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公开(公告)号：US09334317B2
公开(公告)日：2016-05-10
申请号：US13511116
申请日：2010-11-19
申请人： Antonio Bertoletti , Sastry Konduru Seetharama , Paul Anthony Macary , Soh Ha Chan , Chien Tei Too
发明人： Antonio Bertoletti , Sastry Konduru Seetharama , Paul Anthony Macary , Soh Ha Chan , Chien Tei Too
IPC分类号： C07K16/10 , C12N15/06 , C07H21/04 , A61K39/42 , C07K16/08 , G01N33/574 , G01N33/576
CPC分类号： C07K16/082 , C07K2317/32 , C07K2317/90 , G01N33/574 , G01N33/57407 , G01N33/5761 , G01N2333/02 , G01N2800/52
摘要： There is provided at least one isolated TCR-like antibody or fragment thereof, wherein the antibody or fragment thereof is capable of specifically binding to at least one HBV derived peptide.
摘要翻译： 提供至少一种分离的TCR样抗体或其片段，其中所述抗体或其片段能够特异性结合至少一种HBV衍生肽。
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公开(公告)号：US20120308580A1
公开(公告)日：2012-12-06
申请号：US13511116
申请日：2010-11-19
申请人： Antonio Bertoletti , Sastry Konduru Seetharama , Paul Anthony Macary , Soh Ha Chan , Chien Tei Too
发明人： Antonio Bertoletti , Sastry Konduru Seetharama , Paul Anthony Macary , Soh Ha Chan , Chien Tei Too
CPC分类号： C07K16/082 , C07K2317/32 , C07K2317/90 , G01N33/574 , G01N33/57407 , G01N33/5761 , G01N2333/02 , G01N2800/52
摘要： There is provided at least one isolated TCR-like antibody or fragment thereof, wherein the antibody or fragment thereof is capable of specifically binding to at least one HBV derived peptide.
摘要翻译： 提供至少一种分离的TCR样抗体或其片段，其中所述抗体或其片段能够特异性结合至少一种HBV衍生肽。
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3.发明申请Method for Producing T Cell Receptor-Like Monoclonal Antibodies and Uses Thereof 审中-公开生产T细胞受体样单克隆抗体的方法及其用途公开(公告)号：US20120294874A1
公开(公告)日：2012-11-22
申请号：US13510690
申请日：2010-11-18
IPC分类号： C07K16/28 , C12N5/20 , C12Q1/70 , C12N15/13 , A61P35/00 , C12N1/21 , C12N5/10 , C12N1/15 , C12N1/19 , A61K39/395 , G01N33/577 , C12N15/85
CPC分类号： G01N33/56994 , C07K16/085 , C07K16/2833 , C07K2317/32 , C07K2317/732 , C07K2317/92 , C12N2710/16211 , C12N2760/16111 , G01N2333/05
摘要： Methods are provided for producing T cell receptor (TCR) like antibodies that recognize peptides displayed in the context of HLA molecules. Antibodies produced by methods provided herein have the specificity of a TCR and can be used as therapeutic, diagnostic and research reagents. Also provided are TCR-like antibodies which recognize Epstein-Barr virus (EBV) peptides displayed in the context of HLA molecules and are useful for the detection and treatment of EBV and EBV-linked diseases.
摘要翻译： 提供了用于产生T细胞受体（TCR）样抗体的方法，该抗体识别在HLA分子的上下文中显示的肽。 通过本文提供的方法产生的抗体具有TCR的特异性，可用作治疗，诊断和研究试剂。 还提供了TCR样抗体，其识别在HLA分子的上下文中显示的爱泼斯坦 - 巴尔病毒（EBV）肽，并且可用于检测和治疗EBV和EBV连锁的疾病。
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公开(公告)号：US06774254B2
公开(公告)日：2004-08-10
申请号：US10240119
申请日：2002-09-26
申请人： Pak Hing Leung , Soh Ha Chan , Yongcheng Song
发明人： Pak Hing Leung , Soh Ha Chan , Yongcheng Song
IPC分类号： C07F112
CPC分类号： C07F9/6596
摘要： Novel phosphino-gold (I) compounds, a process for their preparation, pharmaceutical compositions containing such phosphino-gold (I) compounds and their use in the treatment of cancer disease are disclosed.
摘要翻译： 公开了新型膦 - 金（I）化合物，其制备方法，含有这样的膦 - 金（I）化合物的药物组合物及其在治疗癌症疾病中的用途。
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