公开(公告)号：US20140368793A1

公开(公告)日：2014-12-18

申请号：US14335372

申请日：2014-07-18

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  David Muller ,  Amit Paranjape

IPC: A61B3/00 ,  G01J3/44 ,  A61B3/15 ,  G02B27/00 ,  A61B3/10 ,  A61B3/14

CPC classification number: A61B3/0025 ,  A61B3/10 ,  A61B3/1025 ,  A61B3/107 ,  A61B3/14 ,  A61B3/152 ,  A61B5/0075 ,  G01J3/4412 ,  G02B27/0093

Abstract: A system for determining biomechanical properties of corneal tissue includes a light source configured to provide an incident light and a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of corneal tissue. The incident light is reflected by the corneal tissue as scattered light. The system also includes a filter or attenuating device configured to block or attenuate the Rayleigh peak frequency of the scattered light, a spectrometer configured to receive the scattered light and process frequency characteristics of the received scattered light to determine a Brillouin frequency shift in response to the Rayleigh peak frequency being blocked or attenuated by the filter or attenuating device, and a processor configured to determine a three-dimensional profile of the corneal tissue according to the determined Brillouin frequency shift. The three-dimensional profile provides an indicator of one or more biomechanical properties of the corneal tissue.

Abstract translation: 用于确定角膜组织的生物力学性质的系统包括被配置为提供入射光的光源和被配置为扫描穿过角膜组织的多个横截面的入射光的共焦显微镜系统。 入射光被角膜组织反射为散射光。 该系统还包括被配置为阻挡或衰减散射光的瑞利峰值频率的滤波器或衰减装置，被配置为接收散射光的光谱仪和接收的散射光的处理频率特性，以响应于所述散射光的布里渊频移来确定布里渊频移 瑞利峰值频率被滤波器或衰减装置阻挡或衰减，以及处理器，被配置为根据确定的布里渊频移来确定角膜组织的三维轮廓。 三维轮廓提供角膜组织的一种或多种生物力学性质的指标。

公开(公告)号：US20140368792A1

公开(公告)日：2014-12-18

申请号：US14308678

申请日：2014-06-18

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  David Muller ,  Amit Paranjape

IPC: A61B3/107 ,  A61B3/14 ,  A61B3/113 ,  A61B3/10

CPC classification number: A61B3/107 ,  A61B3/10 ,  A61B3/1025 ,  A61B3/113 ,  A61B3/14 ,  A61B5/0075 ,  G01J3/0213 ,  G01J3/0237 ,  G01J3/2823 ,  G01J3/4412

Abstract: A system for determining biomechanical properties of corneal tissue includes a light source configured to provide an incident light and a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of corneal tissue. The incident light is reflected by the corneal tissue as scattered light. The system also includes a filter or attenuating device configured to block or attenuate the Rayleigh peak frequency of the scattered light, a spectrometer configured to receive the scattered light and process frequency characteristics of the received scattered light to determine a Brillouin frequency shift in response to the Rayleigh peak frequency being blocked or attenuated by the filter or attenuating device, and a processor configured to generate a three-dimensional profile of the corneal tissue according to the determined Brillouin frequency shift. The three-dimensional profile provides an indicator of one or more biomechanical properties of the corneal tissue.

Abstract translation: 用于确定角膜组织的生物力学性质的系统包括被配置为提供入射光的光源和被配置为扫描穿过角膜组织的多个横截面的入射光的共焦显微镜系统。 入射光被角膜组织反射为散射光。 该系统还包括被配置为阻挡或衰减散射光的瑞利峰值频率的滤波器或衰减装置，被配置为接收散射光的光谱仪和接收的散射光的处理频率特性，以响应于所述散射光的布里渊频移来确定布里渊频移 瑞利峰值频率被滤波器或衰减装置阻挡或衰减，以及处理器，被配置为根据确定的布里渊频移产生角膜组织的三维轮廓。 三维轮廓提供角膜组织的一种或多种生物力学性质的指标。

公开(公告)号：US09498114B2

公开(公告)日：2016-11-22

申请号：US14335372

申请日：2014-07-18

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  David Muller ,  Amit Paranjape

IPC: A61B3/14 ,  A61B3/00 ,  A61B3/10 ,  G02B27/00 ,  G01J3/44 ,  A61B3/107 ,  A61B3/15 ,  A61B5/00

CPC classification number: A61B3/0025 ,  A61B3/10 ,  A61B3/1025 ,  A61B3/107 ,  A61B3/14 ,  A61B3/152 ,  A61B5/0075 ,  G01J3/4412 ,  G02B27/0093

Abstract: A system for determining biomechanical properties of corneal tissue includes a light source configured to provide an incident light and a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of corneal tissue. The incident light is reflected by the corneal tissue as scattered light. The system also includes a filter or attenuating device configured to block or attenuate the Rayleigh peak frequency of the scattered light, a spectrometer configured to receive the scattered light and process frequency characteristics of the received scattered light to determine a Brillouin frequency shift in response to the Rayleigh peak frequency being blocked or attenuated by the filter or attenuating device, and a processor configured to determine a three-dimensional profile of the corneal tissue according to the determined Brillouin frequency shift. The three-dimensional profile provides an indicator of one or more biomechanical properties of the corneal tissue.

Abstract translation: 用于确定角膜组织的生物力学性质的系统包括被配置为提供入射光的光源和被配置为扫描穿过角膜组织的多个横截面的入射光的共焦显微镜系统。 入射光被角膜组织反射为散射光。 该系统还包括被配置为阻挡或衰减散射光的瑞利峰值频率的滤波器或衰减装置，被配置为接收散射光的光谱仪和接收的散射光的处理频率特性，以响应于所述散射光的布里渊频移来确定布里渊频移 瑞利峰值频率被滤波器或衰减装置阻挡或衰减，以及处理器，被配置为根据确定的布里渊频移来确定角膜组织的三维轮廓。 三维轮廓提供角膜组织的一种或多种生物力学性质的指标。

公开(公告)号：US09498122B2

公开(公告)日：2016-11-22

申请号：US14308678

申请日：2014-06-18

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  David Muller ,  Amit Paranjape

IPC: A61B3/107 ,  A61B3/14 ,  A61B3/113 ,  A61B3/10 ,  A61B5/00

CPC classification number: A61B3/107 ,  A61B3/10 ,  A61B3/1025 ,  A61B3/113 ,  A61B3/14 ,  A61B5/0075 ,  G01J3/0213 ,  G01J3/0237 ,  G01J3/2823 ,  G01J3/4412

Abstract: A system for determining biomechanical properties of corneal tissue includes a light source configured to provide an incident light and a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of corneal tissue. The incident light is reflected by the corneal tissue as scattered light. The system also includes a filter or attenuating device configured to block or attenuate the Rayleigh peak frequency of the scattered light, a spectrometer configured to receive the scattered light and process frequency characteristics of the received scattered light to determine a Brillouin frequency shift in response to the Rayleigh peak frequency being blocked or attenuated by the filter or attenuating device, and a processor configured to generate a three-dimensional profile of the corneal tissue according to the determined Brillouin frequency shift. The three-dimensional profile provides an indicator of one or more biomechanical properties of the corneal tissue.

Abstract translation: 用于确定角膜组织的生物力学性质的系统包括被配置为提供入射光的光源和被配置为扫描穿过角膜组织的多个横截面的入射光的共焦显微镜系统。 入射光被角膜组织反射为散射光。 该系统还包括被配置为阻挡或衰减散射光的瑞利峰值频率的滤波器或衰减装置，被配置为接收散射光的光谱仪和接收的散射光的处理频率特性，以响应于所述散射光的布里渊频移来确定布里渊频移 瑞利峰值频率被滤波器或衰减装置阻挡或衰减，以及处理器，被配置为根据确定的布里渊频移产生角膜组织的三维轮廓。 三维轮廓提供角膜组织的一种或多种生物力学性质的指标。