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1.发明申请公开(公告)号：US20100292255A1
公开(公告)日：2010-11-18
申请号：US12780828
申请日：2010-05-14
申请人： Ashok C. Bajji , Se-Ho Kim , Rajendra Tangallapally , Benjamin J. Markovitz , Richard Trovato , Mark B. Anderson , Daniel A. Wettstein , Mark D. Shenderovich
发明人： Ashok C. Bajji , Se-Ho Kim , Rajendra Tangallapally , Benjamin J. Markovitz , Richard Trovato , Mark B. Anderson , Daniel A. Wettstein , Mark D. Shenderovich
IPC分类号： A61K31/52 , C07D473/36 , A61P35/00
CPC分类号： C07D473/34
摘要： The invention provides novel therapeutic compounds, pharmaceutical compositions comprising these compounds, and methods for using these compounds and compositions to treat diseases and disorders, such as cancer.
摘要翻译： 本发明提供新颖的治疗化合物，包含这些化合物的药物组合物，以及使用这些化合物和组合物治疗疾病和病症如癌症的方法。
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2.发明授权公开(公告)号：US08476285B2
公开(公告)日：2013-07-02
申请号：US12494917
申请日：2009-06-30
申请人： Ashok C. Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
发明人： Ashok C. Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
IPC分类号： A61K31/52 , C07D473/34 , A61P35/00
CPC分类号： A61K31/52 , A61K31/522 , C07D473/34
摘要： The invention relates to compounds of Formulae I-III: and therapeutic uses thereof, wherein A is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carbocyclic group; B is chosen from a substituted or unsubstituted piperidine, homopiperidine, piperazine, pyrrolidine or azetidine group; R1 is chosen from hydro, alkyl, aryl, heteroaryl, amino, or halo; and L1, L2, are as defined herein.
摘要翻译： 本发明涉及式I-III的化合物及其治疗用途，其中A选自取代或未取代的芳基，杂芳基，杂环或碳环基团; B选自取代或未取代的哌啶，高哌啶，哌嗪，吡咯烷或氮杂环丁烷基; R 1选自氢，烷基，芳基，杂芳基，氨基或卤素; 和L1，L2如本文所定义。
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公开(公告)号：US20100016586A1
公开(公告)日：2010-01-21
申请号：US12494917
申请日：2009-06-30
申请人： ASHOK C. BAJJI , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
发明人： ASHOK C. BAJJI , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
IPC分类号： C07D413/14 , C07D473/34
CPC分类号： A61K31/52 , A61K31/522 , C07D473/34
摘要： The invention relates to compounds of Formulae I-III and their therapeutic uses.
摘要翻译： 本发明涉及式I-III的化合物及其治疗用途。
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公开(公告)号：US07595401B2
公开(公告)日：2009-09-29
申请号：US11748362
申请日：2007-05-14
申请人： Ashok C. Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
发明人： Ashok C. Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
IPC分类号： C07D473/34 , A61K31/52 , A61P35/00
CPC分类号： A61K31/52 , A61K31/522 , C07D473/34
摘要： The invention relates to compounds of Formula I and their therapeutic uses, wherein substituent A is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carboxylic group, B is chosen from a substituted or unsubstituted piperidine, homopiperidine, piperazine, pyrrolidine or azetidine group, R1 is chosen from hydro, alkyl, aryl, heteroaryl amino and halo, and L1 and L2 are as defined in the specification.
摘要翻译： 本发明涉及式I化合物及其治疗用途，其中取代基A选自取代或未取代的芳基，杂芳基，杂环或羧基，B选自取代或未取代的哌啶，高哌啶，哌嗪，吡咯烷或氮杂环丁烷 基团，R 1选自氢，烷基，芳基，杂芳基氨基和卤素，且L1和L2如说明书中所定义。
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公开(公告)号：US20070299258A1
公开(公告)日：2007-12-27
申请号：US11748362
申请日：2007-05-14
申请人： Ashok Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark Anderson , Daniel Wettstein , Mark Shenderovich , John Vanecko
发明人： Ashok Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark Anderson , Daniel Wettstein , Mark Shenderovich , John Vanecko
IPC分类号： C07D473/00 , C07D413/06
CPC分类号： A61K31/52 , A61K31/522 , C07D473/34
摘要： The invention relates to compounds of Formulae I-III and their therapeutic uses.
摘要翻译： 本发明涉及式I-III的化合物及其治疗用途。
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公开(公告)号：US06710088B2
公开(公告)日：2004-03-23
申请号：US10060959
申请日：2002-01-29
申请人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
发明人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
IPC分类号： A61K31135
CPC分类号： C07C255/58 , A61K31/137 , A61K31/36 , C07C211/29 , C07C211/30 , C07C217/58 , C07C217/62 , C07C255/54 , C07C2601/02 , C07D307/81 , C07D317/58
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.
摘要翻译： 本发明的特征在于能够调节一种或多种无机离子受体活性的化合物和使用这些化合物治疗疾病或病症的方法。 优选的化合物可以模拟或阻断细胞外钙对细胞表面钙受体的作用。
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公开(公告)号：US06342532B1
公开(公告)日：2002-01-29
申请号：US09415179
申请日：1999-10-06
申请人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
发明人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
IPC分类号： A61K31137
CPC分类号： C07C255/58 , A61K31/137 , A61K31/36 , C07C211/29 , C07C211/30 , C07C217/58 , C07C217/62 , C07C255/54 , C07C2601/02 , C07D307/81 , C07D317/58
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.
摘要翻译： 本发明的特征在于能够调节一种或多种无机离子受体活性的化合物和使用这些化合物治疗疾病或病症的方法。 优选的化合物可以模拟或阻断细胞外钙对细胞表面钙受体的作用。
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公开(公告)号：US07053104B2
公开(公告)日：2006-05-30
申请号：US10211523
申请日：2002-08-05
申请人： Bradford C. Van Wagenen , Scott T. Moe , Daryl L. Smith , Susan M. Sheehan , Irina Shcherbakova , Ruth Walton , Richard Trovato , Robert Barmore , Eric G. Delmar , Thomas M. Stormann
发明人： Bradford C. Van Wagenen , Scott T. Moe , Daryl L. Smith , Susan M. Sheehan , Irina Shcherbakova , Ruth Walton , Richard Trovato , Robert Barmore , Eric G. Delmar , Thomas M. Stormann
IPC分类号： A61K31/47 , C07D215/14
CPC分类号： C07D213/81 , C07D209/42 , C07D213/82 , C07D215/12 , C07D215/20 , C07D215/38 , C07D215/48 , C07D215/54 , C07D217/26 , C07D231/12 , C07D233/56 , C07D241/42 , C07D241/44 , C07D249/08 , C07D277/68 , C07D277/70 , C07D307/68 , C07D307/84 , C07D333/38 , C07D333/68 , C07D491/04
摘要： The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
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公开(公告)号：US20090155903A1
公开(公告)日：2009-06-18
申请号：US10593180
申请日：2005-03-21
IPC分类号： C12N5/06 , C07D209/12 , C07D401/04
CPC分类号： C07D209/18 , C07D209/42 , C07D403/06 , C07D405/06
摘要： The invention provides compounds, pharmaceutical compositions and methods for the therapeutic treatment and prevention of neurodegenerative disorder and other Aβ42-related diseases and disorders.
摘要翻译： 本发明提供了用于治疗和预防神经变性疾病和其它Aβ42相关疾病和病症的化合物，药物组合物和方法。
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公开(公告)号：US5981599A
公开(公告)日：1999-11-09
申请号：US846721
申请日：1997-04-30
申请人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
发明人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
IPC分类号： C07C211/58 , A61K31/00 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/36 , A61P3/00 , A61P3/14 , A61P5/00 , A61P5/16 , A61P9/00 , A61P9/12 , A61P19/00 , A61P19/10 , C07C211/29 , C07C211/30 , C07C217/58 , C07C217/62 , C07C217/92 , C07C255/54 , C07C255/58 , C07D307/81 , C07D317/58
CPC分类号： C07C255/58 , A61K31/137 , A61K31/36 , C07C211/29 , C07C211/30 , C07C217/58 , C07C217/62 , C07C255/54 , C07D307/81 , C07D317/58 , C07C2101/02
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.
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