公开(公告)号：US11547997B2

公开(公告)日：2023-01-10

申请号：US16603338

申请日：2018-04-06

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Alexander A. Green ,  Matthew Gilliam ,  Kirstie Swingle ,  Nicholas Stephanopoulos ,  Neal Woodbury

IPC: B01L3/00 ,  C12Q1/70 ,  G01N33/543

Abstract: Integrated diagnostic devices comprising peptide-DNA conjugates for analyte detection, an embedded biomolecular computing system for sample analysis, and a layered device architecture are provided herein. In particular, provided herein are devices comprising a layered architecture that enables diagnostic reagents, sample components, and reaction products to flow through the system with minimal user intervention.

公开(公告)号：US20240094229A1

公开(公告)日：2024-03-21

申请号：US18463628

申请日：2023-09-08

Applicant: Arizona Board of Regents on Behalf of Arizona State University

Inventor： Alexander Green ,  Soma Chaudhary ,  Kirstie Swingle

IPC: G01N33/94 ,  C12Q1/6823 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543

CPC classification number: G01N33/9446 ,  C12Q1/6823 ,  G01N33/5308 ,  G01N33/542 ,  G01N33/54388

Abstract: Provided herein are highly modular and sensitive biosensors for small molecule detection using CRISPR/C as enzymes having collateral single-stranded nucleic acid cleavage activity. Also provided herein are uses of the biosensors in detection platforms for convenient, low-cost assessment of safety and purity of consumable samples, environmental samples, and agricultural products.