公开(公告)号：US20180235885A1

公开(公告)日：2018-08-23

申请号：US15753186

申请日：2016-08-17

Applicant: BASF SE

Inventor： Heiko Alexander Schiffter ,  Maximilian Angel ,  Karl Kolter ,  Felicitas Guth

IPC: A61K9/16 ,  A61K47/69 ,  A61K9/20 ,  C08L39/06 ,  C08L33/08

CPC classification number: A61K9/1635 ,  A61K9/2027 ,  A61K31/00 ,  A61K31/426 ,  A61K31/451 ,  A61K31/4515 ,  A61K31/495 ,  A61K47/6933 ,  C08F220/06 ,  C08F220/18 ,  C08F226/10 ,  C08L33/08 ,  C08L39/06 ,  C08L2203/02

Abstract: Water-soluble polymeric salts of medicaments sparingly soluble in water consisting of a cationogenic medicament which, in uncharged form or as hydrochloride, has a solubility of less than 0.1% (m/m) in water, artificial intestinal juice or gastric juice, and an anionogenic water-soluble polymer having a solubility in water of at least 5% (m/m) in the pH range of 1 to 13 and which is obtained by free-radically initiated polymerization of a monomer mixture of i) 70 to 90% by weight N-vinylpyrrolidone and ii) 10 to 30% by weight acrylic acid, wherein the sum total of i) and ii) corresponds to 100% by weight.

公开(公告)号：US20180228730A1

公开(公告)日：2018-08-16

申请号：US15751889

申请日：2016-08-17

Applicant: BASF SE

Inventor： Heiko Alexander Schiffter ,  Maximilian Angel ,  Karl Kolter ,  Felicitas Guth

IPC: A61K9/16 ,  A61K9/14 ,  A61K9/48 ,  A61K31/4515

Abstract: Use of a water-soluble polymer having a solubility in water of greater than 5% (m/m) in the pH range of 1 to 13 and which is obtained by free-radically initiated polymerization of a monomer mixture of i) 70 to 90% by weight N-vinylpyrrolidone and ii) 10 to 30% by weight acrylic acid, wherein the sum total of i) and ii) corresponds to 100% by weight, for the formulation of basic active ingredients sparingly soluble in water, wherein the active ingredients in uncharged form or as hydrochloride have a solubility of less than 0.1% (m/m) in water, artificial intestinal juice or gastric juice.