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公开(公告)号：US08871754B2
公开(公告)日：2014-10-28
申请号：US14083203
申请日：2013-11-18
申请人： Arnab Kumar Chatterjee , Advait Suresh Nagle , Prasuna Paraselli , Ravinder Reddy Kondreddi , Seh Yong Leong , Pranab Kumar Mishra , Robert Joseph Moreau , Jason Thomas Roland , Wei Lin Sandra Sim , Oliver Simon , Liying Jocelyn Tan , Bryan K S Yeung , Bin Zou , Venkatataiah Bollu
发明人： Arnab Kumar Chatterjee , Advait Suresh Nagle , Prasuna Paraselli , Ravinder Reddy Kondreddi , Seh Yong Leong , Pranab Kumar Mishra , Robert Joseph Moreau , Jason Thomas Roland , Wei Lin Sandra Sim , Oliver Simon , Liying Jocelyn Tan , Bryan K S Yeung , Bin Zou , Venkatataiah Bollu
IPC分类号： C07D471/04 , A61K31/506 , A61K31/538 , A61K31/437 , A61K45/06
CPC分类号： A61K31/437 , A61K31/444 , A61K31/538 , A61K45/06 , C07D471/04 , C07D519/00 , Y02A50/411 , A61K2300/00
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。
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公开(公告)号：US20150011522A1
公开(公告)日：2015-01-08
申请号：US14492736
申请日：2014-09-22
申请人： Arnab Kumar Chatterjee , Advait Suresh Nagle , Prasuna Paraselli , Ravinder Reddy Kondreddi , Seh Yong Leong , Pranab Kumar Mishra , Robert Joseph Moreau , Jason Thomas Roland , Wei Lin Sandra Sim , Oliver Simon , Liying Jocelyn Tan , Bryan KS Yeung , Bin Zou , Venkatataiah Bollu
发明人： Arnab Kumar Chatterjee , Advait Suresh Nagle , Prasuna Paraselli , Ravinder Reddy Kondreddi , Seh Yong Leong , Pranab Kumar Mishra , Robert Joseph Moreau , Jason Thomas Roland , Wei Lin Sandra Sim , Oliver Simon , Liying Jocelyn Tan , Bryan KS Yeung , Bin Zou , Venkatataiah Bollu
IPC分类号： A61K31/437 , A61K31/538 , A61K45/06 , C07D471/04
CPC分类号： A61K31/437 , A61K31/444 , A61K31/538 , A61K45/06 , C07D471/04 , C07D519/00 , Y02A50/411 , A61K2300/00
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.
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公开(公告)号：US20140155367A1
公开(公告)日：2014-06-05
申请号：US14083203
申请日：2013-11-18
申请人： Arnab Kumar Chatterjee , Advait Suresh Nagle , Prasuna Paraselli , Ravinder Reddy Kondreddi , Seh Yong Leong , Pranab Kumar Mishra , Robert Joseph Moreau , Jason Thomas Roland , Wei Lin Sandra Sim , Oliver Simon , Liying Jocelyn Tan , Bryan KS Yeung , Bin Zou , Venkatataiah Bollu
发明人： Arnab Kumar Chatterjee , Advait Suresh Nagle , Prasuna Paraselli , Ravinder Reddy Kondreddi , Seh Yong Leong , Pranab Kumar Mishra , Robert Joseph Moreau , Jason Thomas Roland , Wei Lin Sandra Sim , Oliver Simon , Liying Jocelyn Tan , Bryan KS Yeung , Bin Zou , Venkatataiah Bollu
IPC分类号： C07D471/04 , A61K31/506 , A61K31/538 , A61K31/437 , A61K45/06
CPC分类号： A61K31/437 , A61K31/444 , A61K31/538 , A61K45/06 , C07D471/04 , C07D519/00 , Y02A50/411 , A61K2300/00
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。
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4.发明申请公开(公告)号：US20150291526A1
公开(公告)日：2015-10-15
申请号：US14648217
申请日：2013-12-12
申请人： Ravinder Reddy KONDREDDI , Ujjini H. MANJUNATHA , Ngai Ling MA , Stefan PEUKERT , Srinivasa PS RAO
发明人： Ravinder Reddy Kondreddi , Ngai Ling Ma , Stefan Peukert , Srinivasa P S Rao , Manjunatha Ujjini
IPC分类号： C07D213/69 , C07D405/06 , A61K31/4433 , A61K45/06 , C07F9/58 , A61K31/675 , C07D401/04 , A61K31/4439 , A61K31/4412 , A61K31/444
CPC分类号： C07D213/69 , A61K31/4412 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/675 , A61K45/06 , C07D213/64 , C07D401/04 , C07D401/06 , C07D405/06 , C07F9/58
摘要： A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the inhibition of mycolic acid biosynthesis through inhibition of M. tuberculosis Enoyl Acyl Carrier Protein Reductase enzyme (InhA): wherein R1, R2, R3, R4 and R5 are as defined herein.
摘要翻译： 提供式（I）的化合物，其已被证明可用于治疗通过抑制结核分枝杆菌乙酰基酰基载体蛋白还原酶（InhA）而抑制霉菌酸生物合成介导的疾病，病症或综合征： 其中R1，R2，R3，R4和R5如本文所定义。
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5.发明授权公开(公告)号：US09546138B2
公开(公告)日：2017-01-17
申请号：US14648217
申请日：2013-12-12
申请人： Ravinder Reddy Kondreddi , Ngai Ling Ma , Stefan Peukert , Srinivasa P S Rao , Manjunatha Ujjini
发明人： Ravinder Reddy Kondreddi , Ngai Ling Ma , Stefan Peukert , Srinivasa P S Rao , Manjunatha Ujjini
IPC分类号： C07D213/69 , C07F9/58 , C07D401/06 , C07D405/06 , C07D213/64 , A61K31/4412 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/675 , A61K45/06 , C07D401/04
CPC分类号： C07D213/69 , A61K31/4412 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/675 , A61K45/06 , C07D213/64 , C07D401/04 , C07D401/06 , C07D405/06 , C07F9/58
摘要： A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the inhibition of mycolic acid biosynthesis through inhibition of M. tuberculosis Enoyl Acyl Carrier Protein Reductase enzyme (InhA): wherein R1, R2, R3, R4 and R5 are as defined herein.
摘要翻译： 提供式（I）的化合物，其已被证明可用于治疗通过抑制结核分枝杆菌乙酰基酰基载体蛋白还原酶（InhA）而抑制霉菌酸生物合成介导的疾病，病症或综合征： 其中R1，R2，R3，R4和R5如本文所定义。
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公开(公告)号：US09447039B2
公开(公告)日：2016-09-20
申请号：US14420074
申请日：2013-09-05
IPC分类号： C07D209/12 , C07D209/42 , A61K31/4045 , A61K31/407 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D491/056
CPC分类号： C07D209/42 , A61K31/404 , A61K31/4045 , A61K31/407 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D491/056
摘要： A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway: wherein R1, R2, R3, R4, R5 and R6 are as defined herein.
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公开(公告)号：US20160355477A1
公开(公告)日：2016-12-08
申请号：US15242160
申请日：2016-08-19
IPC分类号： C07D209/42 , A61K31/5377 , A61K31/407 , A61K31/454 , A61K31/404 , C07D491/056
CPC分类号： C07D209/42 , A61K31/404 , A61K31/4045 , A61K31/407 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D491/056
摘要： A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway: wherein R1, R2, R3, R4, R5 and R6 are as defined herein.
摘要翻译： 其中R1，R2，R3，R4，R5和R6如本文所定义。
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公开(公告)号：US20150175539A1
公开(公告)日：2015-06-25
申请号：US14420074
申请日：2013-09-05
IPC分类号： C07D209/42 , C07D491/056 , A61K45/06 , A61K31/5377 , A61K31/454 , A61K31/4045 , A61K31/407
CPC分类号： C07D209/42 , A61K31/404 , A61K31/4045 , A61K31/407 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D491/056
摘要： A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway: wherein R1, R2, R3, R4, R5 and R6 are as defined herein.
摘要翻译： 提供了式（I）化合物，其已被证明可用于治疗通过在MMPL3途径中运输必需分子介导的疾病，病症或综合征：其中R1，R2，R3，R4，R5和R6 如本文所定义。
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