公开(公告)号：US20170027835A1

公开(公告)日：2017-02-02

申请号：US15302796

申请日：2015-04-07

Applicant: BASF SE

Inventor： Thomas Ehlis ,  Julie Grumelard

IPC: A61K8/49 ,  A61K8/41 ,  A61K8/35 ,  A61Q17/04

CPC classification number: A61K8/4966 ,  A61K8/35 ,  A61K8/415 ,  A61K8/494 ,  A61K8/496 ,  A61K8/585 ,  A61K2800/5922 ,  A61Q17/04

Abstract: Disclosed are cosmetic or pharmaceutical composition comprising a UV filter combination of (a) an aqueous dispersion of 5,6,5′,6′-tetraphenyl-3,3′-(1,4-Phenylene)bis(1,2,4-Triazine) corresponding to the formula in particulate form; and (b) the UV filters selected from (b1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (b2) Butyl Methoxydibenzoylmethane; (b3) Diethylhexyl Butamido Triazone; (b4) Ethylhexyl Triazone; (b5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (b6) Ethyhexyl Methoxycinnamate; (b7) Ethylhexyl Salicylate; (b8) Homosalate; (b9) Octocrylene; (b10) Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (b11) Phenylbenzimidazole Sulfonic Acid; (b12) Titanium Dioxide; (b13) Tris-Biphenyl Triazine; and (b14) (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1- carbonyl}-phenyl)-(4- diethylami- no-2-hydroxy-phenyl)-methanone; (b15) BBDAPT; Benzoic acid, 4,4′-[[6-[[3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1 disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester; (b16) benzylidene malonates; and (b17) merocyanine derivatives; (b18) Bis(butylbenzoate) diaminotriazine aminopropylsiloxane; (b19) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine) encapsulated in a polymer matrix; (b20) 2-(2H-Benzotriazol-2-yl)-6-[(2-ethylhexyloxy)methyl]-4-methylphenol; and (b21) 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-methylphenyl ester.

Abstract translation: 本发明公开了包含（a）5,6,5'，6'-四苯基-3,3' - （1,4-亚苯基）双（1,2,4 - 三嗪）与颗粒形式的式（1）相对应; 和（b）选自（b1）双 - 乙基己氧基苯酚甲氧基苯基三嗪的UV滤光器; （b2）丁基甲氧基二苯甲酰甲烷; （b3）丁酰己二酸二乙基己酯; （b4）乙基己基三嗪酮; （b5）二乙基氨基羟基苯甲酰己基苯甲酸酯; （b6）甲氧基肉桂酸乙基己酯; （b7）水杨酸乙基己酯; （b8）均质酸; （b9） （b10）亚甲基双苯并三唑基四甲基丁基苯酚; （b11）苯基苯并咪唑磺酸; （b12）二氧化钛; （b13）三联苯三嗪; 和（b14）（2- {4- [2-（4-二乙基氨基-2-羟基 - 苯甲酰基） - 苯甲酰基] - 哌嗪-1-羰基} - 苯基） - （4-二乙基氨基-2-羟基 - 苯基） 甲酮 （b15）BBDAPT; 苯甲酸，4,4' - [[6 - [[3- [1,3,3,3-四甲基-1 - [（三甲基甲硅烷基）氧] -1-二硅氧烷基]丙基]氨基-1,3,5-三嗪 - 2,4-二基]二亚氨基]双 - ，二丁酯; （b16）亚苄基丙二酸酯; 和（b17）部花青衍生物; （b18）二（丁基苯甲酸酯）二氨基三嗪氨基丙基硅氧烷; （b19）二聚乙氧基苯氧基苯酚三嗪）包封在聚合物基质中; （b20）2-（2H-苯并三唑-2-基）-6 - [（2-乙基己氧基）甲基] -4-甲基苯酚; 和（b21）2-丙烯酸，3-（4-甲氧基苯基） - ，2-甲基苯基酯。

公开(公告)号：US20160158132A1

公开(公告)日：2016-06-09

申请号：US15042704

申请日：2016-02-12

Applicant: BASF SE

Inventor： Bernd Herzog ,  Julie Grumelard

IPC: A61K8/49 ,  A61K8/41 ,  A61K8/37 ,  A61Q17/04

CPC classification number: A61K8/494 ,  A61K8/36 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/411 ,  A61K8/496 ,  A61K8/4966 ,  A61K2800/52 ,  A61K2800/592 ,  A61Q17/04

Abstract: Disclosed is the Use of UV absorbers selected from (a1) diphenylacrylates; and (a2) hydroxyphenyl triazines of formula wherein R1 is —O—R5; —COOR6; or —CO—NHR7; R2 is —O—R8, —COOR9; or —CO—NHR10; R3 is —O—R11; —COOR12; or —CO—NHR13; R5, R6, R7, R8, R9, R10, R11, R12 and R13 independently from each other are C1-C18alkyl; R4 is hydrogen; or hydroxy; and x is 0; or 1; for stabilizing cosmetic compositions comprising an organic UV absorber selected from (b1) a benzophenone derivatives of formula wherein R14 and R15 independently from each other are; C1-C20alkyl; C2-C20alkenyl; C3-C10cycloalkyl; C3-C10cycloalkenyl; or R14 and R15 together with the linking nitrogen atom form a 5- or 6-membered heterocyclic ring; n1 is a number from 1 to 4; when n1=1, R16 is a saturated or unsaturated heterocyclic radical; hydroxy-C1-C5alkyl; cyclohexyl optionally substituted with one or more C1-C5alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C1-C5alkylcarboxy; when n1 is 2, R16 is an alkylene-, cycloalkylene alkenylene or phenylene radical which is optionally substituted by a carbonyl- or carboxy group; a radical of formula *-CH2—C≡C—CH2-* or R16 together with A forms a bivalent radical of the formula wherein n2 is a number from 1 to 3; when n1 is 3, R16 is an alkantriyl radical; when n1 is 4, R16 is an alkanetetrayl radical; A is —O—; or —N(R17)—; and R17 is hydrogen; C1-C5alkyl; or hydroxy-C1-C5alkyl; (b2) a benzotriazole derivative of formula wherein T1 is optionally phenyl-substituted C1-C12alkyl; and (b3) a triazine derivative of formula wherein A is a radical of formula R17 and R21 independently from each other are hydrogen; C1-C18alkyl; or C6-C12aryl; R18, R19 and R20 independently from each other are hydrogen; or a radical of formula wherein, in formula (4a), at least one of the radicals R18, R19 and R20 are a radical of formula (4c); R22, R23, R24, R25 and R26 independently from each other are hydrogen; hydroxy; halogen; C1-C18alkyl; C1-C18alkoxy; C6-C12aryl; biphenylyl; C6-C12aryloxy; C1-C18alkylthio; carboxy; —COOM; C1-C18-alkylcarboxyl; aminocarbonyl; or mono- or di-C1-C18alkylamino; C1-C10acylamino; —COOH; M is an alkali metal ion; x is 1 or 2; and y is a number from 2 to 10; and UV filters selected from (c1) cinnamic acid derivatives; and (c2) dibenzoylmethane derivatives.

公开(公告)号：US11793742B2

公开(公告)日：2023-10-24

申请号：US15302796

申请日：2015-04-07

Applicant: BASF SE

Inventor： Thomas Ehlis ,  Julie Grumelard

IPC: A61K8/49 ,  A61K8/35 ,  A61K8/41 ,  A61Q17/04 ,  A61K8/58

CPC classification number: A61K8/4966 ,  A61K8/35 ,  A61K8/415 ,  A61K8/494 ,  A61K8/496 ,  A61K8/585 ,  A61Q17/04 ,  A61K2800/5922

Abstract: Disclosed are cosmetic or pharmaceutical composition comprising a UV filter combination of

(a) an aqueous dispersion of 5,6,5′,6′-tetraphenyl-3,3′-(1,4-Phenylene)bis(1,2,4-Triazine) corresponding to the formula








in particulate form; and


(b) the UV filters selected from

(b1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine;
(b2) Butyl Methoxydibenzoylmethane;
(b3) Diethylhexyl Butamido Triazone;
(b4) Ethylhexyl Triazone;
(b5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate;
(b6) Ethyhexyl Methoxycinnamate;
(b7) Ethylhexyl Salicylate;
(b8) Homosalate;
(b9) Octocrylene;
(b10) Methylene Bis-Benzotriazolyl Tetramethylbutylphenol;
(b11) Phenylbenzimidazole Sulfonic Acid;
(b12) Titanium Dioxide;
(b13) Tris-Biphenyl Triazine; and
(b14) (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone;
(b15) BBDAPT; Benzoic acid, 4,4′-[[6-[[3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1 disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester;
(b16) benzylidene malonates; and
(b17) merocyanine derivatives;
(b18) Bis(butylbenzoate) diaminotriazine aminopropylsiloxane;
(b19) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine) encapsulated in a polymer matrix;
(b20) 2-(2H-Benzotriazol-2-yl)-6-[(2-ethylhexyloxy)methyl]-4-methylphenol; and
(b21) 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-methylphenyl ester.