公开(公告)号：US20170232157A1

公开(公告)日：2017-08-17

申请号：US15430234

申请日：2017-02-10

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Kaushal Rege ,  Taraka Sai Pavan Grandhi ,  Jerry Crum ,  Russell Urie

IPC: A61L31/12 ,  A61L31/16 ,  A61L31/14 ,  A61B17/06 ,  A61B17/064

CPC classification number: A61L31/128 ,  A61B17/00491 ,  A61B17/06166 ,  A61B17/064 ,  A61B18/00 ,  A61B2017/00004 ,  A61B2017/00526 ,  A61B2017/00876 ,  A61B2017/00884 ,  A61B2018/00005 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16

Abstract: A tissue closure device can include a structural material and a stimulus responsive material on or in the structural material. The structural material can be biodegradable and/or bioabsorbable (e.g., biocompatible natural and/or semi-natural and/or synthetic polymer). The stimulus responsive material can be a particle, such as a nanoparticle. The structural material is shaped as a suture, staple, screw, patch, adhesive, sealant, or the like. A biologically active agent can be included. A method of promoting wound healing can include: approximating tissue portions; and stimulating the stimulus responsive material with a stimulus to cause the tissue portions of the wound to adhere to each other. The stimulus is selected from optical, electrical, thermal, chemical, mechanical, magnetic, acoustic, pressure, shear, biological, or enzymatic sources.