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    PRO20044 polypeptides
    5.
    发明授权
    PRO20044 polypeptides 有权
    PRO20044多肽

    公开(公告)号：US07250495B2

    公开(公告)日：2007-07-31

    申请号：US10223090

    申请日：2002-08-16

    申请人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

    发明人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

    IPC分类号： A61K38/00 ,  A61K38/17 ,  C07K14/00

    CPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02

    摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    摘要翻译： 公开了用于刺激或抑制哺乳动物，包括人类的血管发生和/或心血管化的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。 此外，本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

    PRO9821 nucleic acids
    6.
    发明授权
    PRO9821 nucleic acids 有权
    PRO9821核酸

    公开(公告)号：US07115415B2

    公开(公告)日：2006-10-03

    申请号：US10223081

    申请日：2002-08-16

    申请人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

    发明人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

    IPC分类号： C12N1/21 ,  C12N1/15 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63

    CPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02 ,  Y02A50/473

    摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    摘要翻译： 公开了用于刺激或抑制哺乳动物，包括人类的血管发生和/或心血管化的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。 此外，本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

    Anti-PRO9821 antibodies
    8.
    发明授权
    Anti-PRO9821 antibodies 有权
    抗PRO9821抗体

    公开(公告)号：US07265210B2

    公开(公告)日：2007-09-04

    申请号：US10223088

    申请日：2002-08-16

    申请人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

    发明人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

    IPC分类号： C07K16/00

    CPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02 ,  Y02A50/473

    摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    摘要翻译： 公开了用于刺激或抑制哺乳动物，包括人类的血管发生和/或心血管化的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。 此外，本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

    Pro9821 polypeptides
    9.
    发明授权
    Pro9821 polypeptides 有权
    Pro9821多肽

    公开(公告)号：US07164009B2

    公开(公告)日：2007-01-16

    申请号：US10223084

    申请日：2002-08-16

    申请人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

    发明人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

    IPC分类号： A61K38/00 ,  A61K38/17 ,  C07K14/00

    CPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02 ,  Y02A50/473

    摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    摘要翻译： 公开了用于刺激或抑制哺乳动物，包括人类的血管发生和/或心血管化的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。 此外，本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

    Anti-PR020044 antibodies
    10.
    发明授权
    Anti-PR020044 antibodies 有权
    抗PR020044抗体

    公开(公告)号：US07164007B2

    公开(公告)日：2007-01-16

    申请号：US10223082

    申请日：2002-08-16

    申请人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

    发明人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

    IPC分类号： C01K16/00

    CPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02

    摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    摘要翻译： 公开了用于刺激或抑制哺乳动物，包括人类的血管发生和/或心血管化的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。 此外，本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。