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公开(公告)号：US07265111B2
公开(公告)日：2007-09-04
申请号：US10608689
申请日：2003-06-27
申请人： Antony Bigot , Siegfried Stengelin , Gerhard Jaehne , Andreas Herling , Guenter Mueller , Franz Jakob Hock , Michael R Myers
发明人： Antony Bigot , Siegfried Stengelin , Gerhard Jaehne , Andreas Herling , Guenter Mueller , Franz Jakob Hock , Michael R Myers
IPC分类号： C07D473/34 , C07D471/04 , A61K31/52 , A61P3/10 , A61P3/06
摘要： The present invention relates to compounds according to the general formula (I) wherein X is selected from the group consisting of wherein n and p are independently 0, 1, 2, or 3, provided that n+p is a least 1; and unsubstituted and at least monosubstituted C1-C10-alkylene-Y, C2-C10-alkylene-Y, C3-C10-cycloalkylene-Y and C3-C10-cycloalkenylene-Y; and R1, A, B, Q, T, Y, E and W have the meanings given in the description. These compounds are useful for the manufacture of a medicament for the treatment of insulin resistance, type 2 diabetes, metabolic syndrome, lipid disorders or cardiovasular disease or for providing an anti-lipolytic effect.
摘要翻译： 本发明涉及根据通式（I）的化合物，其中X选自其中n和p独立地为0,1,2或3，条件是n + p为至少1; 和未取代的和至少单取代的C 1 -C 10 - 亚烷基-Y，C 2 -C 10 - 亚烷基-Y，C 3 -C 10 - 亚烷基-Y和C 3 -C 10 - 环亚烯基 - Y; 且R 1，A，B，Q，T，Y，E和W具有说明书中给出的含义。 这些化合物可用于制备用于治疗胰岛素抵抗，2型糖尿病，代谢综合征，脂质障碍或心血管疾病或用于提供抗脂解作用的药物。
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2.发明授权Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament 有权螺环取代的1,3-丙二醇衍生物，其制备方法及其作为药物的用途公开(公告)号：US08859494B2
公开(公告)日：2014-10-14
申请号：US13176333
申请日：2011-07-05
申请人： Stefanie Keil , Elisabeth Defossa , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
发明人： Stefanie Keil , Elisabeth Defossa , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
IPC分类号： A61K38/28 , A61P5/50 , C07C59/72 , C07D213/64 , C07D305/06 , C07D213/65
CPC分类号： C07C59/72 , C07D213/64 , C07D213/65 , C07D305/06
摘要： The invention relates to spirocyclically substituted 1,3-propane dioxide derivatives, and to the physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, A and X are each defined as specified, and the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 本发明涉及螺环取代的1,3-丙二醇衍生物及其与生理相容的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，A和X各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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3.发明授权(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments 有权（2-芳氧基乙酰氨基）苯基丙酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US08648038B2
公开(公告)日：2014-02-11
申请号：US13176503
申请日：2011-07-05
申请人： Elisabeth Defossa , Stefanie Keil , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
发明人： Elisabeth Defossa , Stefanie Keil , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
CPC分类号： C07C235/24 , C07C255/44
摘要： The invention relates to substituted (2-aryloxyacetylamino)phenylpropionic acid derivatives, and to the physiologically acceptable salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, R9 and A are each defined as specified, and the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 本发明涉及取代的（2-芳氧基乙酰基氨基）苯基丙酸衍生物及其生理上可接受的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和A各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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4.发明授权Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments 有权具有氧代基的杂环取代的甲氧基苯基衍生物，其制备方法及其作为药物的用途公开(公告)号：US08530413B2
公开(公告)日：2013-09-10
申请号：US13154946
申请日：2011-06-07
申请人： Stefanie Keil , Elisabeth Defossa , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
发明人： Stefanie Keil , Elisabeth Defossa , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
CPC分类号： C07D209/34 , C07D215/227 , C07D265/36 , C07D277/68 , C07D498/04
摘要： Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicamentsThe invention relates to heterocyclically substituted methoxyphenyl derivatives with an oxo group, and to physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R10, X, n, B1, B2, B3 and B4 are each defined as specified, and to the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 具有氧代基的杂环取代的甲氧基苯基衍生物，其制备方法及其作为药物的用途本发明涉及具有氧代基的杂环取代的甲氧基苯基衍生物及其生理上相容的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 10，X，n，B 1，B 2，B 3和B 4各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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5.发明授权(Carboxylalkylenephenyl)phenyloxamides, method for the production thereof and use of same as a medicament 有权（羧基亚烷基苯基）苯氧基酰胺，其制备方法和作为药物的用途公开(公告)号：US08518875B2
公开(公告)日：2013-08-27
申请号：US12724519
申请日：2010-03-16
申请人： Elisabeth Defossa , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Johanna Kuhlmann-Gottke , Stefan Bartoschek
发明人： Elisabeth Defossa , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Johanna Kuhlmann-Gottke , Stefan Bartoschek
IPC分类号： A61K38/00 , C07C255/00
CPC分类号： C07C237/04 , C07C235/80
摘要： The invention relates to (carboxylalkylenephenyl)phenyloxamides and their physiologically tolerated salts, and their use as a medicament.
摘要翻译： 本发明涉及（羧基亚烷基苯基）苯氧基酰胺及其生理上耐受的盐，以及它们作为药物的用途。
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6.发明申请4,5-DIPHENYL-PYRIMIDINYL-OXY OR -MERCAPTO SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS 有权4,5-二苯基 - 吡啶-2-基氧基或巯基取代的羧酸，生产和使用方法作为药物公开(公告)号：US20090149486A1
公开(公告)日：2009-06-11
申请号：US12267925
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： A61K31/505 , C07D239/34 , A61P3/10
CPC分类号： C07D239/34
摘要： This invention relates to a compound of formula I, wherein R1, R2, m, n, V, W, X and Y are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式Ⅰ化合物，其中R1，R2，m，n，V，W，X和Y如本文所定义，或其生理耐受盐，其药物组合物和降血糖用途，治疗糖尿病 ，或增加胰岛素释放。
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7.发明申请4,5-DIPHENYL-PYRIMIDINYL SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS 有权4,5-二苯基 - 嘧啶取代的羧酸，用于生产和使用其作为药物的方法公开(公告)号：US20090149477A1
公开(公告)日：2009-06-11
申请号：US12267912
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： A61K31/505 , C07D239/28 , A61P3/10
CPC分类号： C07D239/26
摘要： This invention relates to a compound of formula I, wherein R1, R2, m, n and X are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，m，n和X如本文所定义，或其生理学上耐受的盐，其药物组合物和用于降低血糖，治疗糖尿病或增加胰岛素释放的用途。
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8.发明授权4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids, method for the production and use thereof as medicaments 有权4,5-二苯基 - 嘧啶基 - 氧基或巯基取代的羧酸，其生产和使用方法作为药物公开(公告)号：US07709494B2
公开(公告)日：2010-05-04
申请号：US12267925
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： C07D239/34 , A61K31/513
CPC分类号： C07D239/34
摘要： This invention relates to a compound of formula I, wherein R1, R2, m, n, V, W, X and Y are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式Ⅰ化合物，其中R1，R2，m，n，V，W，X和Y如本文所定义，或其生理耐受盐，其药物组合物和降血糖用途，治疗糖尿病 ，或增加胰岛素释放。
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9.发明授权4,5-diphenyl-pyrimidinyl substituted carboxylic acids, method for the production and use thereof as medicaments 有权4,5-二苯基 - 嘧啶基取代的羧酸，其制备方法和用作药物公开(公告)号：US07709490B2
公开(公告)日：2010-05-04
申请号：US12267912
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： C07D239/26 , A61K31/505
CPC分类号： C07D239/26
摘要： This invention relates to a compound of formula I, wherein R1, R2, m, n and X are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，m，n和X如本文所定义，或其生理学上耐受的盐，其药物组合物和用于降低血糖，治疗糖尿病或增加胰岛素释放的用途。
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10.发明授权Use of substituted pyranone acid derivatives for the treatment of metabolic syndrome 有权使用取代的吡喃酮酸衍生物治疗代谢综合征公开(公告)号：US08748483B2
公开(公告)日：2014-06-10
申请号：US12504198
申请日：2009-07-16
申请人： Harm Brummerhop , Siegfried Stengelin , Hubert Heuer , Susanne Kilp , Andreas Herling , Thomas Klabunde , Dieter Kadereit , Matthias Urmann
发明人： Harm Brummerhop , Siegfried Stengelin , Hubert Heuer , Susanne Kilp , Andreas Herling , Thomas Klabunde , Dieter Kadereit , Matthias Urmann
IPC分类号： A01N43/16 , A61K31/35 , C09B3/00 , C07D209/80 , C09B7/00
CPC分类号： A61K31/351
摘要： The invention relates to the use of substituted pyranone acid derivatives and of their physiologically acceptable salts for producing medicaments for treating the metabolic syndrome.
摘要翻译： 本发明涉及取代的吡喃酮酸衍生物及其生理学上可接受的盐用于制备用于治疗代谢综合征的药物的用途。
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