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公开(公告)号:US20050101602A1
公开(公告)日:2005-05-12
申请号:US10942035
申请日:2004-09-16
申请人: Anwer Basha , William Bunnelle , Michael Dart , Megan Gallagher , Jianguo Ji , Tao Li , Jennifer Pace , Keith Ryther , Karin Tietje , Kathleen Mortell , Diana Nersesian , Michael Schrimpf
发明人: Anwer Basha , William Bunnelle , Michael Dart , Megan Gallagher , Jianguo Ji , Tao Li , Jennifer Pace , Keith Ryther , Karin Tietje , Kathleen Mortell , Diana Nersesian , Michael Schrimpf
IPC分类号: A61K31/4178 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , C07D43/14
CPC分类号: A61K31/501 , A61K31/4178 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/53
摘要: Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
摘要翻译: 式(I)化合物<?in-line-formula description =“In-line Formulas”end =“lead”?> Z-Ar 1 -Ar 2 I)<?in-line-formula description =“In-line Formulas”end =“tail”?>其中Z是二氮杂双环胺,Ar 1是5或6元芳环 和Ar 2 2选自未取代或取代的5或6元杂芳基环; 未取代或取代的双环杂芳基环; 3,4-(亚甲二氧基)苯基; 咔唑基; 四氢咔唑基; 萘基; 和苯基; 其中苯基在间位或对位被0,1,2或3个取代基取代。 该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。 还公开了包含式(I)化合物和使用这些化合物和组合物的方法的药物组合物。
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公开(公告)号:US20050065178A1
公开(公告)日:2005-03-24
申请号:US10666884
申请日:2003-09-19
申请人: Anwer Basha , William Bunnelle , Michael Dart , Megan Gallagher , Jianguo Ji , Tao Li , Jennifer Pace , Keith Ryther , Karin Tietje
发明人: Anwer Basha , William Bunnelle , Michael Dart , Megan Gallagher , Jianguo Ji , Tao Li , Jennifer Pace , Keith Ryther , Karin Tietje
IPC分类号: A61K31/435 , A61P25/00 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D471/02 , A61K31/4745
CPC分类号: C07D487/08 , C07D471/04 , C07D471/08 , C07D487/04
摘要: Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from an unsubstituted or substituted 5-membered heteroaryl ring; an unsubstituted or substituted 6-membered heteroaryl ring; 3,4-(methylenedioxy)phenyl; and phenyl substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
摘要翻译: 式(I)Z-Ar1-Ar2(Ⅰ)化合物其中Z是二氮杂双环胺,Ar1是5-或6-元芳环,Ar2选自未取代或取代的5元杂芳基环; 未取代或取代的6元杂芳基环; 3,4-(亚甲二氧基)苯基; 和在间位或对位取代有0,1,2或3个取代基的苯基。 该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。 还公开了包含式(I)化合物和使用这些化合物和组合物的方法的药物组合物。
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3.
公开(公告)号:US20080097094A1
公开(公告)日:2008-04-24
申请号:US11957424
申请日:2007-12-15
申请人: Michael Schrimpf , Karin Tietje , Richard Toupence , Jianguo Ji , Anwer Basha , William Bunnelle , Jerome Daanen , Jennifer Frost , Kevin Sippy
发明人: Michael Schrimpf , Karin Tietje , Richard Toupence , Jianguo Ji , Anwer Basha , William Bunnelle , Jerome Daanen , Jennifer Frost , Kevin Sippy
IPC分类号: A61K31/55 , A61K31/4353 , A61P25/00 , C07D471/04 , C07D487/04
CPC分类号: C07D471/04 , C07D487/04
摘要: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
摘要翻译: 式I化合物,这些化合物的药物组合物,以及所述组合物用于控制哺乳动物突触传递的用途。
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4.
公开(公告)号:US20080058335A1
公开(公告)日:2008-03-06
申请号:US11755434
申请日:2007-05-30
申请人: Alan Florjancic , Michael Dart , Keith Ryther , Arturo Perez-Medrano , William Carroll , Meena Patel , Karin Tietje , Tongmei Li , Teodozyj Kolasa , Megan Gallagher , Sridhar Peddi , Jennifer Frost , Derek Nelson
发明人: Alan Florjancic , Michael Dart , Keith Ryther , Arturo Perez-Medrano , William Carroll , Meena Patel , Karin Tietje , Tongmei Li , Teodozyj Kolasa , Megan Gallagher , Sridhar Peddi , Jennifer Frost , Derek Nelson
IPC分类号: A61K31/5377 , A61K31/4245 , A61K31/426 , A61P25/00 , A61P35/00 , A61P43/00 , C07D215/00 , C07D271/04 , C07D277/62 , C07D295/00 , C07D277/02 , C07D217/00 , A61P9/00 , A61P37/00 , A61P29/00 , A61P11/00 , A61K31/47
CPC分类号: C07D277/82 , C07D277/46 , C07D277/48 , C07D277/60 , C07D417/06 , C07D417/12 , C07D477/14 , C07D513/04
摘要: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译: 本发明涉及式(I)化合物或其药物盐,前药,前药盐或其组合,其中R 1,R 2,R 2, > 3&gt;和L 1&gt;在含有这些化合物的组合物中的定义,以及使用这些化合物和组合物治疗病症和病症的方法。 本发明还涉及式(II)的化合物或药物盐,前药,前药盐或其组合,其中R 1a 1a,R 2a和(R x )n如说明书中所定义,包含这些化合物的组合物,以及使用这些化合物和组合物治疗病症和障碍的方法。
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5.
公开(公告)号:US20080064699A1
公开(公告)日:2008-03-13
申请号:US11755884
申请日:2007-05-31
申请人: Alan Florjancic , Michael Dart , Keith Ryther , Arturo Perez-Medrano , William Carroll , Meena Patel , Karin Tietje , Tongmei Li , Teodozyj Kolasa , Megan Gallagher , Sridhar Peddi , Jennifer Frost , Derek Nelson
发明人: Alan Florjancic , Michael Dart , Keith Ryther , Arturo Perez-Medrano , William Carroll , Meena Patel , Karin Tietje , Tongmei Li , Teodozyj Kolasa , Megan Gallagher , Sridhar Peddi , Jennifer Frost , Derek Nelson
IPC分类号: C07D277/38 , A61K31/426 , A61K31/428 , A61K31/4427 , C07D417/02 , C07D277/62 , A61K31/5377 , A61P25/00
CPC分类号: C07D277/46 , A61K31/429 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , C07D513/04
摘要: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,前体药物,前药盐或其组合,其中R 1,R 2,R 2, 在本说明书中定义了含有这些化合物的组合物,以及使用这些化合物治疗病症和病症的方法,其中,R 3,R 4,R 2和L 2 和组合物。
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公开(公告)号:US20070037801A1
公开(公告)日:2007-02-15
申请号:US11315862
申请日:2005-12-21
申请人: Jennifer Frost , Karin Tietje , Michael Dart , Michael Meyer
发明人: Jennifer Frost , Karin Tietje , Michael Dart , Michael Meyer
IPC分类号: A61K31/5377 , A61K31/454 , A61K31/405 , A61K31/404 , A61K31/4439 , A61K31/427 , C07D417/02 , C07D405/02 , C07D413/02 , C07D403/02
CPC分类号: C07D403/06 , C07D209/12 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要: The present invention provides novel compounds of Formula (I) which are CB2 selective ligands useful for the treatment of pain.
摘要翻译: 本发明提供了新颖的式(I)化合物,其为可用于治疗疼痛的CB 2/2选择性配体。
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公开(公告)号:US20060287290A1
公开(公告)日:2006-12-21
申请号:US11509381
申请日:2006-08-24
申请人: Michael Dart , Xenia Searle , Karin Tietje , Richard Toupence
发明人: Michael Dart , Xenia Searle , Karin Tietje , Richard Toupence
IPC分类号: C07D471/02 , A61K31/4745 , A61K31/4743 , A61K31/4741 , A61K31/426 , A61K31/433 , A61K31/42 , A61K31/4178 , A61K31/404 , A61K31/397
CPC分类号: C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D495/04
摘要: Compounds of formula (I) are novel CNS active agents that are useful for treating pain and for treating other disorders associated with the cholinergic system.
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公开(公告)号:US20110065685A1
公开(公告)日:2011-03-17
申请号:US12815163
申请日:2010-06-14
IPC分类号: A61K31/404 , C07D401/06 , C07D413/06 , C07D403/06 , C07D405/06 , C07D209/42 , C07D417/06 , A61K31/454 , A61K31/5377 , A61K31/4439 , A61K31/4178 , A61K31/427 , A61K31/55 , A61P25/00 , A61P29/00 , A61P37/00 , A61P35/00 , A61P11/00 , A61P9/00
CPC分类号: C07D403/06 , C07D209/12 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要: The present invention provides novel compounds of Formula (I) which are CB2 selective ligands useful for the treatment of pain.
摘要翻译: 本发明提供了新颖的式(I)化合物,它们是可用于治疗疼痛的CB2选择性配体。
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公开(公告)号:US07750039B2
公开(公告)日:2010-07-06
申请号:US12370727
申请日:2009-02-13
IPC分类号: A61K31/55 , A61K31/5377 , A61K31/454 , A61K31/4439 , A61K31/404
CPC分类号: C07D403/06 , C07D209/12 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要: The present invention provides novel compounds of Formula (I) which are CB2 selective ligands useful for the treatment of pain.
摘要翻译: 本发明提供了新颖的式(I)化合物,它们是可用于治疗疼痛的CB2选择性配体。
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