛋白变体蛋白（OVP）。 还提供了编码这些OVP的核酸。 重组载体和表达这些OVP的宿主细胞也包括在生产重组OVP的方法中。 本发明还涉及包含这些OVP的组合物，以及治疗以增加的骨转换和/或损失为特征的骨疾病的方法。 本发明的OVP可用于预防骨吸收，并且可用于治疗导致异常骨转换或骨丢失的任何病症，例如骨质疏松症，高钙血症，骨多普勒骨髓瘤，骨癌和由类风湿性关节炎引起的骨丢失 或骨髓炎等。
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公开(公告)号：US20070225207A1
公开(公告)日：2007-09-27
申请号：US11587239
申请日：2005-04-21
申请人： Vincent Batori , Erwin Roggen , Steffen Ernst , Stina Lyngstrand
发明人： Vincent Batori , Erwin Roggen , Steffen Ernst , Stina Lyngstrand
CPC分类号： C07K14/43531 , A61K39/00 , A61K2039/57
摘要： This invention concerns variants of a group 1 mite polypeptide, wherein the mature polypeptide of the variants comprise one or more mutations in the positions or corresponding to positions consisting of P11, I14, D15, L16, M19-P24, Q28, F37, S38, T43, A46-A49, Q53-L57, V63, A66-H69, H72, D74-R77, I80, Y82, Q84, H85, S92, I113, S114, P121, V124, K126, R128-A130, A132-S136, A139, L147, A149-H152, T157, Q160, N163, H170, A171, S178, V183, D184, R189, D193, F204, A206, N207, P217, L222 of SEQ ID NO: 1 or alternatively 11, 14, 15, 16, 19-24, 28, 37, 38, 43, 46-49, 53-57, 63, 66-69, 72, 74-77, 80, 82, 84, 85, 92, 113, 114, 121, 124, 126, 128-130, 132-136, 139, 147, 149-152, 157, 160, 163, 170, 178, 183, 189, 193, 204, 206, 207, 217, 222 of the mature Der p 1 polypeptide.
摘要翻译： 本发明涉及组1螨多肽的变体，其中变体的成熟多肽包含位置或对应于由P11，I14，D15，L16，M19-P24，Q28，F37，S38等组成的位置的一个或多个突变。 T43，A46-A49，Q53-L57，V63，A66-H69，H72，D74-R77，I80，Y82，Q84，H85，S92，I113，S114，P121，V124，K126，R128-A130，A132-S136， SEQ ID NO：1的A139，L147，A149-H152，T157，Q160，N163，H170，A171，S178，V183，D184，R189，D193，F204，A206，N207，P217，L222或者11,14,15 ，16,19-24,28,37,38,43,46-49,53-57,63,66-69,72,74-77,80,82,84,85,92,113,114,121 ，成熟Der的第124,126,128-130,132-136,139,147,149-152,157,160,163,170,178,183,189,193,204,206,207,217,222。 p 1多肽。
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