公开(公告)号：US08871754B2

公开(公告)日：2014-10-28

申请号：US14083203

申请日：2013-11-18

申请人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan K S Yeung ,  Bin Zou ,  Venkatataiah Bollu

发明人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan K S Yeung ,  Bin Zou ,  Venkatataiah Bollu

IPC分类号： C07D471/04 ,  A61K31/506 ,  A61K31/538 ,  A61K31/437 ,  A61K45/06

CPC分类号： A61K31/437 ,  A61K31/444 ,  A61K31/538 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/411 ,  A61K2300/00

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。

公开(公告)号：US20150011522A1

公开(公告)日：2015-01-08

申请号：US14492736

申请日：2014-09-22

申请人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan KS Yeung ,  Bin Zou ,  Venkatataiah Bollu

发明人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan KS Yeung ,  Bin Zou ,  Venkatataiah Bollu

IPC分类号： A61K31/437 ,  A61K31/538 ,  A61K45/06 ,  C07D471/04

CPC分类号： A61K31/437 ,  A61K31/444 ,  A61K31/538 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/411 ,  A61K2300/00

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

公开(公告)号：US20140155367A1

公开(公告)日：2014-06-05

申请号：US14083203

申请日：2013-11-18

申请人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan KS Yeung ,  Bin Zou ,  Venkatataiah Bollu

发明人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan KS Yeung ,  Bin Zou ,  Venkatataiah Bollu

IPC分类号： C07D471/04 ,  A61K31/506 ,  A61K31/538 ,  A61K31/437 ,  A61K45/06

CPC分类号： A61K31/437 ,  A61K31/444 ,  A61K31/538 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/411 ,  A61K2300/00

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。

公开(公告)号：US09186361B2

公开(公告)日：2015-11-17

申请号：US14209655

申请日：2014-03-13

申请人： Arnab Kumar Chatterjee ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Pranab Kumar Mishra ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Liying Jocelyn Tan ,  Agnes Vidal

发明人： Arnab Kumar Chatterjee ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Pranab Kumar Mishra ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Liying Jocelyn Tan ,  Agnes Vidal

IPC分类号： A01N43/42 ,  A61K31/44 ,  A61K31/5377 ,  A61K31/437 ,  A61K45/06 ,  C07D471/04 ,  C07D498/04

CPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K45/06 ,  C07D471/04 ,  C07D498/04 ,  Y02A50/409 ,  Y02A50/414 ,  Y02A50/415

摘要： The present invention provides compounds of Formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和查加斯 疾病。

公开(公告)号：US09233961B2

公开(公告)日：2016-01-12

申请号：US14209536

申请日：2014-03-13

申请人： Arnab Kumar Chatterjee ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Pranab Kumar Mishra ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Liying Jocelyn Tan ,  Agnes Vidal ,  Michael Herman Gelb ,  Frederick Simmons Buckner ,  Hari Babu Tatipaka ,  Neil Richard Norcross ,  John Robert Gillespie

发明人： Arnab Kumar Chatterjee ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Pranab Kumar Mishra ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Liying Jocelyn Tan ,  Agnes Vidal ,  Michael Herman Gelb ,  Frederick Simmons Buckner ,  Hari Babu Tatipaka ,  Neil Richard Norcross ,  John Robert Gillespie

IPC分类号： C07D471/02 ,  A61K31/50 ,  A61K31/415 ,  C07D473/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

CPC分类号： C07D473/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

公开(公告)号：US08399453B2

公开(公告)日：2013-03-19

申请号：US13186035

申请日：2011-07-19

申请人： Shi Hua Ang ,  Philipp Krastel ,  Seh Yong Leong ,  Liying Jocelyn Tan ,  Wei Lin Josephine Wong ,  Bryan K. S. Yeung ,  Bin Zou

发明人： Shi Hua Ang ,  Philipp Krastel ,  Seh Yong Leong ,  Liying Jocelyn Tan ,  Wei Lin Josephine Wong ,  Bryan K. S. Yeung ,  Bin Zou

IPC分类号： A61K31/55 ,  A61K31/407 ,  A61K31/438 ,  C07D471/20 ,  C07D487/20

CPC分类号： C07D471/20 ,  C07D487/20 ,  C07D498/22

摘要： The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi and parasites of the Leishmania genus such as, for example. Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.

摘要翻译： 本发明涉及具有有趣的药物性质的有机化合物。 特别地，这些化合物可用于治疗和/或预防诸如由恶性疟原虫，间日疟原虫，疟原虫，疟原虫，克氏锥虫和利什曼原虫属的寄生虫引起的感染。 利什曼原虫donovani。 本发明还涉及含有化合物的药物组合物及其制备方法。

公开(公告)号：US09296754B2

公开(公告)日：2016-03-29

申请号：US14209850

申请日：2014-03-13

申请人： Fang Liang ,  Pranab Kumar Mishra ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Liying Jocelyn Tan ,  Agnes Vidal

发明人： Fang Liang ,  Pranab Kumar Mishra ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Liying Jocelyn Tan ,  Agnes Vidal

IPC分类号： A61K31/519 ,  C07D487/04 ,  A61K45/06

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  Y02A50/409 ,  Y02A50/414 ,  Y02A50/415 ,  A61K2300/00

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和查加斯 疾病。

公开(公告)号：US08053442B2

公开(公告)日：2011-11-08

申请号：US12430625

申请日：2009-04-27

申请人： Shi Hua Ang ,  Philipp Krastel ,  Seh Yong Leong ,  Liying Jocelyn Tan ,  Wei Lin Josephine Wong ,  Bryan KS Yeung ,  Bin Zou

发明人： Shi Hua Ang ,  Philipp Krastel ,  Seh Yong Leong ,  Liying Jocelyn Tan ,  Wei Lin Josephine Wong ,  Bryan KS Yeung ,  Bin Zou

IPC分类号： A61K31/438 ,  C07D471/20

CPC分类号： C07D471/20 ,  C07D487/20 ,  C07D498/22

摘要： The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi and parasites of the Leishmania genus such as, for example, Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.

摘要翻译： 本发明涉及具有有趣的药物性质的有机化合物。 特别地，这些化合物可用于治疗和/或预防诸如由恶性疟原虫，间日疟原虫，疟疾疟原虫，疟原虫，克氏锥虫和利什曼原虫属的寄生虫如杜氏利什曼原虫引起的感染的治疗和/或预防。 本发明还涉及含有化合物的药物组合物及其制备方法。