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公开(公告)号：US20220187181A1
公开(公告)日：2022-06-16
申请号：US17506396
申请日：2021-10-20
摘要： The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.
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2.发明申请公开(公告)号：US20170010369A1
公开(公告)日：2017-01-12
申请号：US15116173
申请日：2015-02-03
发明人： Harrison H. BARRETT , Brian MILLER , Yijun DING , Liying CHEN , John William HOPPIN , Luca CAUCCI
CPC分类号： G01T1/2942 , A61B6/037 , A61B6/4258 , A61B6/5205 , G01T1/161 , G01T1/2985 , G01T5/08
摘要： The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.
摘要翻译： 本发明提供用于体内和离体组织的3D成像的方法和系统。 所公开的系统和方法采用放射自显影方法，其中检测由组织内的放射性组合物发射的颗粒。 一旦检测到，组织内的颗粒源的3D表示被重建用于观察和分析。
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公开(公告)号：US20200049607A1
公开(公告)日：2020-02-13
申请号：US16653922
申请日：2019-10-15
摘要： The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.
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公开(公告)号：US20180052242A1
公开(公告)日：2018-02-22
申请号：US15729428
申请日：2017-10-10
发明人： Harrison H. BARRETT , Brian MILLER , Yijun DING , Liying CHEN , John William HOPPIN , Luca CAUCCI
CPC分类号： G01T1/2942 , A61B6/037 , A61B6/4258 , A61B6/5205 , G01T1/161 , G01T1/2985 , G01T5/08
摘要： The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.
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公开(公告)号：US20170343460A1
公开(公告)日：2017-11-30
申请号：US15526514
申请日：2015-11-11
CPC分类号： G01N15/0227 , A61B6/037 , A61B6/4241 , A61B6/4258 , A61B6/5205 , G01B7/004 , G01N15/02 , G01T1/2942
摘要： The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.
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6.发明公开公开(公告)号：US20230386039A1
公开(公告)日：2023-11-30
申请号：US18249940
申请日：2021-10-22
发明人： Luca CAUCCI , Harrison H. BARRETT
CPC分类号： G06T7/0016 , G16H50/50 , G06T2207/30024 , G06T2207/10064 , G06T2207/10108 , G06T2207/10056 , G06T2207/10104
摘要： Many biologic processes taking place inside a living organism are unpredictable in time and space, and cannot be known exactly. These mechanisms and interactions among them are better modeled as physiological random processes, the statistics of which are fully described by joint characteristic functionals. The present invention provides methods for the estimation of joint characteristic functionals through imaging of multiple physiological random processes. This technology can be used to study complex diseases, such as tumors and viral infections, by imaging the biological processes involved with disease progression and response to treatment.
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公开(公告)号：US20190170575A1
公开(公告)日：2019-06-06
申请号：US16271829
申请日：2019-02-10
发明人： Luca CAUCCI , Harrison BARRETT
摘要： The present invention provides methods and systems for manipulating radiance data obtained from a radiance sensor that includes a lenslet array and a photodetector array, where the manipulation of the radiance data uses one or more algorithms or mathematical transformations applied by a software program. Manipulating the measured radiance data computationally produces the same optical effects of a desired optical system without having to insert the optical system into the optical path of the electromagnetic radiation. The manipulated radiance data is then used to generate an image.
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