公开(公告)号：US20070071670A1

公开(公告)日：2007-03-29

申请号：US10544945

申请日：2004-02-10

申请人： Anthony Storey ,  Julie Davis ,  Sally-Ann Ricketts ,  Marivi Medizabal ,  Alan Cuthbertson ,  Joseph Arukwe ,  Kirsty Heywood ,  Ian Wilson ,  Duncan Wynn ,  Michael Schafers ,  Bodu Levkau ,  Stefan Wagner ,  Hans-Jorg Breyholz ,  Klaus Kopka

发明人： Anthony Storey ,  Julie Davis ,  Sally-Ann Ricketts ,  Marivi Medizabal ,  Alan Cuthbertson ,  Joseph Arukwe ,  Kirsty Heywood ,  Ian Wilson ,  Duncan Wynn ,  Michael Schafers ,  Bodu Levkau ,  Stefan Wagner ,  Hans-Jorg Breyholz ,  Klaus Kopka

IPC分类号： A61K51/00 ,  C07D401/02

CPC分类号： A61K51/0497

摘要： The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.

摘要翻译： 本发明涉及诊断成像领域。 具体地，本发明涉及已知涉及特定基质金属蛋白酶的疾病的诊断成像。 本发明的一个实施方案是具有适用于诊断成像的基质金属蛋白酶抑制活性的化合物。 本发明还公开了一种药物组合物，其包含适合哺乳动物给药形式的本发明的诊断显像剂。 本发明还公开了合成本发明的诊断显像剂的中间体和用于制备本发明的药物组合物的试剂盒。 本发明的药物组合物可用于诊断已知涉及特定基质金属蛋白酶的疾病。

公开(公告)号：US08231858B2

公开(公告)日：2012-07-31

申请号：US10544945

申请日：2004-02-10

申请人： Anthony Storey ,  Julie Davis ,  Sally-Ann Ricketts ,  Marivi Mendizabal ,  Alan Cuthbertson ,  Joseph Arukwe ,  Kirsty Heywood ,  Ian Wilson ,  Duncan Wynn ,  Michael Schafers ,  Bodo Levkau ,  Stefan Wagner ,  Hans-Jörg Breyholz ,  Klaus Kopka

发明人： Anthony Storey ,  Julie Davis ,  Sally-Ann Ricketts ,  Marivi Mendizabal ,  Alan Cuthbertson ,  Joseph Arukwe ,  Kirsty Heywood ,  Ian Wilson ,  Duncan Wynn ,  Michael Schafers ,  Bodo Levkau ,  Stefan Wagner ,  Hans-Jörg Breyholz ,  Klaus Kopka

IPC分类号： A61K51/00 ,  A61M36/14

CPC分类号： A61K51/0497

摘要： The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.

摘要翻译： 本发明涉及诊断成像领域。 具体地，本发明涉及已知涉及特定基质金属蛋白酶的疾病的诊断成像。 本发明的一个实施方案是具有适用于诊断成像的基质金属蛋白酶抑制活性的化合物。 本发明还公开了一种药物组合物，其包含适合哺乳动物给药形式的本发明的诊断显像剂。 本发明还公开了合成本发明的诊断显像剂的中间体和用于制备本发明的药物组合物的试剂盒。 本发明的药物组合物可用于诊断已知涉及特定基质金属蛋白酶的疾病。

公开(公告)号：US20090041664A1

公开(公告)日：2009-02-12

申请号：US11794878

申请日：2005-12-22

申请人： Klaus Kopka ,  Bodo Levkau ,  Michael Schafers

发明人： Klaus Kopka ,  Bodo Levkau ,  Michael Schafers

IPC分类号： A61K51/04 ,  C07D403/10

CPC分类号： A61K51/087 ,  A61K51/0446 ,  A61K51/08 ,  C07D401/14 ,  C07D403/12

摘要： The present invention relates to novel 5-pyrrolidinylsulfonyl isatin derivatives, non-peptidyl Caspase binding Radioligands (CbRs) and CbR-transporter conjugates derived from said isatin derivatives, diagnostic compositions comprising said compounds of the invention and their use for non-invasive diagnostic imaging.

摘要翻译： 本发明涉及新型5-吡咯烷基磺酰靛红衍生物，衍生自所述靛红衍生物的非肽肽半胱氨酸蛋白酶结合放射性配体（CbR）和CbR-转运蛋白缀合物，包含本发明化合物的诊断组合物及其用于非侵入性诊断成像的用途。