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1.发明申请Active-Ingredient-Containing Solid Dispersions Based on Diethylaminoethyl Methacrylate Copolymers 审中-公开基于甲基丙烯酸二乙基氨基乙酯共聚物的含活性成分的固体分散体公开(公告)号：US20130345320A1
公开(公告)日：2013-12-26
申请号：US13919092
申请日：2013-06-17
Applicant: BASF SE
Inventor： Karl Kolter , Maximilian Angel , Matthias Karl , Silke Gebert , Michael Klemens Müller
IPC: A61K47/32
CPC classification number: A61K47/32 , A61K9/146 , A61K9/1635
Abstract: Described are solid dispersions of hydrophobic active ingredients and cationic copolymers of N,N-diethylaminoethyl methacrylate and methyl methacrylate in a weight ratio of the monomers of from 35:65 to 55:45. Also described are the preparation and use of such solid dispersions for pharmaceutical dosage forms.
Abstract translation: 描述了单体重量比为35:65至55:45的疏水性活性成分和甲基丙烯酸N，N-二乙基氨基乙酯和甲基丙烯酸甲酯的阳离子共聚物的固体分散体。 还描述了用于药物剂型的这种固体分散体的制备和用途。
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2.发明申请Production Of Pharmaceutical Protective Coatings With Good Resistance In A Neutral Environment 审中-公开在中性环境中生产具有良好电阻的药用保护涂料公开(公告)号：US20130236505A1
公开(公告)日：2013-09-12
申请号：US13790101
申请日：2013-03-08
Applicant: BASF SE
Inventor： Karl Kolter , Silke Gebert , Michael Klemens Müller , Maximilian Angel
CPC classification number: A61K47/32 , A61K9/0002 , A61K9/282 , A61K9/2846 , A61K9/5015 , A61K9/5026 , A61K47/12
Abstract: Pharmaceutical coatings obtained from coating compositions based on film-forming copolymers of N,N-diethylaminoethyl methacrylate (DEAEMA) and methyl methacrylate (MMA) comprising a weight ratio of DEAEMA:MMA in the range of 35:65 to 55:45, where the copolymers are present partially neutralized with C3-C10-dicarboxylic acids.
Abstract translation: 由基于N，N-二乙基氨基乙基甲基丙烯酸酯（DEAEMA）和甲基丙烯酸甲酯（MMA）的成膜共聚物的涂料组合物获得的药物涂料，其重量比为DEAEMA:MMA，范围为35:65至55:45，其中 共聚物用C3-C10-二羧酸部分中和。
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3.发明授权公开(公告)号：US10668156B2
公开(公告)日：2020-06-02
申请号：US13919092
申请日：2013-06-17
Applicant: BASF SE
Inventor： Karl Kolter , Maximilian Angel , Matthias Karl , Silke Gebert , Michael Klemens Mueller
Abstract: Described are solid dispersions of hydrophobic active ingredients and cationic copolymers of N,N-diethylaminoethyl methacrylate and methyl methacrylate in a weight ratio of the monomers of from 35:65 to 55:45. Also described are the preparation and use of such solid dispersions for pharmaceutical dosage forms.
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4.发明授权公开(公告)号：US09732200B2
公开(公告)日：2017-08-15
申请号：US14444305
申请日：2014-07-28
Applicant: BASF SE
Inventor： Maximilian Angel , Karl Kolter , Hartwig Voβ
IPC: C08K3/20 , A61K9/20 , A61K9/28 , C08F2/22 , C08F220/14 , C08F220/34 , C09D133/14 , C09J133/14 , A61K9/16 , A61K9/50 , A61K47/32 , A23L33/10
CPC classification number: C08K3/20 , A23L33/10 , A23V2002/00 , A61K9/1635 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2846 , A61K9/2853 , A61K9/5026 , A61K47/32 , C08F2/22 , C08F220/14 , C08F220/34 , C09D133/14 , C09J133/14
Abstract: The present invention relates to a process for preparing an aqueous polymer dispersion by free-radical emulsion polymerization of a monomer mixture which comprises N,N-diethylaminoethyl methacrylate, to the polymer dispersion obtainable by this process, and to the use thereof.
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5.发明申请AQUEOUS POLYMER DISPERSION BASED ON N,N-DIETHYLAMINOETHYL METHACRYLATE, ITS PREPARATION AND USE 审中-公开基于N，N-二甲基氨基乙基甲基丙烯酸酯的水性聚合物分散体，其制备和使用公开(公告)号：US20140335182A1
公开(公告)日：2014-11-13
申请号：US14444305
申请日：2014-07-28
Applicant: BASF SE
Inventor： Maximilian Angel , Karl Kolter , Hartwig Voß
CPC classification number: C08K3/20 , A23L33/10 , A23V2002/00 , A61K9/1635 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2846 , A61K9/2853 , A61K9/5026 , A61K47/32 , C08F2/22 , C08F220/14 , C08F220/34 , C09D133/14 , C09J133/14
Abstract: The present invention relates to a process for preparing an aqueous polymer dispersion by free-radical emulsion polymerization of a monomer mixture which comprises N,N-diethylaminoethyl methacrylate, to the polymer dispersion obtainable by this process, and to the use thereof.
Abstract translation: 本发明涉及一种通过使含有甲基丙烯酸N，N-二乙基氨基乙酯的单体混合物通过该方法获得的聚合物分散体的自由基乳液聚合制备聚合物水分散体的方法及其用途。
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Patent Agency Ranking
公开(公告)号：US12016926B2
公开(公告)日：2024-06-25
申请号：US16772273
申请日：2018-12-07
Applicant: BASF SE
Inventor： Ferdinand Paul Brandl , Theo Smit , Felicitas Guth , Karl Kolter , Maximilian Angel , Frank Schmidt
IPC: A61K9/16 , A61K31/216 , A61K31/5377 , A61K31/58 , A61K31/635 , A61K47/32 , C08F220/06 , C08F220/18 , C08F226/10
CPC classification number: A61K47/32 , A61K9/1635 , A61K31/216 , A61K31/5377 , A61K31/58 , A61K31/635 , C08F220/06 , C08F220/1803 , C08F220/1804 , C08F220/1806 , C08F226/10 , C08F220/1803 , C08F220/06 , C08F226/10 , C08F220/1806 , C08F220/06 , C08F226/10 , C08F220/1804 , C08F220/06 , C08F220/301
Abstract: Terpolymer, wherein 20 to 35% by weight of the structural units are derived from acrylic acid, 45 to 60% by weight of the structural units from a hydrophobic methacrylate selected from a group consisting of isopropyl methacrylate, tert-butyl methacrylate and cyclohexyl methacrylate and 15 to 40% by weight of the structural units from a third olefinic monomer selected from the group consisting of N-vinyl lactam, hydroxy ethyl methacrylate and phenoxyethyl acrylate with the proviso that the total amount of structural units derived from the three monomer groups adds up to 100% by weight, and the use of the terpolymers as crystallization inhibitors in pharmaceutical dosage forms for inhibiting the recrystallization in an aqueous environment of a human or animal body of an active ingredient.
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公开(公告)号：US11723871B2
公开(公告)日：2023-08-15
申请号：US17052934
申请日：2019-05-15
Applicant: BASF SE
Inventor： Theo Smit , Matthias Karl , Felicitas Guth , Maximilian Angel , Karl Kolter , Frank Schmidt , Maximilian Blochberger-Claus
IPC: A61K9/20
CPC classification number: A61K9/2027 , A61K9/2031
Abstract: The use of powder-form, crosslinked, water-insoluble, low-swelling polyacrylates as disintegrants for solid pharmaceutical dosage forms.
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公开(公告)号：US20180235885A1
公开(公告)日：2018-08-23
申请号：US15753186
申请日：2016-08-17
Applicant: BASF SE
Inventor： Heiko Alexander Schiffter , Maximilian Angel , Karl Kolter , Felicitas Guth
CPC classification number: A61K9/1635 , A61K9/2027 , A61K31/00 , A61K31/426 , A61K31/451 , A61K31/4515 , A61K31/495 , A61K47/6933 , C08F220/06 , C08F220/18 , C08F226/10 , C08L33/08 , C08L39/06 , C08L2203/02
Abstract: Water-soluble polymeric salts of medicaments sparingly soluble in water consisting of a cationogenic medicament which, in uncharged form or as hydrochloride, has a solubility of less than 0.1% (m/m) in water, artificial intestinal juice or gastric juice, and an anionogenic water-soluble polymer having a solubility in water of at least 5% (m/m) in the pH range of 1 to 13 and which is obtained by free-radically initiated polymerization of a monomer mixture of i) 70 to 90% by weight N-vinylpyrrolidone and ii) 10 to 30% by weight acrylic acid, wherein the sum total of i) and ii) corresponds to 100% by weight.
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9.发明申请公开(公告)号：US20180228730A1
公开(公告)日：2018-08-16
申请号：US15751889
申请日：2016-08-17
Applicant: BASF SE
Inventor： Heiko Alexander Schiffter , Maximilian Angel , Karl Kolter , Felicitas Guth
IPC: A61K9/16 , A61K9/14 , A61K9/48 , A61K31/4515
Abstract: Use of a water-soluble polymer having a solubility in water of greater than 5% (m/m) in the pH range of 1 to 13 and which is obtained by free-radically initiated polymerization of a monomer mixture of i) 70 to 90% by weight N-vinylpyrrolidone and ii) 10 to 30% by weight acrylic acid, wherein the sum total of i) and ii) corresponds to 100% by weight, for the formulation of basic active ingredients sparingly soluble in water, wherein the active ingredients in uncharged form or as hydrochloride have a solubility of less than 0.1% (m/m) in water, artificial intestinal juice or gastric juice.
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公开(公告)号：US20210069112A1
公开(公告)日：2021-03-11
申请号：US16772273
申请日：2018-12-07
Applicant: BASF SE
Inventor： Ferdinand Paul Brandl , Theo Smit , Felicitas Guth , Karl Kolter , Maximilian Angel , Frank Schmidt
IPC: A61K9/16 , C08F220/18 , A61K47/32 , A61K31/635 , A61K31/58 , A61K31/216 , A61K31/5377
Abstract: Terpolymer, wherein 20 to 35% by weight of the structural units are derived from acrylic acid, 45 to 60% by weight of the structural units from a hydrophobic methacrylate selected from a group consisting of isopropyl methacrylate, tert-butyl methacrylate and cyclohexyl methacrylate and 15 to 40% by weight of the structural units from a third olefinic monomer selected from the group consisting of N-vinyl lactam, hydroxy ethyl methacrylate and phenoxyethyl acrylate with the proviso that the total amount of structural units derived from the three monomer groups adds up to 100% by weight, and the use of the terpolymers as crystallization inhibitors in pharmaceutical dosage forms for inhibiting the recrystallization in an aqueous environment of a human or animal body of an active ingredient.
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