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    Hydrogels for orthopedic repair
    1.
    发明申请
    Hydrogels for orthopedic repair 审中-公开
    用于整形外科修复的水凝胶

    公开(公告)号：US20060093648A1

    公开(公告)日：2006-05-04

    申请号：US11301055

    申请日：2005-12-12

    申请人： Arthur Coury ,  Stephen Goodrich ,  Hildegard Kramer ,  Luis Avila ,  John Traverse ,  Peter Jarrett

    发明人： Arthur Coury ,  Stephen Goodrich ,  Hildegard Kramer ,  Luis Avila ,  John Traverse ,  Peter Jarrett

    IPC分类号： A61F2/00 ,  A61K47/48 ,  C08F4/28

    CPC分类号： A61K9/06

    摘要： Hydrogels intended for orthopedic applications, including repair and regeneration of cartilage, bone, joint surfaces and related tissues, must possess greater strength and toughness than hydrogels used in soft tissue repair. A hydrogel formulation is provided which has high strength, toughness, a suitable mechanical modulus and low equilibrium hydration. It may also have controlled porosity or degradation time. It can be made to polymerize in situ with high (“good” to “excellent”) adherence to target tissue or surfaces. A preferred formulation for forming such gels comprises 40 to 80% by weight of a low-molecular weight polar monomer and 30 to 10% of a hydrophilic macromeric crosslinker.

    摘要翻译： 用于矫形应用的水凝胶，包括软骨，骨，关节表面和相关组织的修复和再生，必须具有比在软组织修复中使用的水凝胶更大的强度和韧性。 提供了具有高强度，韧性，合适的机械模量和低平衡水合的水凝胶制剂。 它也可能具有受控的孔隙率或降解时间。 它可以使得在目标组织或表面上具有高（“良好”至“优异”）粘附的原位聚合。 用于形成这种凝胶的优选制剂包含40至80重量％的低分子量极性单体和30至10重量％的亲水性大分子交联剂。

    Adherent polymeric compositions
    2.
    发明申请
    Adherent polymeric compositions 审中-公开
    粘附聚合物组合物

    公开(公告)号：US20050281866A1

    公开(公告)日：2005-12-22

    申请号：US11136328

    申请日：2005-05-23

    申请人： Peter Jarrett ,  Kenneth Messier ,  Robert Miller ,  C. Philbrook ,  Hildegard Kramer ,  J. Kablik ,  Erika Johnston ,  Luis Avila ,  Arthur Coury

    发明人： Peter Jarrett ,  Kenneth Messier ,  Robert Miller ,  C. Philbrook ,  Hildegard Kramer ,  J. Kablik ,  Erika Johnston ,  Luis Avila ,  Arthur Coury

    IPC分类号： A61L15/16 ,  A61L24/00 ,  A61L24/04 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10

    CPC分类号： A61L31/06 ,  A61L24/0042 ,  A61L24/043 ,  A61L27/34 ,  A61L31/10 ,  C08L71/02

    摘要： Described herein are adhesive polymeric compositions and methods for using the compositions. The composition are adherent to the applied surface. The compositions, in certain embodiments, are biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications. The adherent polymeric compositions comprise a polymerized macromer network and an additive mixed or entangled in the polymerized macromer. The additive is bonded to a surface by at least one covalent bond or by secondary interactions and is not covalently bonded to the polymerized macromer network. Alternatively, the additive is bonded to the surface by at least one covalent bond and is also bonded to the macromer network. The disclosed compositions can be used as an improved barrier, coating or drug delivery system that due to the additive is highly adherent to an applied surface. The compositions of the present invention are typically non-toxic, water miscible and have adaptable characteristics depending on the macromers and additives used. For example, specific macromers can be used for targeted bioresorption rate and/or degradation rate of the applied composition.

    摘要翻译： 本文描述的是粘合聚合物组合物和使用该组合物的方法。 组合物附着在所施加的表面上。 在某些实施方案中，组合物是可生物降解的和生物相容的，并且可以设计成具有针对不同手术和治疗应用的选择性的适应性和弹性。 粘附的聚合物组合物包含聚合的大分子单体网络和在聚合的大分子单体中混合或缠结的添加剂。 添加剂通过至少一个共价键或通过二次相互作用结合到表面上，并且不共价键合到聚合的大分子单体网络上。 或者，添加剂通过至少一个共价键与表面键合，并且也结合到大分子单体网络上。 所公开的组合物可以用作改进的屏障，涂层或药物递送系统，由于添加剂与施加的表面高度粘附。 根据所使用的大分子单体和添加剂，本发明的组合物通常是无毒的，水可混溶的并具有适应性的特性。 例如，特定的大分子单体可用于所应用组合物的靶向生物再吸收速率和/或降解速率。

    Controlled release of anti-arrhythmic agents
    4.
    发明申请
    Controlled release of anti-arrhythmic agents 审中-公开
    抗心律不齐药物的控制释放

    公开(公告)号：US20060093673A1

    公开(公告)日：2006-05-04

    申请号：US10533179

    申请日：2003-06-27

    申请人： Arthur Coury ,  C Philbrook ,  Kevin Skinner

    发明人： Arthur Coury ,  C Philbrook ,  Kevin Skinner

    IPC分类号： A61K9/14

    CPC分类号： A61K9/0024 ,  A61K9/7023 ,  A61K47/32

    摘要： Methods for the simple, reliable application and local controlled release of selected anti-arrhythmia drugs from a hydrogel applied to or polymerized on the tissues of the heart or its vessels, especially in conjunction with cardiac bypass or other cardiac surgery, have been developed. The anti-arrhythmia drugs are incorporated along with an anti-inflammatory agent into hydrogels that biodegrade and adhere to the tissues to which the anti-arrhythmic drugs are to be delivered. The hydrogels may be formed in vitro or in vivo. In a preferred embodiment, the drugs are effective to lengthen atrial effective refractory period and minimize the inflammatory response. A particularly preferred drug is amiodarone and dexamethasone.

    摘要翻译： 已经开发了从应用于心脏或其血管的组织上或聚合在心脏或其血管的组织上的选择性抗心律失常药物的简单，可靠的应用和局部控制释放的方法，特别是与心脏旁路或其它心脏手术相结合的方法。 抗心律失常药物与抗炎剂一起掺入水凝胶中，生物降解并粘附到要递送抗心律失常药物的组织上。 水凝胶可以在体外或体内形成。 在优选的实施方案中，药物有效延长心房有效的不应期，并使炎症反应最小化。 特别优选的药物是胺碘酮和地塞米松。