公开(公告)号：US20160296501A1

公开(公告)日：2016-10-13

申请号：US15184800

申请日：2016-06-16

Applicant: Asana Biosciences, LLC

Inventor： Scott K. Thompson ,  Aranapakam Venkatesan ,  Tony Priestley ,  Mrinal Kundu ,  Ashis Saha

IPC: A61K31/437 ,  A61K31/497 ,  A61K31/496 ,  A61K31/506 ,  A61K31/444 ,  A61K31/4545

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  C07D471/22

Abstract: The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.

Abstract translation: 本申请提供了用于制备和使用这些化合物的新型化合物和方法。 在一个实施方案中，化合物具有式（I）的结构，其中R 1 -R 4在本文中定义。 在另一个实施方案中，这些化合物可用于调节P2X3或P2X2 / 3受体中的一种或两种的方法。 在另一个实施方案中，这些化合物可用于通过向患者施用一种或多种化合物来治疗患者的疼痛。

公开(公告)号：US20240391925A1

公开(公告)日：2024-11-28

申请号：US18795061

申请日：2024-08-05

Applicant: Asana BioSciences, LLC

Inventor： Scott K. Thompson ,  Tony Priestley ,  Mrinalkanti Kundu ,  Ashis Saha ,  Suvadeep Nath

IPC: C07D487/04 ,  C07D519/00

Abstract: The present disclosure provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R7 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.

公开(公告)号：US11685736B2

公开(公告)日：2023-06-27

申请号：US16704264

申请日：2019-12-05

Applicant: Asana Biosciences, LLC

Inventor： Scott K. Thompson ,  Aranapakam Venkatesan ,  Tony Priestley ,  Mrinal Kundu ,  Ashis Saha

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  C07D471/22

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  C07D471/22

Abstract: The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient.

公开(公告)号：US10590127B2

公开(公告)日：2020-03-17

申请号：US15876810

申请日：2018-01-22

Applicant: Asana Biosciences, LLC

Inventor： Scott K. Thompson ,  Aranapakam Venkatesan ,  Tony Priestley ,  Mrinal Kundu ,  Ashis Saha

IPC: C07D471/04 ,  A61K31/506 ,  A61K31/496 ,  A61K31/444 ,  A61K31/437 ,  C07D471/22 ,  A61K31/4545 ,  A61K31/497

Abstract: The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.

公开(公告)号：US10544145B2

公开(公告)日：2020-01-28

申请号：US16392889

申请日：2019-04-24

Applicant: Asana Biosciences, LLC

Inventor： Scott K. Thompson ,  Aranapakam Venkatesan ,  Tony Priestley ,  Mrinal Kundu ,  Ashis Saha

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  C07D471/22

Abstract: The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient.

公开(公告)号：US10316039B2

公开(公告)日：2019-06-11

申请号：US15906712

申请日：2018-02-27

Applicant: Asana Biosciences, LLC

Inventor： Scott K. Thompson ,  Aranapakam Venkatesan ,  Tony Priestley ,  Mrinal Kundu ,  Ashis Saha

IPC: C07D471/04 ,  C07D471/22 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506

Abstract: The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient.

公开(公告)号：US20180141945A1

公开(公告)日：2018-05-24

申请号：US15876810

申请日：2018-01-22

Applicant: Asana Biosciences, LLC

Inventor： Scott K. Thompson ,  Aranapakam Venkatesan ,  Tony Priestley ,  Mrinal Kundu ,  Ashis Saha

IPC: C07D471/04 ,  A61K31/506 ,  A61K31/497 ,  A61K31/496 ,  A61K31/444 ,  A61K31/437 ,  C07D471/22 ,  A61K31/4545

Abstract: The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.

公开(公告)号：US20150290182A1

公开(公告)日：2015-10-15

申请号：US14727024

申请日：2015-06-01

Applicant: ASANA BIOSCIENCES, LLC

Inventor： Sandeep Gupta ,  Tony Priestley ,  Nicholas James Laping

IPC: A61K31/452 ,  A61K31/40 ,  A61K31/4545 ,  A61K31/167 ,  A61K31/454 ,  A61K31/5386 ,  A61K31/453 ,  A61K45/06 ,  A61K31/506

CPC classification number: A61K31/452 ,  A61K31/015 ,  A61K31/167 ,  A61K31/40 ,  A61K31/435 ,  A61K31/438 ,  A61K31/4425 ,  A61K31/445 ,  A61K31/453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5386 ,  A61K45/06 ,  C07D207/09 ,  C07D211/26 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D471/10 ,  C07D498/10 ,  A61K2300/00

Abstract: The present application provides methods of using the aminoindane compounds of formula (I) or (II) in treating an overactive bladder or interstitial cystitis by administering one or more of the compounds to a patient.

Abstract translation: 本申请提供了通过向患者施用一种或多种化合物来使用式（I）或（II）的氨基茚满化合物治疗膀胱过度活动或间质性膀胱炎的方法。

公开(公告)号：US09044482B2

公开(公告)日：2015-06-02

申请号：US13967389

申请日：2013-08-15

Applicant: Asana Biosciences, LLC

Inventor： Sandeep Gupta ,  Tony Priestley ,  Nicholas James Laping

IPC: A61K31/335 ,  A61K31/5386 ,  A61K31/40 ,  A61K31/435 ,  A61K31/452 ,  A61K31/453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  C07D207/09 ,  C07D211/26 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D471/10 ,  C07D498/10 ,  A61K45/06 ,  A61K31/015 ,  A61K31/438 ,  A61K31/4425 ,  A61K31/445

CPC classification number: A61K31/452 ,  A61K31/015 ,  A61K31/167 ,  A61K31/40 ,  A61K31/435 ,  A61K31/438 ,  A61K31/4425 ,  A61K31/445 ,  A61K31/453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5386 ,  A61K45/06 ,  C07D207/09 ,  C07D211/26 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D471/10 ,  C07D498/10 ,  A61K2300/00

Abstract: The present application provides methods of using the aminoindane compounds of formula (I) or (II) in treating an overactive bladder or interstitial cystitis by administering one or more of the compounds to a patient.

Abstract translation: 本申请提供了通过向患者施用一种或多种化合物来使用式（I）或（II）的氨基茚满化合物治疗膀胱过度活动或间质性膀胱炎的方法。

公开(公告)号：US09944637B2

公开(公告)日：2018-04-17

申请号：US15105526

申请日：2014-12-16

Applicant: Asana Biosciences, LLC

Inventor： Scott K. Thompson ,  Aranapakam Venkatesan ,  Tony Priestley ,  Mrinal Kundu ,  Ashis Saha

IPC: C07D471/04 ,  C07D471/22 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  C07D471/22

Abstract: The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient.