公开(公告)号：US5179105A

公开(公告)日：1993-01-12

申请号：US775571

申请日：1991-10-15

申请人： Azuma Igarashi ,  Sachiko Maeda ,  Yasuhiro Hirakawa ,  Katsuyoshi Sugisaki ,  Shinji Ozawa

发明人： Azuma Igarashi ,  Sachiko Maeda ,  Yasuhiro Hirakawa ,  Katsuyoshi Sugisaki ,  Shinji Ozawa

IPC分类号： C07C317/28 ,  C07D215/14

CPC分类号： C07C317/28 ,  C07D215/14

摘要： A phenoxyacetic acid compound represented by the general formula I: ##STR1## wherein X is one member selected from the class consisting of hydrogen atom, halogen atoms, lower alkyl groups, trifluoromethyl group, alkoxy groups, hydroxy group, and cyano group, R.sup.1 is one member selected from the class consisting of hydrogen atom, methyl group, and ethyl group, n is an integer in the range of from 0 to 2, and Y is ##STR2## wherein R.sup.2 is hydrogen atom or n-propyl group and m is an integer in the range of from 1 to 5, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US5360909A

公开(公告)日：1994-11-01

申请号：US35178

申请日：1993-03-22

申请人： Azuma Igarashi ,  Sachiko Maeda ,  Katuyoshi Sugizaki ,  Takashi Shizawa ,  Atsumi Tajima ,  Kenichi Abe ,  Shinji Ozawa

发明人： Azuma Igarashi ,  Sachiko Maeda ,  Katuyoshi Sugizaki ,  Takashi Shizawa ,  Atsumi Tajima ,  Kenichi Abe ,  Shinji Ozawa

IPC分类号： C07C311/17 ,  C07C311/18 ,  C07C335/20 ,  C07D215/14 ,  C07D471/04 ,  A61K31/47 ,  C07D

CPC分类号： C07D215/14 ,  C07C311/17 ,  C07C311/18 ,  C07C335/20

摘要： Disclosed are phenoxyacetic acid compounds of formula (I): ##STR1## where X is a hydrogen atom, a lower alkyl group or a halogen atom;R1 is a carboxyl group or a lower alkoxycarbonyl group;Y is an oxygen atom, ##STR2## n is an integer of from 0 to 5; Z is ##STR3## R2 is a hydrogen atom or a lower alkyl group; and m is 0 or 1.The compounds and their physiologically acceptable salts are used as thromboxane A2 antagonistic agents, leukotriene antagonistic agents and/or anti-allergic agents.

摘要翻译： 公开了式（I）的苯氧基乙酸化合物：其中X是氢原子，低级烷基或卤素原子; R1是羧基或低级烷氧基羰基; Y为氧原子，n为0〜5的整数， Z是一个氢原子或一个低级烷基; 并且m为0或1.化合物及其生理学上可接受的盐用作血栓素A2拮抗剂，白细胞三烯拮抗剂和/或抗过敏剂。