公开(公告)号：US5951538A

公开(公告)日：1999-09-14

申请号：US908687

申请日：1997-08-07

申请人： Ashok V. Joshi ,  Giorgio di Palma ,  Truman Wold

发明人： Ashok V. Joshi ,  Giorgio di Palma ,  Truman Wold

IPC分类号： A61K9/22 ,  A61D7/00 ,  A61M13/00 ,  A61M31/00

CPC分类号： A61M31/002

摘要： A controlled delivery device for holding and administering a biologically active agent includes a housing having a first end portion, a second end portion, and a port associated with the housing. Enclosed within the housing is a displacing member, a chemical or electrochemical gas generating cell, activation and control circuitry. The electrochemical or chemical cell generates gas within the housing, forcing the displacing member against the beneficial agents contained within the housing and forcing the beneficial agents through an outlet port and into an animal's body cavity at a predetermined rate. An anchoring mechanism may be associated with the housing for securing the housing inside the body cavity of the animal being treated. Also disclosed are methods of delivering the beneficial agents into the animal's body cavity using the delivery device of the present invention.

摘要翻译： 用于保持和施用生物活性剂的受控递送装置包括具有第一端部分，第二端部部分和与壳体相关联的端口的壳体。 封闭在壳体内的是移动构件，化学或电化学气体发生单元，激活和控制电路。 电化学或化学电池在壳体内产生气体，迫使移位构件抵抗容纳在壳体内的有益剂，并以有利的作用力通过出口端口以预定的速率进入动物体腔。 锚固机构可以与壳体相关联，用于将壳体固定在被处理动物的体腔内。 还公开了使用本发明的递送装置将有益药物递送到动物体腔中的方法。

公开(公告)号：US5954268A

公开(公告)日：1999-09-21

申请号：US139446

申请日：1998-08-25

申请人： Ashok V. Joshi ,  John H. Gordon ,  Giorgio di Palma ,  John I. McEvoy ,  Truman Wold

发明人： Ashok V. Joshi ,  John H. Gordon ,  Giorgio di Palma ,  John I. McEvoy ,  Truman Wold

IPC分类号： A61L9/12 ,  A24F25/00

CPC分类号： A61L9/12

摘要： A fluid delivery apparatus includes a housing having an open end and an interior surface. The interior of the housing defines a cavity within the housing. The cavity, in combination with a piston-like member, defines a reservoir for containing a fluid (e.g. such as an aromatic or other solvent or a solvent in which has been dissolved an aromatic substance). The piston has a port, and fits in piston-like arrangement within a cylinder contained within the housing. The piston moves within the housing, and movement of the piston acts to displace fluid from the port upon contraction of the reservoir (e.g. when the annular piston is driven into the device). Preferably, a fluid tight membrane covers the housing's open end. The apparatus also preferably further includes a conduit to transport fluid from the housing of the reservoir. The conduit has, on a first end, an exterior circumference sized and shaped to interact with the port of the annular member. On the second end of the conduit is preferably associated a sponge, wick or equivalent fragrance dispenser.

摘要翻译： 流体输送装置包括具有开口端和内表面的壳体。 壳体的内部限定了壳体内的空腔。 空腔与活塞状构件组合，限定用于容纳流体（例如其中溶解有芳族物质的芳族或其它溶剂或溶剂）的储存器。 活塞具有一个端口，并且适合在容纳在壳体内的圆柱体内的活塞状布置。 活塞在壳体内移动，并且当储存器收缩时（例如当环形活塞被驱动到装置中时），活塞的运动用于使流体从端口移位。 优选地，流体密封膜覆盖壳体的开口端。 该装置还优选地还包括用于从储存器的壳体输送流体的导管。 导管在第一端具有尺寸和形状以与环形构件的端口相互作用的外圆周。 在导管的第二端优选地与海绵，芯或等效的香料分配器相关联。

公开(公告)号：US5785688A

公开(公告)日：1998-07-28

申请号：US646069

申请日：1996-05-07

申请人： Ashok V. Joshi ,  James O. Davis ,  Truman Wold ,  Giorgio di Palma

发明人： Ashok V. Joshi ,  James O. Davis ,  Truman Wold ,  Giorgio di Palma

IPC分类号： A61M5/142 ,  A61M5/145 ,  A61M35/00 ,  A61M37/00

CPC分类号： A61M5/14593 ,  A61M2005/14204 ,  A61M2005/14252 ,  A61M35/006 ,  A61M5/14244 ,  A61M5/14248

摘要： An apparatus (120) useful for, among other things, subcutaneous drug delivery includes a housing (124), a fluid reservoir (154) disposed within the housing for storing the fluid, a pump or pressurized chamber for pressurizing a driving gas and exerting a force on the fluid reservoir to expel the fluid reservoir's contents, and a needle (150) or absorbent pad fluidically communicating with the reservoir. The apparatus may further include a pump activation mechanism such as a button and an electrical circuit such that pushing the button activates a circuit and connects a battery (138) to a pump (126), and a pump control mechanism such as electrical circuitry to control the voltage gradient to a pump to control fluid delivery.

摘要翻译： 用于（其中包括）皮下药物递送的装置（120）包括壳体（124），设置在壳体内用于储存流体的流体储存器（154），用于对驱动气体加压并施加压力的泵 流体储存器上的力被排出流体储存器的内容物，以及与储存器流体连通的针（150）或吸收垫。 该设备还可以包括诸如按钮和电路的泵激活机构，使得按下按钮激活电路并将电池（138）连接到泵（126），以及诸如电路的泵控制机构来控制 泵的电压梯度来控制流体输送。

公开(公告)号：US5899381A

公开(公告)日：1999-05-04

申请号：US803009

申请日：1997-02-21

申请人： John H. Gordon ,  Ashok V. Joshi ,  Giorgio di Palma

发明人： John H. Gordon ,  Ashok V. Joshi ,  Giorgio di Palma

IPC分类号： A01M1/20 ,  A01M13/00 ,  A01M29/12 ,  A61L9/03 ,  A61L9/12 ,  A61L9/04

CPC分类号： A01M1/2077 ,  A01M29/12 ,  A61L9/03 ,  A61L9/12

摘要： An electrically controlled pump (20) for dispersing a volatile substance into a local environment includes an enclosure defining a volume, a moveable member (52) separating the enclosure into first (54) and second (56) chambers (the second chamber containing non-solid composition which includes a volatile substance), an electrochemical cell (48) for generating gas. The electrochemical cell is associated with the enclosure, and is in fluid communication with the first chamber. A port preferably communicates the second chamber with a medium for dispersing the volatile substance into the local environment. Also, a case (58) may encase the pump and hold it in an upright position with respect to a surface upon which the case is positioned.

摘要翻译： 一种用于将挥发性物质分散到局部环境中的电控泵（20）包括限定容积的外壳，将外壳分隔成第一（54）和第二腔室（56）的可移动构件（52） 包括挥发性物质的固体组合物），用于产生气体的电化学电池（48）。 电化学电池与外壳相关联，并且与第一腔室流体连通。 端口优选地将第二室与用于将挥发性物质分散到本地环境中的介质连通。 此外，壳体（58）可以包围泵并将其保持在相对于壳体定位的表面的直立位置。

公开(公告)号：US20120037658A1

公开(公告)日：2012-02-16

申请号：US13281288

申请日：2011-10-25

申请人： John Howard Gordon ,  Ashok V. Joshi ,  Truman Wold ,  Sai Bhavaraju

发明人： John Howard Gordon ,  Ashok V. Joshi ,  Truman Wold ,  Sai Bhavaraju

IPC分类号： B67D7/16

CPC分类号： A01M1/2044 ,  A61L9/12 ,  Y10T137/2931

摘要： A method for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The method features steady rate performance without refreshing the water chamber and low temperature sensitivity.

摘要翻译： 在本发明的一个实施例中公开了一种递送有益剂的方法，包括一个收水室。 提供水输送膜以与收集室连通。 提取室通过水输送膜接收水，使提取室膨胀。 包含有益剂的分配腔被构造成在膨胀提取室时收缩。 这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。 在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。 水输送膜具有排斥渗透到收集室的特征。 该方法具有稳定的速率性能，无需刷新水箱和低温灵敏度。

公开(公告)号：US08061280B2

公开(公告)日：2011-11-22

申请号：US12550050

申请日：2009-08-28

申请人： John Howard Gordon ,  Ashok V. Joshi ,  Truman Wold ,  Sai Bhavaraju

发明人： John Howard Gordon ,  Ashok V. Joshi ,  Truman Wold ,  Sai Bhavaraju

IPC分类号： A01C23/02

CPC分类号： A01M1/2044 ,  A61L9/12 ,  Y10T137/2931

摘要： An apparatus for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The apparatus features steady rate performance without refreshing the water chamber and low temperature sensitivity.

摘要翻译： 在本发明的一个实施例中公开了一种用于递送有益剂的装置，包括水收集室。 提供水输送膜以与收集室连通。 提取室通过水输送膜接收水，使提取室膨胀。 包含有益剂的分配腔被构造成在膨胀提取室时收缩。 这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。 在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。 水输送膜具有排斥渗透到收集室的特征。 该设备具有稳定的速率性能，无需刷新水室和低温灵敏度。

公开(公告)号：US07658156B2

公开(公告)日：2010-02-09

申请号：US12100982

申请日：2008-04-10

申请人： Truman Wold ,  Ashok V. Joshi ,  Sai Bhavaraju

发明人： Truman Wold ,  Ashok V. Joshi ,  Sai Bhavaraju

IPC分类号： A01C23/02

CPC分类号： A01G27/006 ,  A01G29/00

摘要： An apparatus for delivering a beneficial agent to a subterranean location is disclosed in one embodiment of the invention as including a water collection chamber having a substantially open end. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent such as fertilizer, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled from the subterranean delivery channel.

摘要翻译： 在本发明的一个实施例中公开了一种用于将有益剂递送到地下位置的装置，包括具有基本开口端的水收集室。 提供水输送膜以与收集室连通。 提取室通过水输送膜接收水，使提取室膨胀。 包含有益剂例如肥料的分配室被构造成在膨胀提取室时收缩。 这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。 在某些实施方案中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂从地下输送通道排出的速率。

公开(公告)号：US07149417B2

公开(公告)日：2006-12-12

申请号：US10708253

申请日：2004-02-19

申请人： Ashok V. Joshi ,  Truman Wold

发明人： Ashok V. Joshi ,  Truman Wold

IPC分类号： F24F6/00

CPC分类号： A01M1/2044 ,  A01M1/2033 ,  A01M1/2072 ,  A01M1/2077 ,  A61L9/02 ,  A61L9/03 ,  A61L9/04 ,  A61L9/12 ,  A61L9/122

摘要： The present invention is directed to a device for releasing a controlled amount of a volatile substance into an environment while isolating the non-released amount of such a substance from the environment. The device includes a housing having an interior region, a volatile substance cartridge associated with the housing, wherein the cartridge can be replaced, or, alternatively, refilled with a desired fluid. A mechanism is provided for releasing a pre-determined amount of fluid from the housing, which is activated, as desired, by a user of the device.

摘要翻译： 本发明涉及一种用于将受控量的挥发性物质释放到环境中，同时将这种物质的未释放量与环境隔离的装置。 该装置包括具有内部区域的壳体，与壳体相关联的挥发性物质盒，其中可以更换墨盒，或者替换地，用期望的流体重新填充墨盒。 提供了用于从外壳释放预定量的流体的机构，其根据需要由设备的使用者被激活。

公开(公告)号：US06327426B1

公开(公告)日：2001-12-04

申请号：US09696839

申请日：2000-10-26

申请人： Ashok V. Joshi ,  Truman Wold

发明人： Ashok V. Joshi ,  Truman Wold

IPC分类号： A01G1306

CPC分类号： A01M1/2077

摘要： An apparatus for delivering a beneficial agent to a surrounding area comprising a first electroactive electrode, a beneficial agent, a second electroactive electrode and an electrical associating member. The first electroactive electrode includes an outer surface, a portion of which is exposable to the surrounding area. The beneficial agent is dispersed within the first electroactive electrode. The second electroactive electrode is associated with the first electroactive electrode. The electrical associating member electrically associates the first electroactive electrode and the second electroactive electrode, to, facilitate corrosion of the exposable surface of the first electroactive electrode, upon exposure of same to the surrounding area, and, in turn the release of the beneficial agent.

摘要翻译： 一种用于将有益剂输送到包括第一电活性电极，有益试剂，第二电活性电极和电连接构件的周围区域的装置。 第一电活性电极包括外表面，其一部分可暴露于周围区域。 有益剂分散在第一电活性电极内。 第二电活性电极与第一电活性电极相关联。 电连接构件使第一电活性电极和第二电活性电极电连接，以便在暴露于周围区域时促进第一电活性电极的可暴露表面的腐蚀，从而促进有益剂的释放。

公开(公告)号：US20130026194A1

公开(公告)日：2013-01-31

申请号：US13323341

申请日：2011-12-12

申请人： Truman Wold ,  John Howard Gordon ,  Ashok V. Joshi

发明人： Truman Wold ,  John Howard Gordon ,  Ashok V. Joshi

IPC分类号： B65D83/76

CPC分类号： A61M5/14526 ,  A61L9/12 ,  A61L2209/132 ,  A61M5/14244 ,  A61M11/007 ,  A61M2005/14204 ,  A61M2005/14513 ,  A61M2205/3368 ,  A61M2205/8206 ,  A61M2205/8231 ,  B05B11/025 ,  B05B11/04 ,  B05B11/061

摘要： An on-demand fluid dispenser to dispense fluid in response to gas generation by a gas cell. The on-demand fluid dispenser includes an expandable gas chamber, a fluid chamber, and an on-demand gas cell. The expandable gas chamber includes a moveable plunger forming a wall of the expandable gas chamber. The moveable plunger also forms a wall of the fluid chamber. The on-demand gas cell is configured to generate the gas on demand. The on-demand gas cell is also configured to direct the gas to the expandable gas chamber to expand the expandable gas chamber. Expansion of the expandable gas chamber moves the moveable plunger to reduce a volume of the fluid chamber and to dispense an amount of fluid from the fluid chamber.

摘要翻译： 一种按需流体分配器，用于响应气体生成气体而分配流体。 按需流体分配器包括可膨胀气体室，流体室和按需气体室。 可膨胀气体室包括形成可膨胀气体室的壁的活动柱塞。 可移动柱塞还形成流体室的壁。 按需气体电池被配置成根据需要产生气体。 按需气体室还构造成将气体引导到可膨胀气体室以膨胀可膨胀气体室。 可膨胀气体室的膨胀使可移动的柱塞移动以减小流体室的体积并从流体室分配一定量的流体。