公开(公告)号：US20140155367A1

公开(公告)日：2014-06-05

申请号：US14083203

申请日：2013-11-18

申请人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan KS Yeung ,  Bin Zou ,  Venkatataiah Bollu

发明人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan KS Yeung ,  Bin Zou ,  Venkatataiah Bollu

IPC分类号： C07D471/04 ,  A61K31/506 ,  A61K31/538 ,  A61K31/437 ,  A61K45/06

CPC分类号： A61K31/437 ,  A61K31/444 ,  A61K31/538 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/411 ,  A61K2300/00

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。

公开(公告)号：US20150011522A1

公开(公告)日：2015-01-08

申请号：US14492736

申请日：2014-09-22

申请人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan KS Yeung ,  Bin Zou ,  Venkatataiah Bollu

发明人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan KS Yeung ,  Bin Zou ,  Venkatataiah Bollu

IPC分类号： A61K31/437 ,  A61K31/538 ,  A61K45/06 ,  C07D471/04

CPC分类号： A61K31/437 ,  A61K31/444 ,  A61K31/538 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/411 ,  A61K2300/00

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

公开(公告)号：US08871754B2

公开(公告)日：2014-10-28

申请号：US14083203

申请日：2013-11-18

申请人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan K S Yeung ,  Bin Zou ,  Venkatataiah Bollu

发明人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan K S Yeung ,  Bin Zou ,  Venkatataiah Bollu

IPC分类号： C07D471/04 ,  A61K31/506 ,  A61K31/538 ,  A61K31/437 ,  A61K45/06

CPC分类号： A61K31/437 ,  A61K31/444 ,  A61K31/538 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/411 ,  A61K2300/00

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。

公开(公告)号：US09682939B2

公开(公告)日：2017-06-20

申请号：US15034280

申请日：2014-11-04

申请人： Donatella Chianelli ,  Xiaodong Liu ,  Valentina Molteni ,  John Nelson ,  Jason Thomas Roland ,  Paul Vincent Rucker ,  David Charles Tully

发明人： Donatella Chianelli ,  Xiaodong Liu ,  Valentina Molteni ,  John Nelson ,  Jason Thomas Roland ,  Paul Vincent Rucker ,  David Charles Tully

IPC分类号： C07D231/54 ,  C07D491/052 ,  C07D471/06 ,  A61K31/4162 ,  A61K31/4745 ,  A61K31/4439 ,  C07D471/04 ,  A61K31/416

CPC分类号： C07D231/54 ,  A61K31/416 ,  A61K31/4162 ,  A61K31/4439 ,  A61K31/4745 ,  C07D471/04 ,  C07D471/06 ,  C07D491/052

摘要： The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).