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11 条记录 (耗时 0.017 秒)

    FLUORESCENT PROTEIN
    1.
    发明申请
    FLUORESCENT PROTEIN 失效
    荧光蛋白

    公开(公告)号：US20080166799A1

    公开(公告)日：2008-07-10

    申请号：US11739133

    申请日：2007-04-24

    申请人： Atsushi MIYAWAKI ,  Satoshi KARASAWA

    发明人： Atsushi MIYAWAKI ,  Satoshi KARASAWA

    IPC分类号： C12N5/06 ,  C07H21/04 ,  C12N15/63

    CPC分类号： C07K14/37

    摘要： An object of the present invention is to provide a novel fluorescent protein derived from organisms other than Aequorea victoria. According to the present invention, there is provided a fluorescent protein derived from Fungia sp., which has the following properties: (1) the excitation maximum wavelength is 455 nm, and the fluorescence maximum wavelength is 488 nm; (2) the molar absorption coefficient at 455 nm is 38700 or 27700; (3) the quantum yield is 0.85 or 0.81; and (4) the pH sensitivity of the fluorescent property is stable at pH 5 to 9; and a fluorescent protein derived from Fungia sp., which has the following properties: (1) the excitation maximum wavelength is 548 nm, and the fluorescence maximum wavelength is 561 nm; (2) the molar absorption coefficient at 548 nm is 75900 or 51000; (3) the quantum yield is 0.44 or 0.50; and (4) the pH sensitivity of the fluorescent property is pKa

    摘要翻译： 本发明的目的是提供一种源自维他命A（Aequorea victoria）以外的生物体的新型荧光蛋白。 根据本发明，提供了一种衍生自真菌属的荧光蛋白，具有以下性质：（1）激发最大波长为455nm，荧光最大波长为488nm; （2）455nm处的摩尔吸光系数为38700或27700; （3）量子产率为0.85或0.81; 和（4）荧光性能的pH敏感性在pH5至9下是稳定的; 和一种来自真菌属的荧光蛋白，具有以下特性：（1）激发最大波长为548nm，荧光最大波长为561nm; （2）548nm处的摩尔吸光系数为75900或51000; （3）量子产率为0.44或0.50; 和（4）荧光性质的pH敏感度为pKa <5.0。

    FLUORESCENT PROTEIN
    3.
    发明申请
    FLUORESCENT PROTEIN 有权
    荧光蛋白

    公开(公告)号：US20110152502A1

    公开(公告)日：2011-06-23

    申请号：US13008610

    申请日：2011-01-18

    申请人： Atsushi MIYAWAKI ,  Ryoko ANDO ,  Hideaki MIZUNO ,  Satoshi KARASAWA

    发明人： Atsushi MIYAWAKI ,  Ryoko ANDO ,  Hideaki MIZUNO ,  Satoshi KARASAWA

    IPC分类号： C07K14/435 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21

    CPC分类号： C07K14/43595 ,  G03C1/731 ,  G03C1/733

    摘要： The object of the present invention is to provide a novel fluorescent protein in which on and off of fluorescence thereof can be controlled by irradiation with lights of two different wavelengths. The present invention provides a fluorescent protein shown in the following (a) or (b);(a) a protein which has the amino acid sequence shown in SEQ ID NO: 3 or 7; or (b) a protein which has an amino acid sequence comprising a deletion, substitution, and/or addition of one or several amino acids with respect to the amino acid sequence shown in SEQ ID NO: 3 or 7, and which has fluorescence characteristics of exhibiting a photochromic effect.

    摘要翻译： 本发明的目的是提供一种新的荧光蛋白，其中可以通过用两种不同波长的光照射来控制其荧光的开和关。 本发明提供下述（a）或（b）所示的荧光蛋白质。 （a）具有SEQ ID NO：3或7所示氨基酸序列的蛋白质; 或（b）相对于SEQ ID NO：3或7所示的氨基酸序列具有氨基酸序列的氨基酸序列的氨基酸序列的氨基酸序列的缺失，取代， 具有光致变色作用。

    OPTICAL SCANNER DEVICE
    6.
    发明申请
    OPTICAL SCANNER DEVICE 失效
    光学扫描仪器

    公开(公告)号：US20090101801A1

    公开(公告)日：2009-04-23

    申请号：US12340080

    申请日：2008-12-19

    申请人： Satoshi KARASAWA ,  Jun MIZUNO

    发明人： Satoshi KARASAWA ,  Jun MIZUNO

    IPC分类号： G01N21/84

    CPC分类号： G02B26/127 ,  G02B21/0048 ,  G02B26/101

    摘要： An optical scanner device, comprising a scanning unit, which casts irradiation light emitted from a light source in an arbitrary direction to scan an observation object, an objective lens system, which converges the irradiation light on the observation object, and a photo-detector unit, which is disposed on an optical axis of the objective lens system to have the irradiation light transmit therethrough, is provided. A position of the irradiation light converged on the observation object is detected based on a position of a light spot of the irradiation light transmitting through the photo-detector unit.

    摘要翻译： 一种光学扫描仪装置，包括扫描单元，其将从光源发射的照射光在任意方向上投射以扫描观察对象，将照射光会聚在观察对象上的物镜系统和光检测器单元 ，其设置在物镜系统的光轴上以使照射光透过。 基于通过光检测器单元透射的照射光的光点的位置来检测会聚在观察对象物上的照射光的位置。

    OPTICAL DEVICE
    7.
    发明申请
    OPTICAL DEVICE 审中-公开
    光学装置

    公开(公告)号：US20090052039A1

    公开(公告)日：2009-02-26

    申请号：US12192329

    申请日：2008-08-15

    申请人： Yuko YOKOYAMA ,  Masao TAKAHASHI ,  Satoshi KARASAWA

    发明人： Yuko YOKOYAMA ,  Masao TAKAHASHI ,  Satoshi KARASAWA

    IPC分类号： G02B5/18

    CPC分类号： G02B5/1866

    摘要： An optical device comprises a first optical system, a second optical system, a shading unit, and a diffraction grating. The first optical system transforms incident light to parallel light. The second optical system transforms incident light to parallel light. An optical axis of the second optical system is different from an optical axis of the first optical system. The shading unit has transmission areas having slit forms and shading areas having strip forms. The transmission areas and the shading areas are alternately arranged. The diffraction grating deflects the light transmitted by the transmission areas in a predetermined direction. Part of the incident light through the first optical system passes through the transmission areas, and the rest are shaded by the shading areas. Part of the incident light through the second optical system passes through the transmission areas, and the rest are shaded by the shading areas.

    摘要翻译： 光学装置包括第一光学系统，第二光学系统，遮蔽单元和衍射光栅。 第一光学系统将入射光转换成平行光。 第二光学系统将入射光转换为平行光。 第二光学系统的光轴与第一光学系统的光轴不同。 阴影单元具有具有狭缝形式的透射区域和具有条形的阴影区域。 传输区域和阴影区域交替布置。 衍射光栅使预定方向上的透射区域透射的光偏转。 通过第一光学系统的入射光的一部分通过透射区域，其余的被阴影区域遮蔽。 通过第二光学系统的入射光的一部分通过透射区域，其余的被遮蔽区域遮蔽。

    ENDOSCOPE WITH OPTICAL FIBER AND FIBER OPTICS SYSTEM
    8.
    发明申请
    ENDOSCOPE WITH OPTICAL FIBER AND FIBER OPTICS SYSTEM 失效
    内窥镜与光纤和光纤光学系统

    公开(公告)号：US20080161648A1

    公开(公告)日：2008-07-03

    申请号：US11619003

    申请日：2007-01-02

    申请人： Satoshi KARASAWA

    发明人： Satoshi KARASAWA

    IPC分类号： A61B1/07

    CPC分类号： A61B1/07 ,  A61B1/00096 ,  A61B1/0017 ,  A61B1/00172 ,  A61B5/0062 ,  Y10S385/902

    摘要： An endoscope has an optical fiber and at least one photo-detector. The optical fiber has a core that transmits illuminating light and at least one cladding that surrounds the core and transmits reflected light. The cladding has a refraction slope surface that is tapered toward a direction opposite the tip portion of the optical fiber. The photo-detector detects the reflected light that exits from the refraction slope surface by refraction.

    摘要翻译： 内窥镜具有光纤和至少一个光检测器。 光纤具有透射照明光的芯和围绕芯的至少一个包层并透射反射光。 包层具有朝向与光纤的前端部相反的方向逐渐变细的折射斜面。 光检测器通过折射检测从折射斜面出射的反射光。

    CONFOCAL OPTICAL SYSTEM
    9.
    发明申请
    CONFOCAL OPTICAL SYSTEM 有权
    协同光学系统

    公开(公告)号：US20100290100A1

    公开(公告)日：2010-11-18

    申请号：US12776525

    申请日：2010-05-10

    申请人： Satoshi KARASAWA

    发明人： Satoshi KARASAWA

    IPC分类号： G02B26/10

    CPC分类号： G02B26/103 ,  A61B1/00009 ,  A61B1/00172 ,  A61B1/043 ,  A61B1/063 ,  A61B5/0068 ,  A61B5/0084 ,  G02B6/262 ,  G02B23/243

    摘要： A confocal optical system comprising a scanning fiber is provided. The scanning fiber is a single-mode fiber of which a first end is shaped as a curved surface. The scanning fiber transmits illumination light to the first end. The illumination light is emitted toward an observation area. The illumination light emanates from the first end. The illumination light emanates from the first end striking a target area within the observation area. The first end receives at least one of reflected light and fluorescence from the target area. The reflected light is the illumination light reflected from the target area. The fluorescence is induced at the target area by illumination from the illumination light.

    摘要翻译： 提供了包括扫描光纤的共焦光学系统。 扫描光纤是单模光纤，其第一端被成形为曲面。 扫描光纤将照明光传输到第一端。 照明光朝向观察区域射出。 照明光从第一端发出。 照明光从第一端射出观察区域内的目标区域。 第一端从目标区域接收反射光和荧光中的至少一种。 反射光是从目标区域反射的照明光。 通过照明光的照射在目标区域处诱导荧光。

    METHOD FOR FABRICATING OPTICAL FIBER
    10.
    发明申请
    METHOD FOR FABRICATING OPTICAL FIBER 审中-公开
    制造光纤的方法

    公开(公告)号：US20080004491A1

    公开(公告)日：2008-01-03

    申请号：US11427219

    申请日：2006-06-28

    申请人： Satoshi KARASAWA

    发明人： Satoshi KARASAWA

    IPC分类号： B29D11/00 ,  C03C15/00 ,  A61B1/00

    CPC分类号： B29D11/00663 ,  C03C25/68 ,  G02B6/241 ,  G02B6/25

    摘要： A method of fabricating an optical fiber includes placing a distal end of an optical fiber in an etch-proof fiber-holder such that a tip portion of the optical fiber is covered by the fiber-holder, and an etching portion of the optical fiber adjacent to the tip portion is not covered by the fiber-holder. The optical fiber is exposed to an etching solution to change a profile of the etching portion, and the distal end of the optical fiber is removed from the fiber-holder.

    摘要翻译： 制造光纤的方法包括将光纤的远端放置在耐蚀刻光纤保持器中，使得光纤的末端部分被光纤保持器覆盖，并且光纤的蚀刻部分相邻 至顶端部分未被纤维架覆盖。 将光纤暴露于蚀刻溶液以改变蚀刻部分的轮廓，并且将光纤的远端从光纤保持器移除。