-
公开(公告)号：US11208640B2
公开(公告)日：2021-12-28
申请号：US16632782
申请日：2018-04-27
Inventor： Radwa Ewaisha , Samira Kiani , Shayesteh Roshdi Ferdosi , Karen Anderson , Farzaneh Moghadam , Sri Krishna , Mo Reza Ebrahimkhani
IPC: C12N9/22 , G01N33/573 , A61K48/00
Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.
-
公开(公告)号：US20240368572A1
公开(公告)日：2024-11-07
申请号：US18778083
申请日：2024-07-19
Inventor： Radwa Ewaisha , Samira Kiani , Shayesteh Roshdi Ferdosi , Karen Anderson , Farzaneh Moghadam , Sri Krishna , Mo Reza Ebrahimkhani
IPC: C12N9/22 , A61K48/00 , G01N33/573
Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.
-
Patent Agency Ranking
公开(公告)号：US20200377871A1
公开(公告)日：2020-12-03
申请号：US16632782
申请日：2018-04-27
Inventor： Radwa Ewaisha , Samira Kiani , Shayesteh Roshdi Ferdosi , Karen Anderson , Farzaneh Moghadam , Sri Krishna , Mo Reza Ebrahimkhani
IPC: C12N9/22 , G01N33/573
Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.
-
公开(公告)号：US20180320230A1
公开(公告)日：2018-11-08
申请号：US15770323
申请日：2016-10-27
Inventor： Joshua LaBaer , Karen Anderson , Ji Qiu , Sri Krishna
IPC: C12Q1/6881 , G01N33/569 , G01N33/554
CPC classification number: C12Q1/6881 , G01N33/554 , G01N33/56972
Abstract: Provided herein are methods of classifying antigens and epitopes as being recognized by an individual's cellular immune response. More particularly, provided herein are methods for unbiased determination of which antigens are recognized by a population of T cells.
-
公开(公告)号：US12084691B2
公开(公告)日：2024-09-10
申请号：US17546810
申请日：2021-12-09
Inventor： Radwa Ewaisha , Samira Kiani , Shayesteh Roshdi Ferdosi , Karen Anderson , Farzaneh Moghadam , Sri Krishna , Mo Reza Ebrahimkhani
IPC: C12N9/22 , A61K48/00 , G01N33/573
CPC classification number: C12N9/22 , G01N33/573 , A61K48/00 , C12N2310/20 , C12N2800/80 , G01N2333/922
Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.
-
公开(公告)号：US11524063B2
公开(公告)日：2022-12-13
申请号：US16762085
申请日：2018-11-15
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , BAYLOR COLLEGE OF MEDICINE
Inventor： Sri Krishna , Marshall Posner , Andrew Sikora , Karen Anderson
Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.
-
公开(公告)号：US20220162574A1
公开(公告)日：2022-05-26
申请号：US17546810
申请日：2021-12-09
Inventor： Samira Kiani , Radwa Ewaisha , Shayesteh Roshdi Ferdosi , Karen Anderson , Farzaneh Moghadam , Sri Krishna , Mohammad R Ebrahimkhani
IPC: C12N9/22 , G01N33/573
Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.
-
-
-
-
-
-
Search Results
7
records
(took 0.02 seconds)
