公开(公告)号：US20250002990A1

公开(公告)日：2025-01-02

申请号：US18709791

申请日：2022-11-14

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  ELECULAR LLC

Inventor： Quan QING ,  Peiming ZHANG

IPC: C12Q1/6869 ,  G16B30/00 ,  G16B40/10

Abstract: Disclosed are a nanopore-optical electronic device and a method for sequencing a biomolecule and modifications thereof. The nanopore-optical electronic device includes: a cis-fluidic chamber and a trans-fluidic chamber fabricated in a planar substrate; a nano-fluidic channel in between and connecting the cis-fluidic chamber and the trans-fluidic chamber; a first electrode and a second electrode sealed in the nano-fluidic channel and forming a nanogap/nanopore therebetween; a third electrode and fourth electrode disposed in the cis-fluidic chamber and the trans-fluidic chamber, respectively; an optical coupling element coupling an electromagnetic beam with the nanogap; an optical detector detecting an optical signal from the nanogap when a biomolecule translocates through the nanopore; and a current-measuring circuit concurrently measuring a tunneling current and ionic current when the biomolecule translocates through the nanopore. The recorded optical signal and tunneling current and ionic current signals are coincidental in time and colocalized in space.

公开(公告)号：US20250001384A1

公开(公告)日：2025-01-02

申请号：US18732594

申请日：2024-06-03

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Quan QING ,  Ching-wei TSAO ,  Peiming ZHANG

IPC: B01J19/00 ,  C07K1/04

Abstract: The present disclosure provides an apparatus for synthesizing a biopolymer, a method for preparing an apparatus for synthesizing a biopolymer, and a method of synthesizing a biopolymer.

公开(公告)号：US20240151682A1

公开(公告)日：2024-05-09

申请号：US18550881

申请日：2022-03-15

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Quan QING

IPC: G01N27/327 ,  B01L3/00

CPC classification number: G01N27/3278 ,  B01L3/502707 ,  B01L2300/0645 ,  B01L2300/0896 ,  B01L2400/0415

Abstract: Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties. In one example, disclosed are high density multiplexed chips with a plurality of groups, each group including a plurality of nanodevices, the chips capable of coupling to one or more multiwell structures for providing samples to each individual group. In this way, the chips can be used for high-throughput analysis of molecules such as DNA.