公开(公告)号：US20240345074A1

公开(公告)日：2024-10-17

申请号：US18631488

申请日：2024-04-10

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Alexander Star ,  Wenting Shao

IPC: G01N33/543 ,  G01N27/327 ,  G01N27/414 ,  G01N33/487

CPC classification number: G01N33/54346 ,  G01N27/3278 ,  G01N27/4145 ,  G01N27/4146 ,  G01N33/48714 ,  G01N2800/307

Abstract: A sensor device for detecting an antigen in a fluid sample includes a sensor including a substrate and a sensor medium on the substrate. The sensor medium includes a plurality of single-walled carbon nanotubes having an enriched semiconducting content and one or more antibody fragments immobilized on the plurality of single-walled carbon nanotubes. Each of the one or more antibody fragments includes an active binding site for the antigen. The sensor device further includes electronic circuitry including at least one measurement system in operative connection with the sensor to measure a variable providing a measure of change in at least one property of the sensor medium which is dependent upon the presence of the antigen.

公开(公告)号：US20240328990A1

公开(公告)日：2024-10-03

申请号：US18732126

申请日：2024-06-03

Applicant: AXBIO INC.

Inventor： Tao HONG ,  Igor Constantin IVANOV ,  Hui TIAN

IPC: G01N27/327 ,  C12Q1/6825 ,  C12Q1/6869 ,  C12Q1/6876

CPC classification number: G01N27/3278 ,  C12Q1/6825 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: The present disclosure provides systems and methods for analyzing or identifying a target nucleic acid molecule. For example, a system of the present disclosure may comprise (a) a complex comprising a target nucleic acid molecule and a primer nucleic acid molecule, wherein the primer nucleic acid molecule comprises (i) a region that is complementary to a portion of the target nucleic acid molecule and (ii) an additional region that is non-complementary the target nucleic acid molecule, and (b) with said additional region having flown through a pore of a sensor, using said sensor to identify said additional region, thereby analyzing said target nucleic acid molecule. The sensor may be configured to detect one or more signals indicative of an impedance or impedance change in the sensor when the at least the portion of the target molecule is bound by the binding unit. The one or more signals may be usable to analyze or identify the target molecule.

公开(公告)号：US12085558B2

公开(公告)日：2024-09-10

申请号：US17176371

申请日：2021-02-16

Applicant: The California State University—Northridge

Inventor： Hendrik Postma

IPC: G01N33/487 ,  B82Y15/00 ,  C12Q1/6869 ,  G01N27/327

CPC classification number: G01N33/48721 ,  C12Q1/6869 ,  G01N27/3278 ,  B82Y15/00

Abstract: Processes for conductive material nanogap formation have been developed that include: providing a base material, wherein the base material is either solid or comprises a micropore that extends through the first layered material, and wherein the micropore comprises a top opening, a bottom opening, and a volume boundary, applying a conductive material sheet to the first layered material, wherein the conductive material sheet covers the top opening of the micropore, applying two conducting electrodes to the conductive material sheet, so that each one of the conducting electrodes is positioned on either side of the micropore, applying an etch mask that covers at least a part of the conductive material sheet, the top opening of the micropore (if present), or a combination thereof, applying a passivation layer over at least the etch mask, fabricating a hole in the passivation layer directly above the top opening of the micropore, and applying at least one voltage pulse through the at least one conducting electrode to create a nanogap in the conductive material sheet, wherein the nanogap is over and open to the top opening of the micropore. In some embodiments, the micropore and the nanogap are fabricated simultaneously.

公开(公告)号：US20240230579A1

公开(公告)日：2024-07-11

申请号：US18311957

申请日：2023-05-04

Applicant: China Medical University ,  China Medical University Hospital

Inventor： Yi-Wen Chen ,  Yi-An Chen ,  Ming-You Shie

IPC: G01N27/327 ,  B82Y15/00 ,  B82Y30/00

CPC classification number: G01N27/3278 ,  B82Y15/00 ,  B82Y30/00

Abstract: An electrochemical biosensor has an electrode which is sequentially decorated a molybdenum (VI) oxide (MoO3) nanomaterial, a gold-composite nanomaterial, a carboxyl-sulfhydryl compound, and a carbodiimide/N-hydroxysuccinimide (EDC/NHS, EN) to modify the surface of the electrode. That the sulfhydryl group of the carboxyl-sulfhydryl compound forms a bond with the gold-composite nanomaterial, and the carbodiimide/N-hydroxybutanediimide forms a bond with a carboxyl group of the carboxyl-sulfhydryl compound.

公开(公告)号：US20240199437A1

公开(公告)日：2024-06-20

申请号：US18287190

申请日：2022-09-28

Applicant: YANSHAN UNIVERSITY

Inventor： Faming GAO ,  Yisong ZHAO ,  Kuo WEI ,  Xue ZUO ,  Yuping MI

IPC: C01G3/02 ,  G01N27/327

CPC classification number: C01G3/02 ,  G01N27/3271 ,  G01N27/3278 ,  C01P2002/72 ,  C01P2004/03 ,  C01P2004/04 ,  C01P2004/41 ,  C01P2004/64 ,  C01P2006/12 ,  C01P2006/40

Abstract: A copper oxide with a hollow porous structure, a preparation method therefor, and a use thereof are provided. The copper oxide with a hollow porous structure is of a hollow octahedral structure, and has a size of 200-400 nm and a specific surface area of 23.5-79.6 m2/g, where the surface of the octahedron is composed of copper oxide nanoparticles having a size of 14-33 nm, and pore structures are formed among the copper oxide nanoparticles. The copper oxide with the hollow porous structure has good conductivity, high hydrophilicity and good catalytic performance, can substantially reduce the detection potential and greatly improve the detection sensitivity and the anti-interference performance when used for the electrochemical detection of pesticides.

公开(公告)号：US20240151682A1

公开(公告)日：2024-05-09

申请号：US18550881

申请日：2022-03-15

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Quan QING

IPC: G01N27/327 ,  B01L3/00

CPC classification number: G01N27/3278 ,  B01L3/502707 ,  B01L2300/0645 ,  B01L2300/0896 ,  B01L2400/0415

Abstract: Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties. In one example, disclosed are high density multiplexed chips with a plurality of groups, each group including a plurality of nanodevices, the chips capable of coupling to one or more multiwell structures for providing samples to each individual group. In this way, the chips can be used for high-throughput analysis of molecules such as DNA.

公开(公告)号：US11940436B1

公开(公告)日：2024-03-26

申请号：US18212467

申请日：2023-06-21

Applicant: United Arab Emirates University

Inventor： Iltaf Shah ,  Afzal Shah

IPC: G01N33/15 ,  G01N27/30 ,  G01N27/327

CPC classification number: G01N33/15 ,  G01N27/308 ,  G01N27/3278

Abstract: The present disclosure discloses an electroanalytical sensor for the detection of meloxicam. The electroanalytical sensor comprises a carbon electrode. The carbon electrode comprises zinc oxide (ZnO) nanoparticles, wherein the ZnO nanoparticles are co-doped with silver (Ag) and cobalt (Co). The present disclosure also discloses a method of detecting meloxicam using an electroanalytical sensor. The electroanalytical sensor comprises a carbon electrode, the carbon electrode comprising zinc oxide (ZnO) nanoparticles co-doped with silver (Ag) and cobalt (Co). The method of detecting meloxicam comprises the step of positioning a liquid droplet, comprising solvent, to be tested on a surface of the electrode. The method further comprises receiving a voltammetric response from the electrode, and analysing the voltammetric response to determine if meloxicam is present in the liquid droplet.

公开(公告)号：US11933755B2

公开(公告)日：2024-03-19

申请号：US18054340

申请日：2022-11-10

Applicant: Industry-Academic Cooperation Foundation, Yonsei University

Inventor： Hyo-Il Jung ,  Kyungyeon Lee

IPC: G01N27/327 ,  C25D3/48 ,  C25D5/48 ,  C25D7/00 ,  G01N27/30 ,  G01N33/53 ,  G01N33/543

CPC classification number: G01N27/3276 ,  C25D3/48 ,  C25D5/48 ,  C25D7/00 ,  G01N27/308 ,  G01N27/3278 ,  G01N33/5308 ,  G01N33/5438

Abstract: Provided is an electrochemical aptasensor for detecting di(2-ethylhexyl)phthalate (DEHP) with high sensitivity. The electrochemical aptasensor according to the present invention has a low detection limit concentration by improving sensitivity by sensor surface modification using a nano composite and gold nanoflowers, and has high practical applicability of a sensor by monitoring a trace amount of DEHP migrating from a real plastic product by a simple measurement method.

公开(公告)号：US11906461B2

公开(公告)日：2024-02-20

申请号：US17043175

申请日：2019-03-29

Applicant: TOYOBO CO., LTD. ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Katsumi Tsuji ,  Keizo Yoneda ,  Atsushi Sogabe ,  Atsunori Hiratsuka ,  Hitoshi Muguruma ,  Hisanori Iwasa ,  Takeshi Tanaka ,  Kouhei Orihara

IPC: G01N27/327 ,  C01B32/159 ,  C01B32/168 ,  C12Q1/00 ,  C12Q1/32 ,  G01N27/30 ,  B82Y15/00 ,  B82Y40/00

CPC classification number: G01N27/3278 ,  C01B32/159 ,  C01B32/168 ,  C12Q1/005 ,  C12Q1/32 ,  C12Y101/05 ,  G01N27/308 ,  B82Y15/00 ,  B82Y40/00 ,  C01B2202/02 ,  C01B2202/22

Abstract: Provided is a means for promoting electron transfer between nanocarbon and other substances. An electron transfer accelerator for nanocarbon comprising a compound having an aromatic ring Skelton.

公开(公告)号：US20240018190A1

公开(公告)日：2024-01-18

申请号：US17373763

申请日：2020-01-10

Applicant: Roswell Biotechnologies, Inc.

Inventor： Barry Merriman ,  Tim Geiser ,  Venkatesh Alagarswarmy Govindaraj

IPC: C07K14/00 ,  G01N27/327 ,  C12Q1/6869

CPC classification number: C07K14/001 ,  G01N27/3278 ,  C12Q1/6869 ,  C07K2319/43 ,  C07K2319/50

Abstract: In various embodiments, a synthetic peptide finding use as a molecular wire in a molecular electronic circuit comprises an alpha helical segment further comprising repeating alpha-helical motifs. The synthetic peptide may further comprise at least one specific conjugation site between the termini for attachment to a molecule such as a binding probe, and may further comprise termini having metal binding functionality such as repeats of material binding sequences. In various aspects, the synthetic peptide comprises intramolecular hydrogen bonding, salt bridges, and optionally, aromatic rings that provide for electrical conductivity through the peptide.