Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
    3.
    发明授权
    Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy 有权
    5-氨基乙酰丙酸的酯类作为光化学疗法中的光敏剂

    公开(公告)号:US07247655B2

    公开(公告)日:2007-07-24

    申请号:US10410636

    申请日:2003-04-09

    摘要: The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

    摘要翻译: 本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物,包括式(I)R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物(其中R 1可以表示任选被羟基,烷氧基,酰氧基,烷氧基羰基氧基, 氨基,芳基,氧代或氟基团,并且任选地被氧,氮,硫或磷原子间隔;并且R 2表示氢原子或基团R 1,并且两个R 2基团可以相同或不同),以及它们在诊断和 身体的外表面或内表面的紊乱或异常的光化学疗法,以及用于实施本发明的产品和试剂盒。

    Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy

    公开(公告)号:US06992107B1

    公开(公告)日:2006-01-31

    申请号:US09655570

    申请日:2000-09-06

    摘要: The present invention provides a compound of formula I; R22N—CH2COCH2—CH2CO—OR1  (I) wherein R1 represents (a) an optionally substituted branched C6-30 alkyl group, comprising a straight chain C4-29 alkyl group, branched by substitution with one or more C1-6 alkyl groups, wherein said site of substitution is at C2 or a higher C atom, (b) a non-heteroaromatic aryl substituted alkyl group, wherein said aryl group is substituted, or (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, wherein in (a) and (b) said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups, and said alkyl group is optionally interrupted or terminated by one or more —O—, NR3—, —S— or PR3— groups; R2, each of which may be the same or different, represents a hydrogen atom or a group R1, wherein R1 represents (a) an optionally substituted branched C5-30 alkyl group, comprising a straight chain C4-29 alkyl group, branched by substitution with one or more C1-6 alkyl groups, wherein said site of substitution is at C2 or a higher C atom, (b) a non-heteroaromatic aryl substituted alkyl group, wherein said aryl group is substituted, or (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, wherein in (a) and (b) said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups, and said alkyl group is optionally interrupted or terminated by one or more —O—, NR3—, —S— or PR3— groups; and R3 represents a hydrogen or C1-6 alkyl group, and salts thereof for use in photochemotherapy or diagnosis. Pharmaceutical compositions comprising said compound, methods of diagnosis or photochemotherapy using said compound and related compounds and compositions, and products and kits comprising said compounds are also provided.

    Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
    6.
    发明申请
    Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy 有权
    5-氨基乙酰丙酸的酯类作为光化学疗法中的光敏剂

    公开(公告)号:US20050031541A1

    公开(公告)日:2005-02-10

    申请号:US10818917

    申请日:2004-04-05

    摘要: The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

    摘要翻译: 本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物,包括式(I)R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物(其中R 1可以表示任选被羟基,烷氧基,酰氧基,烷氧基羰基氧基, 氨基,芳基,氧代或氟基团,并且任选地被氧,氮,硫或磷原子间隔;并且R 2表示氢原子或基团R 1,并且两个R 2基团可以相同或不同),以及它们在诊断和 身体的外表面或内表面的紊乱或异常的光化学疗法,以及用于实施本发明的产品和试剂盒。

    Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
    7.
    发明授权
    Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy 有权
    5-氨基乙酰丙酸的酯类作为光化学疗法中的光敏剂

    公开(公告)号:US07335684B2

    公开(公告)日:2008-02-26

    申请号:US11290275

    申请日:2005-11-29

    IPC分类号: A61K31/22 C07C229/00

    摘要: The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

    摘要翻译: 本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物,包括式(I)R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物(其中R 1可以表示任选被羟基,烷氧基,酰氧基,烷氧基羰基氧基, 氨基,芳基,氧代或氟基团,并且任选地被氧,氮,硫或磷原子间隔;并且R 2表示氢原子或基团R 1,并且两个R 2基团可以相同或不同),以及它们在诊断和 身体的外表面或内表面的紊乱或异常的光化学疗法,以及用于实施本发明的产品和试剂盒。

    Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
    10.
    发明授权
    Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy 失效
    5-氨基乙酰丙酸的酯类作为光化学疗法中的光敏剂

    公开(公告)号:US06492420B2

    公开(公告)日:2002-12-10

    申请号:US09471620

    申请日:1999-12-21

    IPC分类号: A61K3744

    摘要: The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

    摘要翻译: 本发明涉及作为5-氨基乙酰丙酸的酯或其药学上可接受的盐的化合物,包括式(I)R 22 N-CH 2 COCH 2 -CH 2 CO-OR 1的化合物(其中R 1可以表示任选被羟基,烷氧基,酰氧基,烷氧基羰基氧基, 氨基,芳基,氧代或氟基团,并且任选地被氧,氮,硫或磷原子间隔;并且R 2表示氢原子或基团R 1,并且两个R 2基团可以相同或不同),以及它们在诊断和 身体的外表面或内表面的紊乱或异常的光化学疗法,以及用于实施本发明的产品和试剂盒。