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1.发明授权公开(公告)号：US08476285B2
公开(公告)日：2013-07-02
申请号：US12494917
申请日：2009-06-30
申请人： Ashok C. Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
发明人： Ashok C. Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
IPC分类号： A61K31/52 , C07D473/34 , A61P35/00
CPC分类号： A61K31/52 , A61K31/522 , C07D473/34
摘要： The invention relates to compounds of Formulae I-III: and therapeutic uses thereof, wherein A is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carbocyclic group; B is chosen from a substituted or unsubstituted piperidine, homopiperidine, piperazine, pyrrolidine or azetidine group; R1 is chosen from hydro, alkyl, aryl, heteroaryl, amino, or halo; and L1, L2, are as defined herein.
摘要翻译： 本发明涉及式I-III的化合物及其治疗用途，其中A选自取代或未取代的芳基，杂芳基，杂环或碳环基团; B选自取代或未取代的哌啶，高哌啶，哌嗪，吡咯烷或氮杂环丁烷基; R 1选自氢，烷基，芳基，杂芳基，氨基或卤素; 和L1，L2如本文所定义。
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公开(公告)号：US20100016586A1
公开(公告)日：2010-01-21
申请号：US12494917
申请日：2009-06-30
申请人： ASHOK C. BAJJI , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
发明人： ASHOK C. BAJJI , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
IPC分类号： C07D413/14 , C07D473/34
CPC分类号： A61K31/52 , A61K31/522 , C07D473/34
摘要： The invention relates to compounds of Formulae I-III and their therapeutic uses.
摘要翻译： 本发明涉及式I-III的化合物及其治疗用途。
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公开(公告)号：US07595401B2
公开(公告)日：2009-09-29
申请号：US11748362
申请日：2007-05-14
申请人： Ashok C. Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
发明人： Ashok C. Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
IPC分类号： C07D473/34 , A61K31/52 , A61P35/00
CPC分类号： A61K31/52 , A61K31/522 , C07D473/34
摘要： The invention relates to compounds of Formula I and their therapeutic uses, wherein substituent A is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carboxylic group, B is chosen from a substituted or unsubstituted piperidine, homopiperidine, piperazine, pyrrolidine or azetidine group, R1 is chosen from hydro, alkyl, aryl, heteroaryl amino and halo, and L1 and L2 are as defined in the specification.
摘要翻译： 本发明涉及式I化合物及其治疗用途，其中取代基A选自取代或未取代的芳基，杂芳基，杂环或羧基，B选自取代或未取代的哌啶，高哌啶，哌嗪，吡咯烷或氮杂环丁烷 基团，R 1选自氢，烷基，芳基，杂芳基氨基和卤素，且L1和L2如说明书中所定义。
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公开(公告)号：US20070299258A1
公开(公告)日：2007-12-27
申请号：US11748362
申请日：2007-05-14
申请人： Ashok Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark Anderson , Daniel Wettstein , Mark Shenderovich , John Vanecko
发明人： Ashok Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark Anderson , Daniel Wettstein , Mark Shenderovich , John Vanecko
IPC分类号： C07D473/00 , C07D413/06
CPC分类号： A61K31/52 , A61K31/522 , C07D473/34
摘要： The invention relates to compounds of Formulae I-III and their therapeutic uses.
摘要翻译： 本发明涉及式I-III的化合物及其治疗用途。
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5.发明申请公开(公告)号：US20100292255A1
公开(公告)日：2010-11-18
申请号：US12780828
申请日：2010-05-14
申请人： Ashok C. Bajji , Se-Ho Kim , Rajendra Tangallapally , Benjamin J. Markovitz , Richard Trovato , Mark B. Anderson , Daniel A. Wettstein , Mark D. Shenderovich
发明人： Ashok C. Bajji , Se-Ho Kim , Rajendra Tangallapally , Benjamin J. Markovitz , Richard Trovato , Mark B. Anderson , Daniel A. Wettstein , Mark D. Shenderovich
IPC分类号： A61K31/52 , C07D473/36 , A61P35/00
CPC分类号： C07D473/34
摘要： The invention provides novel therapeutic compounds, pharmaceutical compositions comprising these compounds, and methods for using these compounds and compositions to treat diseases and disorders, such as cancer.
摘要翻译： 本发明提供新颖的治疗化合物，包含这些化合物的药物组合物，以及使用这些化合物和组合物治疗疾病和病症如癌症的方法。
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公开(公告)号：US08017780B1
公开(公告)日：2011-09-13
申请号：US12577042
申请日：2009-10-09
申请人： Ashok Bajji , Se-Ho Kim , Rajendra Tangallapally
发明人： Ashok Bajji , Se-Ho Kim , Rajendra Tangallapally
IPC分类号： C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： The invention provides novel therapeutic compounds, pharmaceutical compositions comprising these compounds, and methods for using these compounds and compositions to treat diseases and disorders such as cancer.
摘要翻译： 本发明提供了新的治疗化合物，包含这些化合物的药物组合物，以及使用这些化合物和组合物治疗诸如癌症的疾病和病症的方法。
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公开(公告)号：US20050222408A1
公开(公告)日：2005-10-06
申请号：US11044420
申请日：2005-01-27
IPC分类号： A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/433 , C07D413/02 , C07D417/02
CPC分类号： C07D405/06 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Compounds having the general structure: wherein A is selected from the group consisting of oxygen, sulfur, and NR15, and R15 is selected from the group consisting of H, alkyl, aryl, substituted alkyl, and substituted aryl; B,D, and E are each independently selected from the group consisting of CH, nitrogen, sulfur and oxygen; R1 is selected from the group consisting of nitro, halo, alkyl ester, arylsulfanyl, arylsulfinyl, arylsulfonyl and sulfonic acid; t is an integer from 1 to 3; and X is a substituted amide, and methods of using the novel compounds for treating infections caused by microorganisms, including Mycobacterium tuberculosis.
摘要翻译： 具有一般结构的化合物：其中A选自氧，硫和NR 15，并且R 15选自H，烷基 ，芳基，取代的烷基和取代的芳基; B，D和E各自独立地选自CH，氮，硫和氧; R 1选自硝基，卤代，烷基酯，芳基硫烷基，芳基亚磺酰基，芳基磺酰基和磺酸; t为1〜3的整数; 和X是取代的酰胺，以及使用该新化合物治疗包括结核分枝杆菌在内的微生物引起的感染的方法。
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公开(公告)号：US20050026968A1
公开(公告)日：2005-02-03
申请号：US10890750
申请日：2004-07-14
IPC分类号： A61K31/345 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/433 , A61K31/4525 , A61K31/496 , C07D20060101 , C07D307/70 , C07D401/12 , C07D403/12 , C07D413/02 , C07D417/02
CPC分类号： C07D405/12 , C07D405/06 , C07D413/12 , C07D417/12
摘要： Compounds having the general structure: wherein A is selected from the group consisting of oxygen, sulfur, and NR15, and R15 is selected from the group consisting of H, alkyl, aryl, substituted alkyl, and substituted aryl; B,D, and E are each independently selected from the group consisting of CH, nitrogen, sulfur and oxygen; R1 is selected from the group consisting of nitro, halo, alkyl ester, phenylsulfanyl, phenylsulfinyl, phenylsulfonyl and sulfonic acid; t is an integer from 1 to 3; and X is a substituted amide and methods of using the novel compounds for treating infections caused microorganisms, including Mycobacterium tuberculosis.
摘要翻译： 具有一般结构的化合物：其中A选自氧，硫和NR 15，R 15选自H，烷基，芳基，取代的烷基和取代的芳基; B，D和E各自独立地选自CH，氮，硫和氧; R1选自硝基，卤代，烷基酯，苯基硫烷基，苯基亚磺酰基，苯基磺酰基和磺酸; t为1〜3的整数; X是取代酰胺，以及使用该新化合物治疗感染引起的微生物，包括结核分枝杆菌的方法。
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