公开(公告)号：US20120058500A1

公开(公告)日：2012-03-08

申请号：US13255857

申请日：2010-03-10

申请人： Arnan Deane Mitchell ,  Francisco Javier Tovar Lopez ,  Shaun Phillip Jackson ,  Warwick Scott Nesbitt ,  Josie Carberry

发明人： Arnan Deane Mitchell ,  Francisco Javier Tovar Lopez ,  Shaun Phillip Jackson ,  Warwick Scott Nesbitt ,  Josie Carberry

IPC分类号： C12Q1/56 ,  C12M1/34 ,  C12Q1/34 ,  C12Q1/02

CPC分类号： B01L3/502761 ,  B01L3/502707 ,  B01L3/502746 ,  B01L3/502776 ,  B01L2300/0654 ,  B01L2300/1827 ,  B01L2400/0457 ,  B01L2400/0475 ,  B01L2400/086 ,  G01N21/82

摘要： A microfluidics device to provide real time monitoring of platelet aggregation of a biological sample obtained from a subject. The device comprises a channel configured for passage of the biological sample, the channel comprising a protrusion configured to induce an upstream region of shear acceleration coupled to a downstream region of shear deceleration and defining there-between a region of peak rate of shear, the downstream region of shear deceleration defining a zone of platelet aggregation. The device further comprises a platelet detection means for detecting aggregation of platelets in the zone of aggregation as a result of passage of the biological sample through the channel. Methods to assess real time platelet aggregation of a biological sample obtained from a subject are further described.

摘要翻译： 一种用于提供从受试者获得的生物样品的血小板聚集的实时监测的微流体装置。 所述装置包括被配置用于通过所述生物样品的通道，所述通道包括突出部，所述突起被配置为引起耦合到剪切减速度的下游区域的剪切加速的上游区域，并且在所述剪切速度的峰值速率区域之间限定，所述下游区域 剪切减速区限定血小板聚集区。 该装置还包括血小板检测装置，用于检测由于生物样品通过通道而导致聚集区域中血小板的聚集。 进一步描述评估从受试者获得的生物样品的实时血小板聚集的方法。