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公开(公告)号：US20230201362A1
公开(公告)日：2023-06-29
申请号：US17935922
申请日：2022-09-27
发明人： Andrew John GEALL , Venkata DOPPALAPUDI , David Sai-Ho CHU , Michael Caramian COCHRAN , Michael HOOD , Beatrice Diana DARIMONT , Rob BURKE , Yunyu SHI , Gulin Erdogan MARELIUS , Barbora MALECOVA
IPC分类号： A61K47/68 , A61P21/00 , C12N15/113 , C07K16/18 , A61K31/713 , A61K39/395 , A61K31/712
CPC分类号： A61K47/6807 , A61K31/712 , A61K31/713 , A61K39/395 , A61K47/6849 , A61P21/00 , C07K16/18 , C12N15/113 , A61K9/5107 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/3515 , C12N2320/31 , C12N2320/32
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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公开(公告)号：US09427411B2
公开(公告)日：2016-08-30
申请号：US14457605
申请日：2014-08-12
申请人： JoAnna M. Esty
发明人： JoAnna M. Esty
CPC分类号： A61K9/5107 , A61K9/0014 , A61K9/06 , A61K9/5192 , A61K33/38 , A61K33/40 , A61K47/02 , A61K2300/00
摘要： The present invention relates to an antimicrobial topical composition and process for making such composition. The composition comprises of ionic silver, silver nanoparticles, and oxygen, combined within a gel medium and applied topically. The composition optimizes the ionic silver and silver nanoparticle ratio providing for sufficient ionic silver to be delivered as an immediate antimicrobial agent, and sufficient nanoparticle silver to provide time release for conversion to silver ions for continuing antimicrobial effectiveness.
摘要翻译： 本发明涉及抗微生物外用组合物及其制备方法。 组合物由离子银，银纳米颗粒和氧组成，在凝胶介质中组合并局部施用。 该组合物优化离子银和银纳米颗粒比例，提供足够的离子银作为即时抗微生物剂递送，并且足够的纳米银具有时间释放以转化为银离子以保持抗微生物效力。
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3.发明申请CARBON ENCAPSULATED TRANSITION METAL OXIDE NANOCOMPOSITE, A METHOD FOR ITS PREPARATION AND ITS USE IN LI-ION BATTERIES 有权碳纳米管过渡金属氧化物纳米复合材料，其制备方法及其在锂离子电池中的应用公开(公告)号：US20140294981A1
公开(公告)日：2014-10-02
申请号：US14349074
申请日：2012-09-26
发明人： Maximilian Fichtner , Horst Hahn , Raju Prakash
CPC分类号： A61K9/5107 , A61K33/26 , A61K47/02 , B82Y30/00 , C01B13/18 , C01G49/08 , C01P2004/64 , C01P2004/84 , C01P2004/86 , C01P2006/10 , C01P2006/40 , C01P2006/42 , C09C1/24 , H01F1/01 , H01M4/131 , H01M4/366 , H01M4/48 , H01M4/587 , H01M4/623 , H01M4/625 , H01M10/0525 , Y02E60/122 , Y10T428/2991
摘要： A nanocomposite includes carbon-encapsulated transition metal oxide nanoparticles. The carbon-encapsulated transition metal oxide nanoparticles comprise a transition metal oxide core having a diameter of from 5 nm to 50 nm covered by a graphitic coating having a thickness of from 1 nm to 5 nm.
摘要翻译： 纳米复合材料包括碳封装的过渡金属氧化物纳米颗粒。 碳封装的过渡金属氧化物纳米颗粒包含由厚度为1nm至5nm的石墨涂层覆盖的直径为5nm至50nm的过渡金属氧化物芯。
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公开(公告)号：US20130236504A1
公开(公告)日：2013-09-12
申请号：US13784930
申请日：2013-03-05
发明人： Frank Alexis , Bruce Frankel
IPC分类号： A61K31/52 , A61K31/4188
CPC分类号： A61K31/52 , A61K9/5107 , A61K31/495 , A61K45/06 , A61K47/6929 , A61K2300/00
摘要： Disclosed are delivery systems that can be used for treating cancer. The delivery systems include a delivery vehicle in conjunction with a chemo-adjuvant. The chemo-adjuvant can enhance the efficacy of a therapeutic agent that can be delivered in conjunction with the delivery vehicle or can be delivered independently of the delivery vehicle.
摘要翻译： 公开了可用于治疗癌症的递送系统。 递送系统包括与化学辅助剂结合的递送载体。 化学佐剂可以增强可以与递送载体一起递送的治疗剂的功效，或者可以独立于递送载体递送。
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公开(公告)号：US11872287B2
公开(公告)日：2024-01-16
申请号：US17935922
申请日：2022-09-27
发明人： Andrew John Geall , Venkata Doppalapudi , David Sai-Ho Chu , Michael Caramian Cochran , Michael Hood , Beatrice Diana Darimont , Rob Burke , Yunyu Shi , Gulin Erdogan Marelius , Barbora Malecova
IPC分类号： C07H21/04 , A61K47/68 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K39/395 , A61K9/51
CPC分类号： A61K47/6807 , A61K31/712 , A61K31/713 , A61K39/395 , A61K47/6849 , A61P21/00 , C07K16/18 , C12N15/113 , A61K9/5107 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/3513 , C12N2310/3515 , C12N2320/31 , C12N2320/32
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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公开(公告)号：US11712478B2
公开(公告)日：2023-08-01
申请号：US17499796
申请日：2021-10-12
发明人： Andrew John Geall , Venkata Ramana Doppalapudi , David Sai-Ho Chu , Michael Caramian Cochran , Michael Hood , Beatrice Diana Darimont , Rob Burke , Yunyu Shi , Gulin Erdogan Marelius , Barbora Malecova
IPC分类号： C07H21/04 , A61K47/68 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K39/395 , A61K9/51
CPC分类号： A61K47/6807 , A61K31/712 , A61K31/713 , A61K39/395 , A61K47/6849 , A61P21/00 , C07K16/18 , C12N15/113 , A61K9/5107 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/3513 , C12N2310/3515 , C12N2320/31 , C12N2320/32
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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公开(公告)号：US09399015B2
公开(公告)日：2016-07-26
申请号：US14038323
申请日：2013-09-26
发明人： Michael W. Fountain
IPC分类号： A61K8/14 , A61K9/14 , A61K9/107 , A61K9/127 , A61K9/51 , A61K31/375 , A61K31/122 , A61K31/167 , A61K31/522 , A61K31/7048 , A61K31/714 , A61K8/55 , A61Q19/00
CPC分类号： A61K9/5123 , A61K8/14 , A61K8/42 , A61K8/4953 , A61K8/553 , A61K8/602 , A61K8/67 , A61K8/673 , A61K9/0014 , A61K9/0053 , A61K9/1075 , A61K9/127 , A61K9/1271 , A61K9/14 , A61K9/51 , A61K9/5107 , A61K31/122 , A61K31/167 , A61K31/375 , A61K31/522 , A61K31/7048 , A61K31/714 , A61K2800/10 , A61K2800/413 , A61K2800/92 , A61Q19/00 , Y10S977/773 , Y10S977/797 , Y10S977/906 , Y10S977/907
摘要： Nanolipidic Particles (NLPs) having average mean diameters of 1 nm to 20 nm are made from a precursor solution. NLPs can be loaded with a desired passenger molecule. Assemblies of these particles, called NLP assemblies, result in a vehicle population of a desired size. Single application or multifunction NLP assemblies are made from the loaded NLPs and range in size from about 30 nm to about 200 nm. A method of using preloaded NLPs to make larger carrier vehicles or a mixed population provides increased encapsulation efficiency. NLPs have application in the cosmetics, pharmaceutical, and food and beverage industries.
摘要翻译： 平均直径为1nm〜20nm的纳米脂质颗粒（NLP）由前体溶液制成。 NLP可以装载所需的乘客分子。 称为NLP组件的这些颗粒的组件导致具有所需尺寸的车辆总体。 单一应用或多功能NLP组件由加载的NLP制成，尺寸范围为约30nm至约200nm。 使用预加载的NLP来制造更大载体载体或混合群体的方法提供了提高的包封效率。 NLP适用于化妆品，制药和食品饮料行业。
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公开(公告)号：US20140023703A1
公开(公告)日：2014-01-23
申请号：US13979092
申请日：2012-01-09
申请人： María José Alonso Fernández , Dolores Torres Lopez , Gustavo Rivera Rodriguez , Felipe Andrés Oyarzún Ampuero , Giovanna Lollo , Teresa Gonzalo Lázaro , Marcos Garcia Fuentes
发明人： María José Alonso Fernández , Dolores Torres Lopez , Gustavo Rivera Rodriguez , Felipe Andrés Oyarzún Ampuero , Giovanna Lollo , Teresa Gonzalo Lázaro , Marcos Garcia Fuentes
IPC分类号： A61K9/51 , A61K31/337
CPC分类号： A61K9/5107 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K9/5192 , A61K31/337 , A61K31/713 , A61K45/06 , A61K47/26 , B82Y5/00 , Y10S977/773 , Y10S977/906
摘要： The invention relates to a system for administering active ingredients, including nanocapsules comprising an oil, a cationic surfactant and a polymer selected from the group consisting of polyglutamic acid (PGA), polyglutamic-polyethyleneglycol acid (PGA-PEG), hyaluronic acid (HA) and polyasparagine (PAsn) or a combination of same and, optionally, an active ingredient, with the condition that when the polymer includes polyglutamic acid or polyglutamic-polyethyleneglycol acid (PGA-PEG) the active ingredient is not a didemnin or a tamandarin. The invention also relates to methods for obtaining said nanocapsule system, the pharmaceutical compositions thereof and the use of same in medicine.
摘要翻译： 本发明涉及一种用于施用活性成分的系统，包括包含油，阳离子表面活性剂和选自聚谷氨酸（PGA），聚谷氨酸 - 聚乙二醇酸（PGA-PEG），透明质酸（HA））的聚合物的纳米胶囊， 和聚天冬酰胺（PAsn）或其组合，和任选的活性成分，条件是当聚合物包括聚谷氨酸或聚谷氨酸 - 聚乙二醇酸（PGA-PEG）时，活性成分不是丹麦素或泰那康定。 本发明还涉及获得所述纳米胶囊系统的方法，其药物组合物及其在药物中的用途。
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公开(公告)号：US08545874B2
公开(公告)日：2013-10-01
申请号：US12772838
申请日：2010-05-03
申请人： Michael W. Fountain
发明人： Michael W. Fountain
IPC分类号： A61K8/14 , A61K9/51 , A61K31/375 , A61Q19/00 , A61K8/55
CPC分类号： A61K9/5123 , A61K8/14 , A61K8/42 , A61K8/4953 , A61K8/553 , A61K8/602 , A61K8/67 , A61K8/673 , A61K9/0014 , A61K9/0053 , A61K9/1075 , A61K9/127 , A61K9/1271 , A61K9/14 , A61K9/51 , A61K9/5107 , A61K31/122 , A61K31/167 , A61K31/375 , A61K31/522 , A61K31/7048 , A61K31/714 , A61K2800/10 , A61K2800/413 , A61K2800/92 , A61Q19/00 , Y10S977/773 , Y10S977/797 , Y10S977/906 , Y10S977/907
摘要： Nanolipidic Particles (NLPs) having average mean diameters of 1 nm to 20 nm are made from a precursor solution. NLPs can be loaded with a desired passenger molecule. Assemblies of these particles, called NLP assemblies, result in a vehicle population of a desired size. Single application or multifunction NLP assemblies are made from the loaded NLPs and range in size from about 30 to about 200 nm. A method of using preloaded NLPs to make larger carrier vehicles or a mixed population provides increased encapsulation efficiency. NLPs have application in the cosmetics, pharmaceutical, and food and beverage industries.
摘要翻译： 平均直径为1nm〜20nm的纳米脂质颗粒（NLP）由前体溶液制成。 NLP可以装载所需的乘客分子。 称为NLP组件的这些颗粒的组件导致具有所需尺寸的车辆总体。 单一应用或多功能NLP组件由加载的NLP制成，尺寸范围为约30至约200nm。 使用预加载的NLP来制造更大载体载体或混合群体的方法提供了提高的包封效率。 NLP适用于化妆品，制药和食品饮料行业。
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公开(公告)号：US20230201363A1
公开(公告)日：2023-06-29
申请号：US18056664
申请日：2022-11-17
发明人： Andrew John GEALL , Venkata DOPPALAPUDI , David Sai-Ho CHU , Michael Caramian COCHRAN , Michael HOOD , Beatrice Diana DARIMONT , Rob BURKE , Yunyu SHI , Gulin Erdogan MARELIUS , Barbora MALECOVA
IPC分类号： A61K47/68 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K39/395
CPC分类号： A61K47/6807 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K47/6849 , A61K39/395 , C12N2310/317 , C12N2310/3513 , C12N2310/14 , C12N2320/32 , A61K9/5107
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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