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1.发明授权4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids, method for the production and use thereof as medicaments 有权4,5-二苯基 - 嘧啶基 - 氧基或巯基取代的羧酸，其生产和使用方法作为药物公开(公告)号：US07709494B2
公开(公告)日：2010-05-04
申请号：US12267925
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： C07D239/34 , A61K31/513
CPC分类号： C07D239/34
摘要： This invention relates to a compound of formula I, wherein R1, R2, m, n, V, W, X and Y are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式Ⅰ化合物，其中R1，R2，m，n，V，W，X和Y如本文所定义，或其生理耐受盐，其药物组合物和降血糖用途，治疗糖尿病 ，或增加胰岛素释放。
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2.发明授权4,5-diphenyl-pyrimidinyl substituted carboxylic acids, method for the production and use thereof as medicaments 有权4,5-二苯基 - 嘧啶基取代的羧酸，其制备方法和用作药物公开(公告)号：US07709490B2
公开(公告)日：2010-05-04
申请号：US12267912
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： C07D239/26 , A61K31/505
CPC分类号： C07D239/26
摘要： This invention relates to a compound of formula I, wherein R1, R2, m, n and X are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，m，n和X如本文所定义，或其生理学上耐受的盐，其药物组合物和用于降低血糖，治疗糖尿病或增加胰岛素释放的用途。
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3.发明申请4,5-DIPHENYL-PYRIMIDINYL-OXY OR -MERCAPTO SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS 有权4,5-二苯基 - 吡啶-2-基氧基或巯基取代的羧酸，生产和使用方法作为药物公开(公告)号：US20090149486A1
公开(公告)日：2009-06-11
申请号：US12267925
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： A61K31/505 , C07D239/34 , A61P3/10
CPC分类号： C07D239/34
摘要： This invention relates to a compound of formula I, wherein R1, R2, m, n, V, W, X and Y are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式Ⅰ化合物，其中R1，R2，m，n，V，W，X和Y如本文所定义，或其生理耐受盐，其药物组合物和降血糖用途，治疗糖尿病 ，或增加胰岛素释放。
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4.发明申请4,5-DIPHENYL-PYRIMIDINYL SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS 有权4,5-二苯基 - 嘧啶取代的羧酸，用于生产和使用其作为药物的方法公开(公告)号：US20090149477A1
公开(公告)日：2009-06-11
申请号：US12267912
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： A61K31/505 , C07D239/28 , A61P3/10
CPC分类号： C07D239/26
摘要： This invention relates to a compound of formula I, wherein R1, R2, m, n and X are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，m，n和X如本文所定义，或其生理学上耐受的盐，其药物组合物和用于降低血糖，治疗糖尿病或增加胰岛素释放的用途。
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5.发明授权4,5-diphenyl-pyrimidinylamino substituted carboxylic acids, method for the production and use thereof as medicaments 有权4,5-二苯基 - 嘧啶基氨基取代的羧酸，其制备方法和用作药物公开(公告)号：US07713988B2
公开(公告)日：2010-05-11
申请号：US12267918
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： C07D239/42 , A61K31/505
CPC分类号： C07D239/42
摘要： This invention relates to a compound of formula I, wherein R1, R2, R3, m, n, W, X and Y are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，R 3，m，n，W，X和Y如本文所定义，或其生理耐受盐，其药物组合物和降血糖用途，治疗糖尿病 ，或增加胰岛素释放。
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6.发明申请4,5-DIPHENYL-PYRIMIDINYLAMINO SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS 有权4,5-二苯基 - 吡啶基氨基取代的羧酸，用于生产和使用其作为药物的方法公开(公告)号：US20090149487A1
公开(公告)日：2009-06-11
申请号：US12267918
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： A61K31/505 , C07D239/42 , A61P3/10
CPC分类号： C07D239/42
摘要： This invention relates to a compound of formula I, wherein R1, R2, R3, m, n, W, X and Y are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，R 3，m，n，W，X和Y如本文所定义，或其生理耐受盐，其药物组合物和降血糖用途，治疗糖尿病 ，或增加胰岛素释放。
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7.发明授权(Carboxylalkylenephenyl)phenyloxamides, method for the production thereof and use of same as a medicament 有权（羧基亚烷基苯基）苯氧基酰胺，其制备方法和作为药物的用途公开(公告)号：US08518875B2
公开(公告)日：2013-08-27
申请号：US12724519
申请日：2010-03-16
申请人： Elisabeth Defossa , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Johanna Kuhlmann-Gottke , Stefan Bartoschek
发明人： Elisabeth Defossa , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Johanna Kuhlmann-Gottke , Stefan Bartoschek
IPC分类号： A61K38/00 , C07C255/00
CPC分类号： C07C237/04 , C07C235/80
摘要： The invention relates to (carboxylalkylenephenyl)phenyloxamides and their physiologically tolerated salts, and their use as a medicament.
摘要翻译： 本发明涉及（羧基亚烷基苯基）苯氧基酰胺及其生理上耐受的盐，以及它们作为药物的用途。
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8.发明申请PHENYLAMINO-BENZOXAZOLE SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THEIR PRODUCTION AND USE THEREOF AS MEDICAMENTS 审中-公开苯甲酰基苯并噻唑取代的羧酸，其生产方法及其作为药物的用途公开(公告)号：US20090149519A1
公开(公告)日：2009-06-11
申请号：US12267896
申请日：2008-11-10
申请人： Elisabeth Defossa , Markus Follmann , Thomas Klabunde , Viktoria Dietrich , Gerhard Hessler , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Markus Follmann , Thomas Klabunde , Viktoria Dietrich , Gerhard Hessler , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： A61K31/423 , C07D263/48 , A61P3/10
CPC分类号： A61K31/423 , A61K45/06 , C07D263/58 , C07D413/12
摘要： This invention relates to a compound of formula I, wherein R1, R2, R6, R7, R8, R9, R10, m and X are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，R 6，R 7，R 8，R 9，R 10，m和X如本文所定义，或其生理上耐受的盐，其药物组合物和用于降低血糖， 治疗糖尿病或增加胰岛素释放。
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9.发明授权(Cyclopropylphenyl)phenyloxamides, method for the production thereof, and use of same as a medicament 有权（环丙基苯基）苯氧基酰胺，其制备方法及其作为药物的用途公开(公告)号：US08148375B2
公开(公告)日：2012-04-03
申请号：US12724517
申请日：2010-03-16
申请人： Elisabeth Defossa , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Johanna Kuhlmann-Gottke , Stefan Bartoschek
发明人： Elisabeth Defossa , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Johanna Kuhlmann-Gottke , Stefan Bartoschek
IPC分类号： A61K31/53 , A61K36/328
CPC分类号： C07C233/56 , C07C233/88
摘要： The invention relates to (cyclopropylphenyl) phenyloxamides and their physiologically tolerated salts, and their use as a medicament.
摘要翻译： 本发明涉及（环丙基苯基）苯氧基酰胺及其生理上耐受的盐，以及它们作为药物的用途。
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10.发明授权Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament 有权螺环取代的1,3-丙二醇衍生物，其制备方法及其作为药物的用途公开(公告)号：US08859494B2
公开(公告)日：2014-10-14
申请号：US13176333
申请日：2011-07-05
申请人： Stefanie Keil , Elisabeth Defossa , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
发明人： Stefanie Keil , Elisabeth Defossa , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
IPC分类号： A61K38/28 , A61P5/50 , C07C59/72 , C07D213/64 , C07D305/06 , C07D213/65
CPC分类号： C07C59/72 , C07D213/64 , C07D213/65 , C07D305/06
摘要： The invention relates to spirocyclically substituted 1,3-propane dioxide derivatives, and to the physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, A and X are each defined as specified, and the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 本发明涉及螺环取代的1,3-丙二醇衍生物及其与生理相容的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，A和X各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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