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    Storage-Stable Dust-Free Homogeneous Particulate Formulation Comprising At Least One Water-Soluble Vitamin E-Derivative And At Least One Hydrophilic Polymer
    1.
    发明申请
    Storage-Stable Dust-Free Homogeneous Particulate Formulation Comprising At Least One Water-Soluble Vitamin E-Derivative And At Least One Hydrophilic Polymer 有权
    储存稳定的无尘均匀颗粒配方包含至少一种水溶性维生素E衍生物和至少一种亲水性聚合物

    公开(公告)号：US20140086993A1

    公开(公告)日：2014-03-27

    申请号：US14036445

    申请日：2013-09-25

    Applicant: BASF SE

    Inventor： Felicitas Guth ,  Karl Kolter ,  Michael Schönherr ,  Franz Weber

    IPC: A61K47/22 ,  A61K47/32

    CPC classification number: A61K47/22 ,  A61K47/32

    Abstract: A storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble Vitamin E-derivative and at least one hydrophilic polymer. In one embodiment the storage-stable dust-free homogeneous particle formulation, consists of (j) at least one water-soluble Vitamin E-derivative, (k) at least one hydrophilic polymer, (l) optionally additional surface-active substances, and (m) optionally additional pharmaceutical additives, with the proviso, that the sum of (a), (b), (c) and (d) equals 100% by weight of the formulation, and wherein the fines fraction with particle diameters of less than 100 μm is less than 10% by weight. Methods of making the particulate formulation by a spray granulation process are also provided.

    Abstract translation: 包含至少一种水溶性维生素E衍生物和至少一种亲水性聚合物的储存稳定的无尘均质颗粒制剂。 在一个实施方案中，储存稳定的无尘均质颗粒制剂由（j）至少一种水溶性维生素E衍生物，（k）至少一种亲水性聚合物，（l）任选地附加的表面活性物质组成，以及 （m）任选的另外的药物添加剂，条件是（a），（b），（c）和（d）的总和等于制剂的100重量％，并且其中粒径小于 小于100重量％。 还提供了通过喷雾造粒方法制备颗粒制剂的方法。

    Storage-Stable Dust-Free Homogeneous Particulate Formulation
    4.
    发明申请
    Storage-Stable Dust-Free Homogeneous Particulate Formulation 有权
    储存稳定的无尘均匀颗粒制剂

    公开(公告)号：US20140086992A1

    公开(公告)日：2014-03-27

    申请号：US14036365

    申请日：2013-09-25

    Applicant: BASF SE

    Inventor： Felicitas Guth ,  Karl Kolter ,  Michael Schönherr ,  Michael Klemens Müller

    IPC: A61K9/16

    CPC classification number: A61K9/1617 ,  A61K9/1682 ,  A61K47/22 ,  A61K47/32

    Abstract: Described is a storage-stable dust-free homogeneous particulate formulation. The formulation consists of (a) at least one water-soluble Vitamin E-derivative, (b) at least one hydrophilic polymer, (c) optionally additional surface-active substances, and (d) optionally additional pharmaceutical additives. The sum of (a), (b), (c) and (d) equals 100% by weight of the formulation. The fines fraction with particle diameters of less than 100 μm is less than 10% by weight. Describe also is a process for manufacturing the formulation, and use of the formulation as a solubilizing composition in pharmaceutical formulations.

    Abstract translation: 描述了储存稳定的无尘均匀颗粒制剂。 该制剂包含（a）至少一种水溶性维生素E衍生物，（b）至少一种亲水性聚合物，（c）任选地附加的表面活性物质，和（d）任选的另外的药物添加剂。 （a），（b），（c）和（d）的总和等于制剂重量的100％。 粒径小于100μm的细小部分小于10重量％。 还描述了制备制剂的方法，以及在药物制剂中使用该制剂作为增溶组合物。

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