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    ANNEXIN PROTEINS AND AUTOANTIBODIES AS SERUM MARKERS FOR CANCER
    1.
    发明申请
    ANNEXIN PROTEINS AND AUTOANTIBODIES AS SERUM MARKERS FOR CANCER 失效
    作为癌症血清标记的新生蛋白和自身抗体

    公开(公告)号：US20070037227A1

    公开(公告)日：2007-02-15

    申请号：US11425528

    申请日：2006-06-21

    申请人： Samir Hanash ,  David Misek ,  Robert Hinderer ,  David Beer ,  Franck Brichory

    发明人： Samir Hanash ,  David Misek ,  Robert Hinderer ,  David Beer ,  Franck Brichory

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57488 ,  A61K39/0011 ,  G01N33/57423 ,  G01N33/57484 ,  G01N2333/4718 ,  G01N2800/52

    摘要： The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a subject by means of detecting increased expression levels of annexin proteins in biological samples of the subject. The method of the invention can also be used to identify subjects at risk for developing cancer. The method of the invention involves the use of subject derived biological samples to determine the occurrence and level of expression of annexin proteins or expression of annexin derived peptides or antigens, and/or the occurrence and level of circulating autoantibodies to specific annexin protein antigens. The present invention further provides for kits for carrying out the above described screening methods. Such kits can be used to screen subjects for increased levels of annexin proteins, or for the detection of autoantibodies to annexin proteins, as a diagnostic, predictive or prognostic indicator of cancer.

    摘要翻译： 本发明涉及通过检测来自受试者的血清中特异性膜联蛋白抗原的血清自身抗体的存在而在受试者中诊断，预后或易感性的筛选方法。 本发明还提供了通过检测受试者生物样品中膜联蛋白的增加的表达水平来检测受试者中癌症的诊断和预后的筛选方法。 本发明的方法还可以用于鉴定患有癌症风险的受试者。 本发明的方法涉及使用受试者衍生的生物样品来确定膜联蛋白的表达的发生和水平或膜联蛋白衍生的肽或抗原的表达，和/或对特定的膜联蛋白抗原的循环自身抗体的发生和水平。 本发明还提供了用于实施上述筛选方法的试剂盒。 这样的试剂盒可用于筛选受试者增加的膜联蛋白水平，或用于检测对膜联蛋白的自身抗体，作为癌症的诊断性，预测性或预后指标。

    Expression profile of pancreatic cancer
    5.
    发明申请
    Expression profile of pancreatic cancer 审中-公开
    胰腺癌的表达谱

    公开(公告)号：US20050009067A1

    公开(公告)日：2005-01-13

    申请号：US10848259

    申请日：2004-05-18

    申请人： Craig Logsdon ,  Samir Hanash ,  Diane Simeone

    发明人： Craig Logsdon ,  Samir Hanash ,  Diane Simeone

    IPC分类号： A61B20060101 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  G01N33/567 ,  G01N33/574

    CPC分类号： G01N33/57438 ,  G01N33/507 ,  G01N33/5082

    摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with pancreatic cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of pancreatic cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.

    摘要翻译： 本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了与胰腺癌相关的基因表达谱。 使用本发明的方法鉴定为癌症标志物的基因可用于胰腺癌的诊断和表征。 此外，这些基因为癌症药物筛选和治疗应用提供了靶标。