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1.发明申请公开(公告)号：US20180221186A1
公开(公告)日：2018-08-09
申请号：US15878319
申请日：2018-01-23
申请人： BAROnova, Inc.
IPC分类号： A61F5/00
CPC分类号： A61F5/0089 , A61F5/003 , A61F5/004 , A61F5/0079
摘要： The present invention relates to gastric obstruction device deployment systems and a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal occluding member connected to a distal occluding member by a tether. The proximal occluding member is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the gastric obstruction device may be arranged transluminally with the distal occluding member disposed in the duodenum and the proximal occluding member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve.
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公开(公告)号：US20170065446A1
公开(公告)日：2017-03-09
申请号：US15356188
申请日：2016-11-18
申请人： BAROnova, Inc.
CPC分类号： A61F5/0079 , A61B5/065 , A61B17/12022 , A61B17/1204 , A61B17/12099 , A61B17/12136 , A61B17/12159 , A61B17/12163 , A61B17/12172 , A61B17/1219 , A61B2017/00119 , A61B2017/00221 , A61B2017/22069 , A61M5/14276 , A61M5/1723 , A61M31/002
摘要： The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member includes an apron member surrounding a first occluding member, which is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device of the present invention is arranged transluminally, with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve. In certain embodiments, a reservoir may be included for releasing a substance of interest, for example for releasing insulin from a reservoir disposed in the distal member. Sensors, actuators, and data transmission devices may also be included.
摘要翻译： 本发明涉及一种用于间歇地阻塞诸如胃开口的身体开口的装置，并且包括通过系绳连接到远端构件的近端构件。 近端构件包括围绕第一闭塞构件的围裙构件，其可从细长且较窄的构造形成为收缩或扩展但更宽的构造。 当在胃中使用时，本发明的装置是平行布置的，其中远端构件设置在十二指肠中，并且近端构件设置在幽门瓣上，间歇地闭塞幽门瓣膜，并且通过所述胃内容物阻止或延迟胃液的流动 幽门阀 在某些实施方案中，可以包括储存器以释放感兴趣的物质，例如用于从设置在远端构件中的储存器释放胰岛素。 还可以包括传感器，致动器和数据传输装置。
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公开(公告)号：US20170246018A1
公开(公告)日：2017-08-31
申请号：US15590865
申请日：2017-05-09
申请人： BAROnova, Inc.
发明人： Daniel R. BURNETT
CPC分类号： A61F5/0079 , A61F5/003 , A61F5/0036 , A61F5/0089 , A61F2210/0014 , A61N1/0472 , A61N1/0507 , A61N1/0509 , A61N1/36007
摘要： An intragastric weight-loss device is disclosed. The device includes a proximal occlusion member comprising a spiral structure, a bridging member, and a distal occlusion member. The spiral structure can be configured to spiral into a bulbous shape when the proximal occlusion member is delivered into the stomach. The bridging member can extend from the proximal occlusion member. The distal occlusion member can be coupled to a distal end of the bridging member. The proximal occlusion member can be configured to intermittently obstruct a pyloric valve of a patient such that passage of food through the pyloric valve is slowed.
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公开(公告)号：US20210077286A1
公开(公告)日：2021-03-18
申请号：US17103537
申请日：2020-11-24
申请人： BAROnova, Inc.
IPC分类号： A61F5/00
摘要： The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device may be arranged transluminally with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve.
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5.发明申请公开(公告)号：US20140186287A1
公开(公告)日：2014-07-03
申请号：US14178568
申请日：2014-02-12
申请人： BAROnova, Inc.
IPC分类号： A61K38/38 , A61K38/16 , A61K31/7088 , A61K31/78 , A61K31/765 , A61K31/715
CPC分类号： A61K9/0065 , A61F5/003 , A61F5/0036 , A61K9/2022 , A61K9/2027 , A61K9/205 , A61K9/2063 , A61K9/2833 , A61K9/4866 , A61K31/7088 , A61K31/715 , A61K31/765 , A61K31/78 , A61K38/16 , A61K38/38 , A61K2800/546
摘要： Provided are ingestible polymeric formulations and oral dosage forms for the reduction of gastric volume in the treatment of overweight and obese patients. The formulation includes an acid-sensitive, gelatin coating over a dehydrated hydrophilic polymer. When ingested, the acid-sensitive coating is quickly dissolved by gastric secretions and the hydrophilic polymer is exposed to the aqueous environment of the gastric milieu. The polymer absorbs water and expands to the point that will not allow the polymer to pass beyond the pyloric valve, and the expanded polymer is therefore trapped in the stomach.
摘要翻译： 提供了用于在超重和肥胖患者的治疗中减少胃体积的可摄入聚合物制剂和口服剂型。 该制剂包含脱水亲水性聚合物上的酸敏感的明胶涂层。 当摄入时，酸敏感涂层通过胃分泌物快速溶解，并且亲水性聚合物暴露于胃环境的水性环境中。 聚合物吸收水并膨胀到不允许聚合物超过幽门阀的点，因此膨胀的聚合物被捕获在胃中。
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公开(公告)号：US20190091053A1
公开(公告)日：2019-03-28
申请号：US16157975
申请日：2018-10-11
申请人： BAROnova, Inc.
发明人： Daniel R. BURNETT , Hugh NARCISO , Paul PASPA , David WISER , Stephen L. MEADE
CPC分类号： A61F5/0079 , A61B5/065 , A61B17/12022 , A61B17/1204 , A61B17/12099 , A61B17/12136 , A61B17/12159 , A61B17/12163 , A61B17/12172 , A61B17/1219 , A61B2017/00119 , A61B2017/00221 , A61B2017/22069 , A61M5/14276 , A61M5/1723 , A61M31/002
摘要： The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member includes an apron member surrounding a first occluding member, which is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device of the present invention is arranged transluminally, with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve. In certain embodiments, a reservoir may be included for releasing a substance of interest, for example for releasing insulin from a reservoir disposed in the distal member. Sensors, actuators, and data transmission devices may also be included.
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公开(公告)号：US20180344500A1
公开(公告)日：2018-12-06
申请号：US16101034
申请日：2018-08-10
申请人： BAROnova, Inc.
IPC分类号： A61F5/00
CPC分类号： A61F5/0079 , A61F5/0089
摘要： The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device may be arranged transluminally with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve.
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公开(公告)号：US20150011969A1
公开(公告)日：2015-01-08
申请号：US14495371
申请日：2014-09-24
申请人： BAROnova, Inc.
发明人： Daniel R. BURNETT , Hugh NARCISO , Paul PASPA , David WISER , Stephen MEADE
CPC分类号： A61F5/0079 , A61B5/065 , A61B17/12022 , A61B17/1204 , A61B17/12099 , A61B17/12136 , A61B17/12159 , A61B17/12163 , A61B17/12172 , A61B17/1219 , A61B2017/00119 , A61B2017/00221 , A61B2017/22069 , A61M5/14276 , A61M5/1723 , A61M31/002
摘要： The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member includes an apron member surrounding a first occluding member, which is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device of the present invention is arranged transluminally, with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve. In certain embodiments, a reservoir may be included for releasing a substance of interest, for example for releasing insulin from a reservoir disposed in the distal member. Sensors, actuators, and data transmission devices may also be included.
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公开(公告)号：US20220023082A1
公开(公告)日：2022-01-27
申请号：US17397683
申请日：2021-08-09
申请人： BAROnova, Inc.
IPC分类号： A61F5/00
摘要： The present invention relates to gastric obstruction device deployment systems and a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal occluding member connected to a distal occluding member by a tether. The proximal occluding member is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the gastric obstruction device may be arranged transluminally with the distal occluding member disposed in the duodenum and the proximal occluding member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve.
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公开(公告)号：US20160206461A1
公开(公告)日：2016-07-21
申请号：US14849450
申请日：2015-09-09
申请人： BAROnova, Inc.
IPC分类号： A61F5/00
CPC分类号： A61F5/0079 , A61F5/0089
摘要： The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device may be arranged transluminally with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying, the flow of gastric contents through the pyloric valve.
摘要翻译： 本发明涉及一种用于间歇地阻塞诸如胃开口的身体开口的装置，并且包括通过系绳连接到远端构件的近端构件。 近端构件可从细长且较窄的构造形成为收缩或扩展但更宽的构型。 当在胃中使用时，装置可以平行地布置，其中远端构件设置在十二指肠中，并且近端构件抵靠幽门瓣设置，间歇地闭塞幽门瓣膜并阻止或延迟通过幽门阀的胃内容物流。
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