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公开(公告)号：US20100009382A1
公开(公告)日：2010-01-14
申请号：US12556831
申请日：2009-09-10
申请人： Arul Chinnaiyan , David Beer , Guoan Chen , Xiaoju Wang
发明人： Arul Chinnaiyan , David Beer , Guoan Chen , Xiaoju Wang
IPC分类号： G01N33/53
CPC分类号： C12N15/1037 , C07K14/4748 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/57415 , G01N33/57423 , G01N33/57434 , G01N33/6845
摘要： The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ubiquilin 1 markers for cancer.
摘要翻译： 本发明涉及用于癌症诊断，研究和治疗的组合物和方法，包括但不限于癌症标志物。 特别地，本发明涉及用于癌症的泛素标记1。
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公开(公告)号：US08617547B2
公开(公告)日：2013-12-31
申请号：US12556831
申请日：2009-09-10
申请人： Arul Chinnaiyan , David Beer , Guoan Chen , Xiaoju Wang
发明人： Arul Chinnaiyan , David Beer , Guoan Chen , Xiaoju Wang
IPC分类号： A61K39/395
CPC分类号： C12N15/1037 , C07K14/4748 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/57415 , G01N33/57423 , G01N33/57434 , G01N33/6845
摘要： The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ubiquilin 1 markers for cancer.
摘要翻译： 本发明涉及用于癌症诊断，研究和治疗的组合物和方法，包括但不限于癌症标志物。 特别地，本发明涉及用于癌症的泛素标记1。
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公开(公告)号：US07597890B2
公开(公告)日：2009-10-06
申请号：US11715642
申请日：2007-03-08
申请人： Arul Chinnaiyan , David Beer , Guoan Chen , Xiaoju Wang
发明人： Arul Chinnaiyan , David Beer , Guoan Chen , Xiaoju Wang
IPC分类号： A61K39/395
CPC分类号： C12N15/1037 , C07K14/4748 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/57415 , G01N33/57423 , G01N33/57434 , G01N33/6845
摘要： The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ubiquilin 1 markers for cancer.
摘要翻译： 本发明涉及用于癌症诊断，研究和治疗的组合物和方法，包括但不限于癌症标志物。 特别地，本发明涉及用于癌症的泛素标记1。
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公开(公告)号：US20080044839A1
公开(公告)日：2008-02-21
申请号：US11715642
申请日：2007-03-08
申请人： Arul Chinnaiyan , David Beer , Guoan Chen , Xiaoju Wang
发明人： Arul Chinnaiyan , David Beer , Guoan Chen , Xiaoju Wang
IPC分类号： G01N33/53
CPC分类号： C12N15/1037 , C07K14/4748 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/57415 , G01N33/57423 , G01N33/57434 , G01N33/6845
摘要： The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ubiquilin 1 markers for cancer.
摘要翻译： 本发明涉及用于癌症诊断，研究和治疗的组合物和方法，包括但不限于癌症标志物。 特别地，本发明涉及用于癌症的泛素标记1。
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公开(公告)号：US20120295803A1
公开(公告)日：2012-11-22
申请号：US13473059
申请日：2012-05-16
申请人： David Beer , Jeremy Taylor , Guoan Chen , Sinae Kim
发明人： David Beer , Jeremy Taylor , Guoan Chen , Sinae Kim
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57423 , G01N2800/52
摘要： The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to cancer markers as diagnostic markers and clinical targets for lung cancer.
摘要翻译： 本公开涉及用于癌症诊断，研究和治疗的组合物和方法，包括但不限于癌症标志物。 特别地，本公开涉及癌症标志物作为肺癌的诊断标志物和临床靶标。
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公开(公告)号：US20100330587A1
公开(公告)日：2010-12-30
申请号：US12813070
申请日：2010-06-10
申请人： Samir M. Hanash , David Misek , Robert Hinderer , David Beer , Franck Brichory
发明人： Samir M. Hanash , David Misek , Robert Hinderer , David Beer , Franck Brichory
IPC分类号： G01N33/53
CPC分类号： G01N33/57488 , A61K39/0011 , G01N33/57423 , G01N33/57484 , G01N2333/4718 , G01N2800/52
摘要： The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a subject by means of detecting increased expression levels of annexin proteins in biological samples of the subject. The method of the invention can also be used to identify subjects at risk for developing cancer. The method of the invention involves the use of subject derived biological samples to determine the occurrence and level of expression of annexin proteins or expression of annexin derived peptides or antigens, and/or the occurrence and level of circulating autoantibodies to specific annexin protein antigens. The present invention further provides for kits for carrying out the above described screening methods. Such kits can be used to screen subjects for increased levels of annexin proteins, or for the detection of autoantibodies to annexin proteins, as a diagnostic, predictive or prognostic indicator of cancer.
摘要翻译： 本发明涉及通过检测来自受试者的血清中特异性膜联蛋白抗原的血清自身抗体的存在而在受试者中诊断，预后或易感性的筛选方法。 本发明还提供了通过检测受试者生物样品中膜联蛋白的增加的表达水平来检测受试者中癌症的诊断和预后的筛选方法。 本发明的方法还可以用于鉴定患有癌症风险的受试者。 本发明的方法涉及使用受试者衍生的生物样品来确定膜联蛋白的表达的发生和水平或膜联蛋白衍生的肽或抗原的表达，和/或对特定的膜联蛋白抗原的循环自身抗体的发生和水平。 本发明还提供了用于实施上述筛选方法的试剂盒。 这样的试剂盒可用于筛选受试者增加的膜联蛋白水平，或用于检测对膜联蛋白的自身抗体，作为癌症的诊断性，预测性或预后指标。
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公开(公告)号：US20060275845A1
公开(公告)日：2006-12-07
申请号：US11425439
申请日：2006-06-21
申请人： Samir HANASH , David Misek , Robert Hinderer , David Beer , Franck Brichory
发明人： Samir HANASH , David Misek , Robert Hinderer , David Beer , Franck Brichory
IPC分类号： G01N33/574
CPC分类号： G01N33/57488 , A61K39/0011 , G01N33/57423 , G01N33/57484 , G01N2333/4718 , G01N2800/52
摘要： The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a subject by means of detecting increased expression levels of annexin proteins in biological samples of the subject. The method of the invention can also be used to identify subjects at risk for developing cancer. The method of the invention involves the use of subject derived biological samples to determine the occurrence and level of express on of annexin proteins or expression of annexin derived peptides or antigens, and/or the occurrence and level of circulating autoantibodies to specific annexin protein antigens. The present invention further provides for kits for carrying out the above described screening methods. Such kits can be used to screen subjects for increased levels of annexin proteins, or for the detection of autoantibodies to annexin proteins, as a diagnostic, predictive or prognostic indicator of cancer.
摘要翻译： 本发明涉及通过检测来自受试者的血清中特异性膜联蛋白抗原的血清自身抗体的存在而在受试者中诊断，预后或易感性的筛选方法。 本发明还提供了通过检测受试者生物样品中膜联蛋白的增加的表达水平来检测受试者中癌症的诊断和预后的筛选方法。 本发明的方法还可以用于鉴定患有癌症风险的受试者。 本发明的方法涉及使用受试者衍生的生物样品来确定膜联蛋白的表达或膜联蛋白衍生的肽或抗原的表达的发生和水平，和/或特定膜联蛋白抗原的循环自身抗体的发生和水平。 本发明还提供了用于实施上述筛选方法的试剂盒。 这样的试剂盒可用于筛选受试者增加的膜联蛋白水平，或用于检测对膜联蛋白的自身抗体，作为癌症的诊断性，预测性或预后指标。
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公开(公告)号：US07955602B2
公开(公告)日：2011-06-07
申请号：US12813070
申请日：2010-06-10
申请人： Samir M. Hanash , David Misek , Robert Hinderer , David Beer , Frank Brichory
发明人： Samir M. Hanash , David Misek , Robert Hinderer , David Beer , Frank Brichory
IPC分类号： A61K49/00 , G01N33/574 , G01N33/48 , C12Q1/66
CPC分类号： G01N33/57488 , A61K39/0011 , G01N33/57423 , G01N33/57484 , G01N2333/4718 , G01N2800/52
摘要： The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a subject by means of detecting increased expression levels of annexin proteins in biological samples of the subject. The method of the invention can also be used to identify subjects at risk for developing cancer. The method of the invention involves the use of subject derived biological samples to determine the occurrence and level of expression of annexin proteins or expression of annexin derived peptides or antigens, and/or the occurrence and level of circulating autoantibodies to specific annexin protein antigens. The present invention further provides for kits for carrying out the above described screening methods. Such kits can be used to screen subjects for increased levels of annexin proteins, or for the detection of autoantibodies to annexin proteins, as a diagnostic, predictive or prognostic indicator of cancer.
摘要翻译： 本发明涉及通过检测来自受试者的血清中特异性膜联蛋白抗原的血清自身抗体的存在而在受试者中诊断，预后或易感性的筛选方法。 本发明还提供了通过检测受试者的生物样品中膜联蛋白的增加的表达水平来检测受试者中癌症的诊断和预后的筛选方法。 本发明的方法还可以用于鉴定患有癌症风险的受试者。 本发明的方法涉及使用受试者衍生的生物样品来确定膜联蛋白的表达的发生和水平或膜联蛋白衍生的肽或抗原的表达，和/或对特定的膜联蛋白抗原的循环自身抗体的发生和水平。 本发明还提供了用于实施上述筛选方法的试剂盒。 这样的试剂盒可用于筛选受试者增加的膜联蛋白水平，或用于检测对膜联蛋白的自身抗体，作为癌症的诊断性，预测性或预后指标。
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公开(公告)号：US20070148713A1
公开(公告)日：2007-06-28
申请号：US11549050
申请日：2006-10-12
申请人： Samir Hanash , David Beer , Rork Kuick , Robert Hinderer
发明人： Samir Hanash , David Beer , Rork Kuick , Robert Hinderer
IPC分类号： G01N33/574
CPC分类号： G01N33/57446 , G01N33/57407
摘要： Computerized analysis of 2-D gels, both carrier ampholyte (CA) and immobilized pH gradient (IPG) based, of the proteins in tissue from esophageal tumors, reveals proteins which are different in tumor and control tissue.
摘要翻译： 来自食管肿瘤组织中蛋白质的载体两性电泳（CA）和固定化pH梯度（IPG）的2-D凝胶的计算机化分析揭示了在肿瘤和对照组织中不同的蛋白质。
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公开(公告)号：US20070037227A1
公开(公告)日：2007-02-15
申请号：US11425528
申请日：2006-06-21
申请人： Samir Hanash , David Misek , Robert Hinderer , David Beer , Franck Brichory
发明人： Samir Hanash , David Misek , Robert Hinderer , David Beer , Franck Brichory
IPC分类号： G01N33/574
CPC分类号： G01N33/57488 , A61K39/0011 , G01N33/57423 , G01N33/57484 , G01N2333/4718 , G01N2800/52
摘要： The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a subject by means of detecting increased expression levels of annexin proteins in biological samples of the subject. The method of the invention can also be used to identify subjects at risk for developing cancer. The method of the invention involves the use of subject derived biological samples to determine the occurrence and level of expression of annexin proteins or expression of annexin derived peptides or antigens, and/or the occurrence and level of circulating autoantibodies to specific annexin protein antigens. The present invention further provides for kits for carrying out the above described screening methods. Such kits can be used to screen subjects for increased levels of annexin proteins, or for the detection of autoantibodies to annexin proteins, as a diagnostic, predictive or prognostic indicator of cancer.
摘要翻译： 本发明涉及通过检测来自受试者的血清中特异性膜联蛋白抗原的血清自身抗体的存在而在受试者中诊断，预后或易感性的筛选方法。 本发明还提供了通过检测受试者生物样品中膜联蛋白的增加的表达水平来检测受试者中癌症的诊断和预后的筛选方法。 本发明的方法还可以用于鉴定患有癌症风险的受试者。 本发明的方法涉及使用受试者衍生的生物样品来确定膜联蛋白的表达的发生和水平或膜联蛋白衍生的肽或抗原的表达，和/或对特定的膜联蛋白抗原的循环自身抗体的发生和水平。 本发明还提供了用于实施上述筛选方法的试剂盒。 这样的试剂盒可用于筛选受试者增加的膜联蛋白水平，或用于检测对膜联蛋白的自身抗体，作为癌症的诊断性，预测性或预后指标。
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