公开(公告)号：US20180200170A1

公开(公告)日：2018-07-19

申请号：US15327071

申请日：2015-07-24

Applicant: BASF SE

Inventor： Bernd HERZOG ,  Dieter KOCKOTT ,  Heike FLÖSSER-MÜLLER

IPC: A61K8/44 ,  A61Q17/04 ,  A61K8/49 ,  A61K8/35 ,  A61K8/29 ,  A61K8/37

CPC classification number: A61K8/445 ,  A61K8/29 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/415 ,  A61K8/4926 ,  A61K8/4946 ,  A61K8/496 ,  A61K8/4966 ,  A61Q17/04

Abstract: The present invention relates to a sunscreen formulation comprising at least one of the UV filters (A) selected from (a) triazine derivatives; (b) cinnamic acid derivatives; (c) bis-resorcinyl triazines; (f) benzimidazole derivatives; (is) 4-Methylbenzylidene Camphor; (h) benzoyl piperazine derivatives; (j) benzoxazole derivatives; (k) diarylbutadiene derivatives; (I) phenyl benzotriazole derivatives; (n) benzylidene malonates; (o3) TEA-Salicylate; (r) imidazoline derivatives; (u) inorganic UV filters selected from metal oxides; (v) naphthalates; and (w) merocyanine derivatives; and optionally comprising at least one of the UV filters (B) selected from (d) aminobenzophenone derivatives; (e) dibenzoylmethane derivatives; (g) β,β-Diphenylacrylate derivatives; (i5) camphor derivatives different from; (o3) salicylate derivatives different from; (p) anthranilate derivatives; and (s) benzalmalonate derivatives; wherein the ratio R of the effective irradiance for previtamin D3 formation Epvd to the effective irradiance for erythema formation Eer on the skin is at least 1.8, for increasing the transmittance of UV radiation on human skin for the production of cholecalciferol (previtamin D3) and simultaneously for the use in a method for protecting the human skin against UV radiation when exposed to the sun, which method comprises applying said sunscreen formulation to the skin.

公开(公告)号：US20170290756A1

公开(公告)日：2017-10-12

申请号：US15509668

申请日：2015-09-04

Applicant: BASF SE

Inventor： JULIE GRUMELARD ,  Thomas EHLIS ,  Heike FLÖSSER-MÜLLER

IPC: A61K8/49 ,  A61K8/37 ,  A61Q17/04

CPC classification number: A61K8/496 ,  A61K8/37 ,  A61K8/4966 ,  A61K2800/592 ,  A61Q17/04

Abstract: Disclosed is a cosmetic or pharmaceutical composition comprising a UV filter combination of (a) at least one benzotriazole derivative corresponding to the formula wherein R1 is hydrogen; C1-C5alkyl; C1-C5alkoxy; or halogen; R2 is hydrogen; C1-C20alkyl; C1-C5alkoxy; C1-C5alkoxycarbonyl; C5-C10cycloalkyl; C5-C10aryl; or C5-C10aralkyl; R3 is C1-C20alkyl; C5-C10cycloalkyl; C1-C20alkoxy; or C5-C10cycloalkoxy; and R4 is hydrogen; or C1-C5alkyl; (b) at least one UV filter selected from (b1) benzylidene malonate UV filters; (b2) micronized 5,6,5′,6′-tetraphenyl-3,3′-(1,4-Phenylene)bis(1,2,4-Triazine) corresponding to the formula (b3) Benzoic acid, 4,4′-[[6-[[3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1 disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester; and (b4) 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-methylphenyl ester; and optionally (c) at least one UV filter selected from (c1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (c2) Butyl Methoxydibenzoylmethane; (c3) Diethylhexyl Butamido Triazone; (c4) Ethylhexyl Triazone; (c5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (c6) Ethylhexyl Methoxycinnamate; (c7) Ethylhexyl Salicylate; (c8) Homosalate; (c9) Octocrylene; (c10) Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (c11) Phenylbenzimidazole Sulfonic Acid; (c12) Titanium Dioxide; (c13) Tris-Biphenyl Triazine; (c14) (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone; (c15) merocyanine derivatives; (c16) Bis(butylbenzoate) diaminotriazine aminopropylsiloxane; and (c17) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, encapsulated in a polymer matrix.