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公开(公告)号:US07547763B2
公开(公告)日:2009-06-16
申请号:US11497168
申请日:2006-08-01
申请人: Arnd Baumann , Wolfgang Bonigk , Renate Gauss , Alexander Scholten , Reinhard Seifert , Benjamin Kaupp
发明人: Arnd Baumann , Wolfgang Bonigk , Renate Gauss , Alexander Scholten , Reinhard Seifert , Benjamin Kaupp
CPC分类号: C07K14/43581 , A61K38/00 , A61K48/00 , C07K14/43504 , C07K14/705
摘要: The present invention relates to an isolated or purified human nucleic acid, preferably a DNA, comprising a nucleotide sequence encoding an Ih ion channel. The invention further relates to a vector comprising the isolated or purified nucleic acid, a host cell comprising the vector, and a composition comprising the isolated or purified nucleic acid and a carrier therefore. The invention also provides a polypeptide or protein encoded by the nucleic acid, and a method of treating a mammal for a cardiovascular disorder.
摘要翻译: 本发明涉及分离或纯化的人核酸,优选DNA,其包含编码Ih离子通道的核苷酸序列。 本发明还涉及包含分离或纯化的核酸的载体,包含载体的宿主细胞,以及包含分离或纯化的核酸和载体的组合物。 本发明还提供了由核酸编码的多肽或蛋白质,以及治疗哺乳动物心血管疾病的方法。
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公开(公告)号:US20060269959A1
公开(公告)日:2006-11-30
申请号:US11497168
申请日:2006-08-01
申请人: Arnd Baumann , Wolfgang Bonigk , Renate Gauss , Alexander Scholten , Reinhard Seifert , Benjamin Kaupp
发明人: Arnd Baumann , Wolfgang Bonigk , Renate Gauss , Alexander Scholten , Reinhard Seifert , Benjamin Kaupp
CPC分类号: C07K14/43581 , A61K38/00 , A61K48/00 , C07K14/43504 , C07K14/705
摘要: The present invention relates to an isolated or purified human nucleic acid, preferably a DNA, comprising a nucleotide sequence encoding an Ih ion channel. The invention further relates to a vector comprising the isolated or purified nucleic acid, a host cell comprising the vector, and a composition comprising the isolated or purified nucleic acid and a carrier therefore. The invention also provides a polypeptide or protein encoded by the nucleic acid, and a method of treating a mammal for a cardiovascular disorder.
摘要翻译: 本发明涉及分离或纯化的人核酸,优选DNA,其包含编码I H h离子通道的核苷酸序列。 本发明还涉及包含分离或纯化的核酸的载体,包含载体的宿主细胞,以及包含分离或纯化的核酸和载体的组合物。 本发明还提供了由核酸编码的多肽或蛋白质,以及治疗哺乳动物心血管疾病的方法。
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公开(公告)号:US07112667B1
公开(公告)日:2006-09-26
申请号:US09640582
申请日:2000-08-17
申请人: Arnd Baumann , Wolfgang Bönigk , Renate Gauss , Alexander Scholten , Reinhard Seifert , Benjamin Kaupp
发明人: Arnd Baumann , Wolfgang Bönigk , Renate Gauss , Alexander Scholten , Reinhard Seifert , Benjamin Kaupp
IPC分类号: C07H21/04 , C12N15/63 , C12N1/15 , C12N15/12 , G01N33/566
CPC分类号: C07K14/43581 , A61K38/00 , A61K48/00 , C07K14/43504 , C07K14/705
摘要: The present invention relates to a nucleic acid, preferably a DNA, comprising at least a part of the sequence of an Ih ion channel. Said sequence may e.g. be derived from a human DNA, a rat DNA, a bovine DNA, a Drosophila melanogaster DNA or a sea urchin DNA. Furthermore, the present invention relates to an mRNA molecule which contains the corresponding sequences. The invention further relates to a polypeptide or protein encoded by the nucleic acid.Furthermore, the invention relates to the use of the inventive nucleic acid and proteins for a screening and/or diagnosing method and to the kits required therefor.Lastly, the invention relates to the use of one or more nucleic acids and proteins for the treatment and/or prophylaxis of cardiovascular disorders and disturbances of consciousness.
摘要翻译: 本发明涉及一种核酸,优选DNA,其包含至少一部分I H H离子通道的序列。 所述序列可以例如。 衍生自人类DNA,大鼠DNA,牛DNA,果蝇黑腹果蝇DNA或海胆DNA。 此外,本发明涉及含有相应序列的mRNA分子。 本发明还涉及由该核酸编码的多肽或蛋白质。 此外,本发明涉及本发明的核酸和蛋白质用于筛选和/或诊断方法及其所需的试剂盒的用途。 最后,本发明涉及一种或多种核酸和蛋白质用于治疗和/或预防心血管疾病和意识障碍的用途。
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公开(公告)号:US4382021A
公开(公告)日:1983-05-03
申请号:US324983
申请日:1981-11-25
申请人: Peter R. Laurer , Gerd Krome , Luc Cordemans , Reinhard Seifert , Eckehard Danz
发明人: Peter R. Laurer , Gerd Krome , Luc Cordemans , Reinhard Seifert , Eckehard Danz
IPC分类号: C07C17/156 , B01J23/78 , C07B61/00 , C07C17/00 , C07C17/154 , C07C19/045 , C07C67/00 , B01J27/10
CPC分类号: B01J23/78 , C07C17/154
摘要: A supported catalyst containing copper and alkali metals, wherein the content of copper is from 1.0 to 12% by weight, based on total catalyst and expressed as metal, and the total content of the alkali metals potassium, lithium and sodium is from 0.3 to 9% by weight, based on total catalyst.The novel catalyst is useful for the preparation of 1,2-dichloroethane by oxychlorination of ethylene.
摘要翻译: 一种含有铜和碱金属的负载催化剂,其中铜的含量为1.0-12重量%,以总催化剂计,以金属表示,碱金属钾,锂和钠的总含量为0.3-9 重量%,基于总催化剂。 该新型催化剂可用于通过乙烯氧氯化制备1,2-二氯乙烷。
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