Storage-Stable Dust-Free Homogeneous Particulate Formulation Comprising At Least One Water-Soluble Vitamin E-Derivative And At Least One Hydrophilic Polymer
    5.
    发明申请
    Storage-Stable Dust-Free Homogeneous Particulate Formulation Comprising At Least One Water-Soluble Vitamin E-Derivative And At Least One Hydrophilic Polymer 有权
    储存稳定的无尘均匀颗粒配方包含至少一种水溶性维生素E衍生物和至少一种亲水性聚合物

    公开(公告)号:US20140086993A1

    公开(公告)日:2014-03-27

    申请号:US14036445

    申请日:2013-09-25

    申请人: BASF SE

    IPC分类号: A61K47/22 A61K47/32

    CPC分类号: A61K47/22 A61K47/32

    摘要: A storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble Vitamin E-derivative and at least one hydrophilic polymer. In one embodiment the storage-stable dust-free homogeneous particle formulation, consists of (j) at least one water-soluble Vitamin E-derivative, (k) at least one hydrophilic polymer, (l) optionally additional surface-active substances, and (m) optionally additional pharmaceutical additives, with the proviso, that the sum of (a), (b), (c) and (d) equals 100% by weight of the formulation, and wherein the fines fraction with particle diameters of less than 100 μm is less than 10% by weight. Methods of making the particulate formulation by a spray granulation process are also provided.

    摘要翻译: 包含至少一种水溶性维生素E衍生物和至少一种亲水性聚合物的储存稳定的无尘均质颗粒制剂。 在一个实施方案中,储存稳定的无尘均质颗粒制剂由(j)至少一种水溶性维生素E衍生物,(k)至少一种亲水性聚合物,(l)任选地附加的表面活性物质组成,以及 (m)任选的另外的药物添加剂,条件是(a),(b),(c)和(d)的总和等于制剂的100重量%,并且其中粒径小于 小于100重量%。 还提供了通过喷雾造粒方法制备颗粒制剂的方法。