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公开(公告)号：US08143451B2
公开(公告)日：2012-03-27
申请号：US11867222
申请日：2007-10-04
IPC分类号： C07C211/00
CPC分类号： C07C209/60 , C07C231/12 , C07C211/27 , C07C211/29 , C07C237/16 , C07C237/20
摘要： The present invention relates to a method for the preparation of tertiary carbinamine compounds from diastereoselective allylation and crotylation of N-unsubstituted imines derived from ketones.
摘要翻译： 本发明涉及一种从非对映选择性烯丙基化制备叔胺组合物的方法和由酮衍生的N-未取代的亚胺的脱蛋白。
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公开(公告)号：US20080139847A1
公开(公告)日：2008-06-12
申请号：US11867222
申请日：2007-10-04
IPC分类号： C07C209/00
CPC分类号： C07C209/60 , C07C231/12 , C07C211/27 , C07C211/29 , C07C237/16 , C07C237/20
摘要： The present invention relates to a method for the preparation of tertiary carbinamine compounds from diastereoselective allylation and crotylation of N-unsubstituted imines derived from ketones.
摘要翻译： 本发明涉及由非对映选择性烯丙基化和N-酮衍生自酮的N-未取代的亚胺的丁酰化制备叔胺组合物的方法。
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3.发明授权公开(公告)号：US08383859B2
公开(公告)日：2013-02-26
申请号：US12593782
申请日：2008-03-28
IPC分类号： C07C209/00
CPC分类号： C07C209/60 , C07C213/02 , C07C253/30 , C07C211/21 , C07C211/25 , C07C211/27 , C07C211/29 , C07C217/46 , C07C217/58 , C07C255/58
摘要： The present application relates to novel methods for the preparation of primary, secondary and tertiary carbinamine compounds, particularly the preparation of compounds of formulae I, IV and VI, from a carbonyl compound of formula II in the presence of ammonia or an ammonium equivalent of the formula NH4+X−, by way of allylation, crotylation, arylation, reductive amination and catalytic hydrogenation.
摘要翻译： 本申请涉及在氨或铵当量的存在下由式II的羰基化合物制备伯，仲和叔甲胺化合物的新方法，特别是式I，IV和VI化合物的制备 公式NH4 + X-，通过烯丙基化，Crotylation，芳基化，还原胺化和催化氢化。
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公开(公告)号：US20100298572A1
公开(公告)日：2010-11-25
申请号：US12593815
申请日：2008-03-28
IPC分类号： C07D213/38 , C07C209/24 , C07C209/88 , C07D209/14
CPC分类号： C07C209/60 , B01J31/2428 , B01J2531/822 , C07B53/00 , C07B2200/07 , C07C213/02 , C07C253/30 , C07C2601/14 , C07D209/14 , C07D213/38 , C07C211/21 , C07C211/25 , C07C211/27 , C07C211/29 , C07C211/30 , C07C217/46 , C07C211/58 , C07C255/58
摘要： The present application relates to novel methods for the preparation of secondary carbinamine compounds, particularly the preparation of secondary carbinamine compounds of the formula Ia, formula Ib or formula IV from aldehydes of the formula II and boronic acids of the formula III or formula V, in the presence of ammonia or an ammonia equivalent of the formula NH4+X−.
摘要翻译： 本申请涉及制备二仲胺化合物的新方法，特别是式II，式Ib或式IV的仲式仲胺化合物由式II醛和式III或式V的硼酸在 存在氨或氨当量的式NH4 + X-。
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公开(公告)号：US08350047B2
公开(公告)日：2013-01-08
申请号：US12593815
申请日：2008-03-28
IPC分类号： C07D213/02 , C07D209/04 , C07B57/00 , C07C211/03 , C07C209/00
CPC分类号： C07C209/60 , B01J31/2428 , B01J2531/822 , C07B53/00 , C07B2200/07 , C07C213/02 , C07C253/30 , C07C2601/14 , C07D209/14 , C07D213/38 , C07C211/21 , C07C211/25 , C07C211/27 , C07C211/29 , C07C211/30 , C07C217/46 , C07C211/58 , C07C255/58
摘要： The present application relates to novel methods for the preparation of secondary carbinamine compounds, particularly the preparation of secondary carbinamine compounds of the formula Ia, formula Ib or formula IV from aldehydes of the formula II and boronic acids of the formula III or formula V, in the presence of ammonia or an ammonia equivalent of the formula NH4+X−.
摘要翻译： 本申请涉及制备二仲胺化合物的新方法，特别是式II，式Ib或式IV的仲式仲胺化合物由式II醛和式III或式V的硼酸在 存在氨或氨当量的式NH4 + X-。
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6.发明申请公开(公告)号：US20100174090A1
公开(公告)日：2010-07-08
申请号：US12593782
申请日：2008-03-28
IPC分类号： C07D213/00 , C07C211/21 , C07C211/26 , C07C217/48 , C07C211/25 , C07C255/50 , C07D209/16 , C07D307/02 , C07D333/20 , C07D207/30 , C07D277/20 , C07C237/02
CPC分类号： C07C209/60 , C07C213/02 , C07C253/30 , C07C211/21 , C07C211/25 , C07C211/27 , C07C211/29 , C07C217/46 , C07C217/58 , C07C255/58
摘要： The present application relates to novel methods for the preparation of primary, secondary and tertiary carbinamine compounds, particularly the preparation of compounds of formulae I, IV and VI, from a carbonyl compound of formula II in the presence of ammonia or an ammonium equivalent of the formula NH4+X−, by way of allylation, crotylation, arylation, reductive amination and catalytic hydrogenation.
摘要翻译： 本申请涉及在氨或铵当量的存在下由式II的羰基化合物制备伯，仲和叔甲胺化合物的新方法，特别是式I，IV和VI化合物的制备 公式NH4 + X-，通过烯丙基化，Crotylation，芳基化，还原胺化和催化氢化。
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7.发明授权Chiral acyclic diaminocarbene ligands, precursors therefore and their use in organic synthesis reactions 失效因此手性非环状二胺碳配体，前体及其在有机合成反应中的用途公开(公告)号：US08759541B2
公开(公告)日：2014-06-24
申请号：US13003039
申请日：2009-07-07
IPC分类号： C07D207/09 , C07D403/04
CPC分类号： C07D207/09 , B01J31/2265 , B01J31/2295 , B01J2231/321 , B01J2231/323 , B01J2531/822 , C07B53/00 , C07D207/06 , C07D403/04
摘要： The current application relates to a metal catalyst of formula (I): M[ADC][X]n, wherein M is a metal, ADC is a chiral acyclic diaminocarbene ligand, and X is a neutral or anionic ligand. The ADC ligand is prepared from the corresponding chiral formamidium salt precursor. The metal catalyst is used for asymmetric organic synthesis reactions such as hydrosilations, hydrogenations, conjugate additions, and cross-couplings.
摘要翻译： 本申请涉及式（I）的金属催化剂：M [ADC] [X] n，其中M是金属，ADC是手性无环二胺碳配体，X是中性或阴离子配体。 ADC配体由相应的手性甲脒盐前体制备。 金属催化剂用于不对称有机合成反应，如氢化硅，氢化，共轭添加和交联。
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8.发明授权Methods of performing cycloadditions, reaction mixtures, and methods of performing asymmetric catalytic reactions 失效进行环加成反应的方法，反应混合物和进行不对称催化反应的方法公开(公告)号：US07230125B1
公开(公告)日：2007-06-12
申请号：US10629537
申请日：2003-07-28
IPC分类号： C07D315/00
CPC分类号： C07D311/96 , C07D309/18 , C07D309/28 , C07D309/32 , C07D317/20 , C07D491/10
摘要： Methods of performing cycloadditions are described that include (a) combining a first reactant and a second reactant in a hydrogen bonding solvent to form a reaction mixture; and (b) reacting the first reactant and the second reactant to form a cycloadduct. Methods of performing asymmetric catalytic reactions are also described that include (a) combining a first reactant, a second reactant, and a catalytic amount of a chiral hydrogen-bond donor in a solvent to form a reaction mixture; and (b) reacting the first reactant and the second reactant to form an enantiomeric excess of a reaction product. Reaction mixtures corresponding to these methods are also described.
摘要翻译： 描述了进行环加成的方法，其包括（a）在氢键合溶剂中组合第一反应物和第二反应物以形成反应混合物; 和（b）使第一反应物和第二反应物反应形成环加成物。 还描述了进行不对称催化反应的方法，其包括（a）将第一反应物，第二反应物和催化量的手性氢键供体在溶剂中组合以形成反应混合物; 和（b）使第一反应物和第二反应物反应以形成对映体过量的反应产物。 还描述了对应于这些方法的反应混合物。
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9.发明申请CHIRAL ACYCLIC DIAMINOCARBENE LIGANDS, PRECURSORS THEREFORE AND THEIR USE IN ORGANIC SYNTHESIS REACTIONS 失效CHIRAL ACYCLIC DIAMINOCARBENE LIGANDS，前身及其在有机合成反应中的使用公开(公告)号：US20110118475A1
公开(公告)日：2011-05-19
申请号：US13003039
申请日：2009-07-07
IPC分类号： C07D403/06 , C07C33/34
CPC分类号： C07D207/09 , B01J31/2265 , B01J31/2295 , B01J2231/321 , B01J2231/323 , B01J2531/822 , C07B53/00 , C07D207/06 , C07D403/04
摘要： The current application relates to a metal catalyst of formula (I): M[ADC][X]n, wherein M is a metal, ADC is a chiral acyclic diaminocarbene ligand, and X is a neutral or anionic ligand. The ADC ligand is prepared from the corresponding chiral formamidium salt precursor. The metal catalyst is used for asymmetric organic synthesis reactions such as hydrosilations, hydrogenations, conjugate additions, and cross-couplings.
摘要翻译： 本申请涉及式（I）的金属催化剂：M [ADC] [X] n，其中M是金属，ADC是手性无环二胺碳配体，X是中性或阴离子配体。 ADC配体由相应的手性甲脒盐前体制备。 金属催化剂用于不对称有机合成反应，如氢化硅，氢化，共轭添加和交联。
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10.发明授权Methods of performing cycloadditions, reaction mixtures, and methods of performing asymmetric catalytic reactions 有权进行环加成反应的方法，反应混合物和进行不对称催化反应的方法公开(公告)号：US08513442B2
公开(公告)日：2013-08-20
申请号：US11811610
申请日：2007-06-11
IPC分类号： C07D315/00 , C07C211/00
CPC分类号： C07D311/96 , C07D309/18 , C07D309/28 , C07D309/32 , C07D317/20 , C07D491/10
摘要： Methods of performing cycloadditions are described that include (a) combining a first reactant and a second reactant in a hydrogen bonding solvent to form a reaction mixture; and (b) reacting the first reactant and the second reactant to form a cycloadduct. Methods of performing asymmetric catalytic reactions are also described that include (a) combining a first reactant, a second reactant, and a catalytic amount of a chiral hydrogen-bond donor in a solvent to form a reaction mixture; and (b) reacting the first reactant and the second reactant to form an enantiomeric excess of a reaction product. Reaction mixtures corresponding to these methods are also described.
摘要翻译： 描述了进行环加成的方法，其包括（a）在氢键合溶剂中组合第一反应物和第二反应物以形成反应混合物; 和（b）使第一反应物和第二反应物反应形成环加成物。 还描述了进行不对称催化反应的方法，其包括（a）将第一反应物，第二反应物和催化量的手性氢键供体在溶剂中组合以形成反应混合物; 和（b）使第一反应物和第二反应物反应以形成对映体过量的反应产物。 还描述了对应于这些方法的反应混合物。
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