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公开(公告)号：US20220324984A1
公开(公告)日：2022-10-13
申请号：US17308888
申请日：2021-05-05
发明人： Andrew John GEALL , Venkata Ramana DOPPALAPUDI , David Sai-Ho CHU , Michael Caramian COCHRAN , Rachel Elizabeth JOHNS , Palani BALU , Rob BURKE , Beatrice Diana DARIMONT
IPC分类号： C07K16/28 , A61K31/713 , A61P35/02 , A61K47/68 , C12N15/113 , C07K16/30 , A61K31/7088 , A61K48/00 , A61P35/00 , C12N15/88 , A61K47/60
摘要： Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
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公开(公告)号：US20220096647A1
公开(公告)日：2022-03-31
申请号：US17499800
申请日：2021-10-12
发明人： Andrew John GEALL , Venkata Ramana DOPPALAPUDI , David Sai-Ho CHU , Michael Caramian COCHRAN , Michael HOOD , Beatrice Diana DARIMONT , Rob BURKE , Yunyu SHI , Gulin Erdogan MARELIUS , Barbora MALECOVA
IPC分类号： A61K47/68 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K39/395
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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公开(公告)号：US20230234978A1
公开(公告)日：2023-07-27
申请号：US18067975
申请日：2022-12-19
发明人： Venkata Ramana DOPPALAPUDI , Michael Caramian COCHRAN , David Sai-Ho CHU , Joel Daniel ARIAS , Rob BURKE
IPC分类号： C07F9/40 , C12N15/113 , C07F9/6558 , C07F9/6512
CPC分类号： C07F9/4006 , C12N15/113 , C07F9/65583 , C07F9/6512 , C12N2310/14 , C12N2310/351 , C12N2310/3513
摘要： Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
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公开(公告)号：US20230047754A1
公开(公告)日：2023-02-16
申请号：US17822342
申请日：2022-08-25
发明人： Andrew John GEALL , Venkata DOPPALAPUDI , David Sai-Ho CHU , Michael Caramian COCHRAN , Michael HOOD , Beatrice Diana DARIMONT , Rob BURKE , Yunyu SHI , Gulin Erdogan MARELIUS , Barbora MALECOVA
IPC分类号： A61K47/68 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K39/395
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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公开(公告)号：US20230201363A1
公开(公告)日：2023-06-29
申请号：US18056664
申请日：2022-11-17
发明人： Andrew John GEALL , Venkata DOPPALAPUDI , David Sai-Ho CHU , Michael Caramian COCHRAN , Michael HOOD , Beatrice Diana DARIMONT , Rob BURKE , Yunyu SHI , Gulin Erdogan MARELIUS , Barbora MALECOVA
IPC分类号： A61K47/68 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K39/395
CPC分类号： A61K47/6807 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K47/6849 , A61K39/395 , C12N2310/317 , C12N2310/3513 , C12N2310/14 , C12N2320/32 , A61K9/5107
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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公开(公告)号：US20220062434A1
公开(公告)日：2022-03-03
申请号：US17529197
申请日：2021-11-17
发明人： Andrew John GEALL , Venkata Ramana DOPPALAPUDI , David Sai-Ho CHU , Michael Caramian COCHRAN , Michael HOOD , Beatrice Diana DARIMONT , Rob BURKE , Yunyu SHI , Gulin Erdogan MARELIUS , Barbora MALECOVA
IPC分类号： A61K47/68 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K39/395
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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公开(公告)号：US20210095283A1
公开(公告)日：2021-04-01
申请号：US16960543
申请日：2019-01-03
发明人： Andrew John GEALL , Venkata Ramana DOPPALAPUDI , Rachel Elizabeth JOHNS , Rob BURKE , David Sai-Ho CHU , Michael Caramian COCHRAN , Michael David HOOD , Hanhua HUANG
IPC分类号： C12N15/113 , C07K16/28
摘要： Disclosed herein are heteroduplex nucleic acid molecules, heteroduplex nucleic acid conjugates, and pharmaceutical compositions for modulating a protein expression. Also described herein include methods of treating a disease or indication which utilize a heteroduplex nucleic acid molecule, a heteroduplex nucleic acid conjugate, or a pharmaceutical composition that comprises a heteroduplex nucleic acid molecule.
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公开(公告)号：US20230201362A1
公开(公告)日：2023-06-29
申请号：US17935922
申请日：2022-09-27
发明人： Andrew John GEALL , Venkata DOPPALAPUDI , David Sai-Ho CHU , Michael Caramian COCHRAN , Michael HOOD , Beatrice Diana DARIMONT , Rob BURKE , Yunyu SHI , Gulin Erdogan MARELIUS , Barbora MALECOVA
IPC分类号： A61K47/68 , A61P21/00 , C12N15/113 , C07K16/18 , A61K31/713 , A61K39/395 , A61K31/712
CPC分类号： A61K47/6807 , A61K31/712 , A61K31/713 , A61K39/395 , A61K47/6849 , A61P21/00 , C07K16/18 , C12N15/113 , A61K9/5107 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/3515 , C12N2320/31 , C12N2320/32
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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公开(公告)号：US20220395580A1
公开(公告)日：2022-12-15
申请号：US17364765
申请日：2021-06-30
发明人： Andrew John GEALL , Venkata Ramana DOPPALAPUDI , Joel Daniel ARIAS , David Sai-Ho CHU , Michael Caramian COCHRAN , Rob BURKE , Philip KOVACH , Barbora MALECOVA
IPC分类号： A61K47/68 , C07K16/28 , C12N15/113 , C07H17/00 , A61K47/64 , A61K31/713 , A61P35/00 , A61K47/60
摘要： Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
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公开(公告)号：US20220133900A1
公开(公告)日：2022-05-05
申请号：US17529207
申请日：2021-11-17
发明人： Andrew John GEALL , Venkata Ramana DOPPALAPUDI , David Sai-Ho CHU , Michael Caramian COCHRAN , Michael HOOD , Beatrice Diana DARIMONT , Rob BURKE , Yunyu SHI , Gulin Erdogan MARELIUS , Barbora MALECOVA
IPC分类号： A61K47/68 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K39/395
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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