公开(公告)号：US20070138076A1

公开(公告)日：2007-06-21

申请号：US11305833

申请日：2005-12-16

申请人： Antoine Daridon ,  Jiang Huang ,  Oai Phi ,  Andy May

发明人： Antoine Daridon ,  Jiang Huang ,  Oai Phi ,  Andy May

IPC分类号： B01D15/08

CPC分类号： G01N30/6004 ,  B01D15/14 ,  B01D15/18 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6047 ,  G01N30/6095 ,  G01N30/72

摘要： Embodiments of the invention provide devices, methods and systems for performing microfluidic chromatography. Particular embodiments provide microfluidic chromatography column devices which can perform chemical separation using small sample volumes and low pressure differentials across the column. One embodiment provides a microfluidic chromatography column device comprising a first, second and third capillary tube. A chromatographic packing is disposed in the second tube with a first and second support layer disposed on opposite ends of the second tube. The support layers are disposed in a substantially flat orientation within the tube. An external coupling joins the tubes such that the tubes are fluidically sealed. The device is configured to have a fluidic resistance such that a pressure differential across the column of less than about 10 psi produces a flow rate through the device of at least about 0.5 ml/min for a liquid solution.

摘要翻译： 本发明的实施方案提供用于进行微流体色谱的装置，方法和系统。 具体实施方案提供了可以使用小样品体积和穿过该柱的低压差进行化学分离的微流体色谱柱装置。 一个实施方案提供了包含第一，第二和第三毛细管的微流体色谱柱装置。 色谱填料设置在第二管中，第一和第二支撑层设置在第二管的相对端上。 支撑层在管内以基本平坦的方向设置。 外部联接器连接管子，使得管子是流体密封的。 该装置被配置为具有流体阻力，使得小于约10psi的柱上的压力差产生液体溶液通过装置的流速为至少约0.5ml / min。